The Climate in the European Union and the Enlarged European Region is a Determinant of the COVID-19 Case Fatality Ratio

Orrù, Germano; Romano, Ferdinando; Scano, Alessandra; Restivo, Angelo; Giacco, Stefano Del; Deidda, Simona; Firinu, Davide; Campagna, Marcello; Cossu, Giulia; Chessa, Luchino; Kalcev, Goce; Carta, Mauro Giovanni

doi:10.33263/briac113.1097910986

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Thus, individuals with hyperthymic temperaments and personalities (explorers and novelty seekers) may be able to adjust to new situations [ 30 - 32 ]. On the other hand, we should not forget the fact that the prevalence of bipolar disorders has increased in urban areas in the last decades, where the severity of the disease directly relates to exposure to modern living conditions and the environment [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Is a Genetic Variant associated with Bipolar Disorder Frequent in People without Bipolar Disorder but with Characteristics of Hyperactivity and Novelty Seeking?

Kalcev¹,

Scano²,

Orrù³

et al. 2023

CPEMH

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Objective: The objective is to verify whether a genetic condition associated with bipolar disorder (BD) is frequent in old adults adapted to their environment, without BD, but with aptitudes for hyperactivity and novelty seeking (H/NS). Methods: In this cross-sectional study, the study sample included healthy elderly people (40 participants, aged 60 or older) living in an urban area and recruited from a previous study on physical exercise and active aging, who were compared with 21 old adults with BD from the same area. The genetic methodology consisted of blood sampling, DNA extraction, real-time PCR jointly with FRET probes, and the SANGER sequencing method. The genetic variant RS1006737 of CACNA1C, found to be associated with bipolar disorder diagnosis, was investigated. Results: The frequency of the RS1006737 genetic variant in the study group (H/NS) is not higher than in the BD group and is statistically significantly higher than in all the control groups found in the literature. However, the familiarity for BD is higher in old adults with BD than in the H/NS sample without BD. The risk of BD in the family (also considering those without BD but with family members with BD) is not associated with the presence of the genetic variant examined. Conclusion: The study suggests that the gene examined is associated with characteristics of hyperactivity rather than just BD. Nevertheless, choosing to participate in an exercise program is an excessively general way to identify H/NS. The next step would be to identify the old adults with well-defined H/NS features with an adequate tool.

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Section: Discussionmentioning

confidence: 99%

Is a Genetic Variant associated with Bipolar Disorder Frequent in People without Bipolar Disorder but with Characteristics of Hyperactivity and Novelty Seeking?

Kalcev¹,

Scano²,

Orrù³

et al. 2023

CPEMH

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“…Different hypotheses have been proposed to explain this inhomogeneous distribution of cases from a demographic, geographic, and genetic perspective (3)(4)(5). Although the Italian Government-mandated containment restriction extended to all national territories on March 11, on March 19, Italy overtook China in the number of deaths due to coronavirus disease 2019 (3,405) and was (temporarily) the country with the most deaths due to the disease.…”

Section: Introduction: Epidemic Chrono-history and The Evolution Of Tmentioning

confidence: 99%

COVID-19 and Italian Healthcare Workers From the Initial Sacrifice to the mRNA Vaccine: Pandemic Chrono-History, Epidemiological Data, Ethical Dilemmas, and Future Challenges

Nioi

Napoli

Lobina

et al. 2021

Front. Public Health

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On March 11, 2020, the World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19) outbreak a pandemic. Simultaneously, in Italy, in which the first case had occurred on February 18, the rigid phase of the lockdown began. The country has attracted worldwide attention, becoming at the same time a field of study both concerning the spread of the pandemic and advanced assessments of the effectiveness of political, public health, and therapeutic measures. The protagonists of the Italian crisis were the healthcare workers (HCWs) who were exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) without having any perception of what they were facing, courageously contributing to the containment of the epidemic to be defined by the media as “heroes.” However, in the first phase of the pandemic (March–May 2020), the price that the Italian Public Health System had to pay both in terms of the number of positive virus cases and deaths among the HCWs was beyond and represented a peculiarity compared to what happened in other countries. In the current study, after a summary of the evolution of the pandemic in Italy, we offer an analysis of the statistical data concerning contagions and deaths among healthcare workers (physicians in particular). In conclusion, we describe the critical issues that still need to be resolved and the future challenges facing healthcare workers and the general population.

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Differences in lethality and diffusion of Covid-19 in countries using different kinds of vaccines

Carta

Orrù

Peracchia

et al. 2022

Journal of Public Health Research

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To verify if lethality and diffusivity of Covid-19 correlated with percentage of people vaccinated in different countries and whether results on these indicators were comparable under different types of vaccines. A linear regression analysis was conducted between vaccines/inhabitant, new cases/inhabitants and ratio deaths/cases. A comparison between the three indicators was carried out in countries subdivided by kind of vaccine. The proportion of vaccinations/inhabitants correlates negatively with proportion of deaths × 100 cases ( R = −3.90, p < 0.0001), but didn’t on incidence of new cases. Countries with prevalence of mRNA vaccines were similar to others on incidence of new cases; but a lower lethality of Sars-Cov2 was found than in countries with prevalence of viral vehicle vaccines ( F = 6.064, p = 0.0174) but didn’t against countries with prevalence of inactivated vaccines. The higher is the proportion of vaccine/inhabitant in a given country, the less is the fraction of infected people who die.

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The Climate in the European Union and the Enlarged European Region is a Determinant of the COVID-19 Case Fatality Ratio

Cited by 5 publications

References 13 publications

Is a Genetic Variant associated with Bipolar Disorder Frequent in People without Bipolar Disorder but with Characteristics of Hyperactivity and Novelty Seeking?

Is a Genetic Variant associated with Bipolar Disorder Frequent in People without Bipolar Disorder but with Characteristics of Hyperactivity and Novelty Seeking?

COVID-19 and Italian Healthcare Workers From the Initial Sacrifice to the mRNA Vaccine: Pandemic Chrono-History, Epidemiological Data, Ethical Dilemmas, and Future Challenges

Differences in lethality and diffusion of Covid-19 in countries using different kinds of vaccines

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