The ClearPET/spl trade/ LSO/LuYAP phoswich scanner: a high performance small animal PET system

Ziemons, K.; Auffray, E.; Barbier, R.; Brandenburg, G.; Bruyndonckx, Peter; Choi, Yong; Christ, Daryl; Costes, Nicolas; Déclais, Y.; Devroede, O.; Dujardin, Christophe; Fedorov, A.; Heinrichs, U.; Hollendung, A.; Korjhik, M. J.; Krieguer, M.; Kuntner, Claudia; Largeron, G.; Lartizien, Carole; Larue, H.; Lecoq, P.; Léonard, Sarah; Martcau, J.; Morel, C.; Mosset, J.-B.; Parl, C.; Pédrini, C.; Petrosyan, A.; Pietrzyk, U.; Rey, M.; Saladino, S.; Sappey–Marinier, Dominique; Simon, L.; Streun, M.; Tavernier, S.; Vieira, J.-M.

doi:10.1109/nssmic.2003.1352212

Cited by 13 publications

(11 citation statements)

References 10 publications

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“…These requirements led to the development of new scintillation materials such as LSO or LYSO crystals [6,7], which are now widely used in preclinical systems because of their high and fast light output. Most of the commercial preclinical scanners are based on small individual scintillators coupled to photomultipliers such as the microPET R4 and P4 scanners [8,9], the microPET Focus family [10,11], the Inveon scanner [12], the nanoPET/CT scanner [13], the Triumph®II -PET/SPECT/CT system [14], the Super Argus PET/CT [15], the ClearPET scanner [16] or the Genisys4 system [17,18]. In contrast to these scanners, which are based on individual small scintillator pixels, the ALBIRA scanner is made of larger monolithic scintillators, where the point of interaction is estimated from the scintillation light spread into the position sensitive photomultiplier [19,20].…”

Section: Scanner Specific Factorsmentioning

confidence: 99%

Quantitative preclinical PET imaging: opportunities and challenges

Kuntner

Stout

2014

Front. Physics

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PET imaging of metabolism involves many choices, from hardware settings, software options to animal handling considerations. How to decide what settings or conditions to use is not straightforward, as the experimental design is dependent on the particular science being investigated. There is no single answer, yet there are factors that are common to all experiments that are the subject of this review. From physics to physiology, there are many factors to consider, each of which can have a significant impact upon measurements of metabolism in vivo. This review examines the most common factors related to all types of quantitative PET imaging.

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Section: Scanner Specific Factorsmentioning

confidence: 99%

Quantitative preclinical PET imaging: opportunities and challenges

Kuntner

Stout

2014

Front. Physics

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“…However most designs still rely on an external constant fraction discriminator (CFD) or similar circuit for the generation of the event time stamp. There are some exceptions to this last statement [4]- [7] that replace the external circuit by additional digital processing.…”

Section: Introductionmentioning

confidence: 99%

New embedded digital front-end for high resolution PET scanner

Guerra

Espinosa

Ortuño

et al. 2006

IEEE Trans. Nucl. Sci.

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Abstract--This work describes a new digital front-end for a high-resolution low-cost animal PET scanner which is currently under development. The advances in flexibility and size of modern FPGAs together with the release of new tools enable the integration of most of the front-end electronics in a single FPGA. The implemented system includes a small 32-bit RISC processor, several peripherals attached to the internal buses and a special DSP unit closely attached to the processor which is dedicated to the detection of the gamma events. On top of these, a small footprint real time operating system abstracts the underlying hardware, providing the mechanisms to combine on-chip slow control and data streaming.Index Terms-Digital front-end electronics, high resolution positron emission tomography, real time system architectures.

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“…The intrinsic measurements are done with a ClearPET prototype [7] and have shown a spatial resolution with a mean of 1.48mm FWHM and a typical energy resolution of (24,3±0.4)% for the LuYAP layer and (23,2±0.3)% for the LSO layer. First tomographic measurements with the ClearPET Neuro scanner are performed with a full-equipped gantry.…”

Section: First Results and Discussionmentioning

confidence: 99%

“…A detector cassette was designed by arranging a set of four multi-channel PMTs (R7600M64, Hamamatsu) in-line including the corresponding front-end electronic: analog and decoder boards in front, one FPGA board, one slow control and finally an opto link transmitter board to send the data from the gantry to the first preprocessing PCs (see figure 1). For the multi-ring ClearPET versions [7] …”

Section: Clearpet Detector Modulesmentioning

confidence: 99%

The ClearPET. Neuro scanner: A dedicated LSO/LuYAP phoswich small animal PET scanner

Ziemons

Achten²,

Auffray³

et al.

IEEE Symposium Conference Record Nuclear Science 2004.

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The ClearPET initiative is a project being undertaken by working groups of the Crystal Clear Collaboration (CCC). Its aim is to develop a second-generation high performance small animal positron emission tomograph. The ClearPET camera is expected to provide both high sensitivity and high spatial resolution. It uses a phoswich arranging combining two types of lutetium-based scintillator materials: LSO and LuYAP:Ce. Based on the same detector modules different designs from each collaboration partner are realized for their associated medical institutes. Each dedicated version is expressed by the name ClearPET plus an extension.The ClearPET Neuro scanner is a dedicated small animal scanner to allow measurements of signal transduction in nonhuman primates under physiological conditions. This scanner is build by working groups of the Research Center Jülich (FZJ). The gantry allows rotation of the detector modules as well as tilting by 90 degrees to measure non-human primates in an upright sitting position. The opening diameter of the ring is variable between 130mm and 300mm, the axial detector length is 110mm.

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The ClearPET/spl trade/ LSO/LuYAP phoswich scanner: a high performance small animal PET system

Cited by 13 publications

References 10 publications

Quantitative preclinical PET imaging: opportunities and challenges

Quantitative preclinical PET imaging: opportunities and challenges

New embedded digital front-end for high resolution PET scanner

The ClearPET. Neuro scanner: A dedicated LSO/LuYAP phoswich small animal PET scanner

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