The Clearance of Major Components of Whole Blood From Cerebrospinal Fluid Following Simulated Subarachnoid Hemorrhage

Arachnoid clearance of red blood cells

“…The first is the recording of a minimal transfer of cells at low infusion pressures. This parallels the low blood levels in the studies of Dupont et al (1961), and indicates that relatively few intact cells enter the vascular compartment after some subarachnoid haemorrhages. Shabo and Maxwell (1968a) have suggested that hydrostatic force may rupture the arachnoid covering to account for cell movement.…”

“…The initial work of Simmonds indicated the transfer of approximately 15% of cisternal blood deposits (Simmonds, 1952(Simmonds, ,1953. Other later studies disclosed a range extending from 2-66% (Adams and Prawirohardjo, 1959;Dupont et al, 1961;Bradford and Johnson, 1962). In this work, we have re-evaluated the removal of subarachnoid blood by (1) testing the influences of hydrostatic force and of lavage, (2) measuring the uptake of radioactive label in various tissues, and (3) comparing the results with the use of red cell suspensions and simulated whole blood.…”

Electron Microscopic Observations on the Fate of Particulate Matter in the Cerebrospinal Fluid

“…The arachnoid cells apparently engulf the material and sequester it in vacuoles, presumably in preparation for lysosomal digestion (Figs. [4][5][6].…”

The role of the arachnoid villus in the removal of red blood cells from the subarachnoid space

“…Bradford and Johnson 3 repeated these experiments us-ing Cr ~1-and Fe59-1abeled erythrocytes and found a range of 5% to 65% of the intact cells in circulating blood in 24 hours. Du-Pont, et al, 6 however, found conflicting data; in their experiments less than 0.5% of the labeled erythrocytes entered the bloodstream in 48 hours. Partial explanation for the inconsistency can be found in a report by Adams and Prawirohardjo 1 who counted blood and spinal fluid 24 hours after tagged red cells were injected into the cisterna magna.…”