The classification of β‐adrenoceptors in isolated ring preparations of canine coronary arteries

O’Donnell, Stella R.; Wanstall, Janet C.

doi:10.1111/j.1476-5381.1984.tb16129.x

Cited by 41 publications

(20 citation statements)

References 21 publications

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“…This is in agreement with the result of McPherson and Bevan (12) that pKB values of both selective Q1 -adrenoceptor antagonists, betaxolol and metoprolol, were larger against the selective (31 -adrenoceptor agonist R0363 than against isoproterenol. The pA2 value of atenolol obtained in the present study was comparable to that ob tained by O'Donnell and Wanstall (29) in the canine coronary artery.…”

Section: Discussionsupporting

confidence: 79%

Heterogeneity of .BETA.-adrenoceptor in canine veins: Comparison among the facial, portal and saphenous veins.

Tsuru

Negita

1989

Jpn.J.Pharmacol

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Abstract-A study was made on the characteristics of 13-adrenoceptors in the isolated canine facial, portal and saphenous veins. Ring segments of the facial and saphenous veins and longitudinal strips of the portal vein were suspended in tissue baths containing Krebs solution oxygenated and maintained at 37'C. They were moderately contracted with prostaglandin F2a before examining their relaxation responses.The facial and saphenous veins fully relaxed to isoproterenol, while the aortal vein relaxed to a small extent (20% of maximum relaxation) even in the presence of an a-adrenoceptor blockade.In contrast, both forskolin, a direct activator of adenylate cyclase, and membrane-permeable dibutyryl cyclic AMP similarly relaxed all the veins studied.

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Section: Discussionsupporting

confidence: 79%

Heterogeneity of .BETA.-adrenoceptor in canine veins: Comparison among the facial, portal and saphenous veins.

Tsuru

Negita

1989

Jpn.J.Pharmacol

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“…The results of the current (Goldie et al, 1983), dog coronary artery (O'Donnell & Wanstall, 1984), rat atria (Bryan et al, 1981) and guinea-pig atria (O'Donnell & Wanstall, 1979) where populations of fi1-adrenoceptors reportedly predominate. Conversely, in human isolated bronchus (Goldie et al, 1984) and guinea-pig trachea (O'Donnell & Wanstall, 1979) where #2-adrenoceptors predominate, noradrenaline was about one tenth as potent as fenoterol in mediating relaxation.…”

Section: Discussionmentioning

confidence: 59%

β₁‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

Henry

Goldie

1990

British J Pharmacology

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“…Although propranolol has been reported to have membranestabilizing effects at higher doses, its inhibitory effect on nerve-mediated vasodilator responses is unlikely to be due to this as these responses were also significantly reduced by the equivalent dose of atenolol, which does not have membrane-stabilizing effects compared to propranolol (Weiner 1980b (Cohen & Wiley, 1978) have been shown to contain both types of pJadrenoceptors. As fll-adrenoceptors can be activated by noradrenaline, it has been suggested that these tissues may be 'functionally innervated' by sympathetic fibres (O'Donnell & Wanstall, 1984). If this is the case, it is possible that these receptors may have a role in modulating the constrictor response to noradrenaline mediated via xadrenoceptors.…”

Section: Discussionmentioning

confidence: 99%

Sympathetic innervation and beta‐adrenoceptor profile of blood vessels in the posterior region of the rabbit knee joint

Najafipour

Ferrell²

1993

Experimental Physiology

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SUMMARYExperiments were performed to investigate the presence and nature of f-adrenoceptors in blood vessels supplying the posterior capsule of the rabbit knee joint. Electrical stimulation of the posterior articular nerve (PAN) and close intra-arterial injection of adrenaline produced vasoconstriction which reversed to vasodilatation with administration of the a-adrenoceptor antagonist phenoxybenzamine. In almost all animals close intra-arterial injection of the /,-adrenoceptor agonist isoprenaline resulted in vasodilatation. Injection of the more selective ,1-agonists dobutamine, salbutamol and terbutaline also produced vasodilatation with a rank potency order of isoprenaline > dobutamine > salbutamol > terbutaline. The /-adrenoceptor antagonist propranolol abolished the dilator responses to adrenaline and isoprenaline, and significantly reduced the dilator responses to PAN stimulation in phenoxybenzamine-treated animals. Nerve-mediated vasodilatation was also reduced by the substance P antagonist D-Pro4 D-Trp7'9'10 SP4 -1, suggesting that substance P contributes to this dilatation. Dobutamine, a selective /31-agonist, produced vasodilatation which was abolished by administration of the selective /ll-antagonist atenolol. Isoprenaline-induced vasodilatation was substantially reduced by atenolol. The dilator response to isoprenaline appeared to be unaffected by the selective I82-antagonist ICI1 18551, but the weak dilator responses to the selective fl2-agonists salbutamol and terbutaline were significantly reduced by this antagonist. The results of this study suggest that /-adrenoceptors appear to be involved in the sympathetic regulation of rabbit knee joint blood flow, and that this is predominantly mediated via fll-adrenoceptors.

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The classification of β‐adrenoceptors in isolated ring preparations of canine coronary arteries

Cited by 41 publications

References 21 publications

Heterogeneity of .BETA.-adrenoceptor in canine veins: Comparison among the facial, portal and saphenous veins.

Heterogeneity of .BETA.-adrenoceptor in canine veins: Comparison among the facial, portal and saphenous veins.

β₁‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

Sympathetic innervation and beta‐adrenoceptor profile of blood vessels in the posterior region of the rabbit knee joint

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The classification of β‐adrenoceptors in isolated ring preparations of canine coronary arteries

Cited by 41 publications

References 21 publications

Heterogeneity of .BETA.-adrenoceptor in canine veins: Comparison among the facial, portal and saphenous veins.

Heterogeneity of .BETA.-adrenoceptor in canine veins: Comparison among the facial, portal and saphenous veins.

β1‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

Sympathetic innervation and beta‐adrenoceptor profile of blood vessels in the posterior region of the rabbit knee joint

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β₁‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea