In this paper we classify the centers, the cyclicity of its Hopf bifurcation and their isochronicity for the polynomial differential systems in R 2 of arbitrary degree d 3 odd that in complex notation z = x + iy can be written aṡwhere λ ∈ R and A, B, C , D ∈ C. If d = 3 we obtain the well-known class of all polynomial differential systems of the form a linear system with cubic homogeneous nonlinearities.