The classic cadherins in synaptic specificity

Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice

“…In addition to the role of -Cat in CDH-mediated cell adhesion, it also plays a critical role in the canonical Wnt signal transduction pathway, and the Wnt/-Cat complex is involved in modulating synaptic plasticity that is underlying long-term memory (Chen, Park, & Tang, 2006;Maguschak & Ressler, 2008. The remodeling and cell signaling capabilities of the CDH family molecules in the synaptic connections suggest that the CDH are important not only during synaptic assembly (Basu et al, 2015), but also in fine-tuning the synaptic response (Arikkath & Reichardt, 2008;Seong et al, 2015).…”

“…Given the possibility that dynamic modifications in expression of cell adhesion molecules are implicated both in memory (Basu et al, 2015;Maguschak & Ressler, 2008) and brain development (Paulson et al, 2014), a possible effect of CDH function on synaptic plasticity could be related to the stress responses later in life. Considering the stress-induced molecular changes on cell adhesion molecules, there are no studies that examined the sex-specific effects of MS on CDH mRNA expression in late adolescent BALB/c mice.…”

“…Classical cadherin (CDH) is a family of transmembrane proteins characterized by an extracellular domain containing five CDH repeat sequences mediating specific calcium-dependent interactions (Brasch, Harrison, Honig, & Shapiro, 2012). In addition, CDH adhesion molecules are grouped into type I and type II subfamily, playing an substantial role in the regulation of synaptic plasticity and MATERNAL SEPARATION, RECOGNITION MEMORY AND CADHERIN mRNA 6 specificity (Basu, Taylor, & Williams, 2015;Gärtner, Fornasiero, & Dotti, 2015;Seong, Yuan, & Arikkath, 2015;Takeichi, 2007). -Catenin (-Cat) is a cell adhesion molecule associated with the cytoplasmic domain of CDH and directly linked to the acting-binding proteins in synaptic junctions (McCrea, Maher, & Gottardi, 2015), regulating the synaptic connectivity and activity (Salinas & Price, 2005;Seong et al, 2015).…”

Regulation of neural circuit formation by protocadherins

“…Here, we review the data demonstrating roles for the clustered and non-clustered Pcdhs in axon outgrowth and targeting, dendrite arborization, and synaptogenesis, and highlight the evidence indicating their potential involvement in human neurodevelopmental and neurological disorders. Note that we focus here exclusively on the clustered Pcdhs and δ-Pcdhs, and on functions related to the establishment of neural circuitry; several other reviews can be consulted for other Pcdh roles [10-16] and for discussion of other cadherin superfamily molecules with roles in neural development [17-19]. …”

The role of Gpi-anchored axonal glycoproteins in neural development and neurological disorders

“…Morphoregulatory molecules may belong to distinct families of adhesion receptors, the main grouping being the Cadherins (Basu et al, 2015;Friedman et al, 2015;Gartner et al, 2015), the Integrins (Gardiner, 2011) and the Immunoglobulin superfamily (IgCAM, Maness and Schachner, 2007). Based on their interactions, these molecules may be differentially involved in distinct aspects of neural developmental control (Yogev and Shen, 2014).…”