The circulatory orbit of micro-RNAs in hepatitis C

Polyak, Stephen J.

doi:10.1002/hep.26508

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Only recently with interest in miRNAs as circulatory biomarkers have miRNAs been correlated with fibrosis in chronic liver diseases of varying aetiologies such as alcoholic liver disease (ALD) [56,57], non-alcoholic fatty liver disease (NAFLD) [58,59,60,61], chronic hepatitis C [58,62,63], chronic hepatitis B [64,65] or drug induced liver injury [66] to name a few. Most of these studies assessing the circulatory miRNA signature have been conducted in adult chronic liver diseases with a paucity of information available in the paediatric setting.…”

Section: Mirna Target Identificationmentioning

confidence: 99%

Function and Regulation of MicroRNAs and Their Potential as Biomarkers in Paediatric Liver Disease

Calvopina

Coleman

Lewindon

et al. 2016

IJMS

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MicroRNAs (miRNAs) are short non-coding RNAs involved in biological and pathological processes of every cell type, including liver cells. Transcribed from specific genes, miRNA precursors are processed in the cytoplasm into mature miRNAs and as part of the RNA-induced silencing complex (RISC) complex binds to messenger RNA (mRNA) by imperfect complementarity. This leads to the regulation of gene expression at a post-transcriptional level. The function of a number of different miRNAs in fibrogenesis associated with the progression of chronic liver disease has recently been elucidated. Furthermore, miRNAs have been shown to be both disease-and tissue-specific and are stable in the circulation, which has led to increasing investigation on their utility as biomarkers for the diagnosis of chronic liver diseases, including those in children. Here, we review the current knowledge on the biogenesis of microRNA, the mechanisms of translational repression and the use of miRNA as circulatory biomarkers in chronic paediatric liver diseases including cystic fibrosis associated liver disease, biliary atresia and viral hepatitis B.

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