The Circulation in Traumatic Shock

Blood Volume in Clinical Shock. I. Mixing Time and Disappearance Rate of T-1824 in Normal Subjects and in Patients in Shock; Determination of Plasma Volume in Man From 10-Minute Sample12

“…. Secondly, the prevalent hypothesis that shock is caused by a generalized increase in capillary permeability led to the belief that the dye escapes so rapidly from the bloodstream as to invalidate the measurement of plasma volume (8). Careful appraisal of plasma volume determinations with the dye method in dogs in which the full picture of shock was produced by trauma (9) has demonstrated that both of the above contentions are incorrect.…”