The Circulation in Malaria

Skirrow, M. B.; Chongsuphajaisiddhi, T; Maegraith, B. G.

doi:10.1080/00034983.1964.11686273

Cited by 51 publications

(2 citation statements)

References 15 publications

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“…2). Acute malaria in monkeys has been show portal venous vasoconstriction and a rise in portal sure (Skirrow et al, 1964); this may be a non-spe reaction to shock. If such a mechanism plays a transient splenomegaly of acute malaria in child have contributed to the rapid regression in size ( and liver in these cases.…”

Section: Discussionmentioning

confidence: 99%

Childhood splenomegaly in Uganda, and its relation to malaria.

Vanier¹,

Hutt²,

Cook³

1968

BMJ

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Gastric Surgery-Ashurst BiNL 649 wich " technique. In no case were circulating P.C.A. detected postoperatively that had not been found in the preoperative specimen. The incidence of P.C.A. was below the normal range for the age and sex of the patients, but 2 of 22 (9%) patients with gastric cancer showed circulating P.C.A. The failure to demonstrate circulating parietal-cell antibodies in serial specimens of serum taken from patients who had undergone gastric surgery does not support the hypothesis that autoimmunization, is the result of damage to the gastric mucosa.

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Section: Discussionmentioning

confidence: 99%

Childhood splenomegaly in Uganda, and its relation to malaria.

Vanier¹,

Hutt²,

Cook³

1968

BMJ

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“…Increased plasma PKa also was associated with a fall in plasma bradykininogen (HK) in infected animals ( Onabanjo and Maegraith, 1970c ). Finally, severe hypotension in rhesus monkeys infected with P. knowlesi was found to be accompanied by PK activation, cleavage of HK, and high BK levels ( Skirrow et al., 1964 ).…”

Section: Malaria Infection Induces Bradykinin Formation and Vascular ...mentioning

confidence: 99%

Is there a role for bradykinin in cerebral malaria pathogenesis?

Pinheiro

Kazura

Pinheiro

2023

Front. Cell. Infect. Microbiol.

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Malaria is a parasitic disease of global health significance and a leading cause of death in children living in endemic regions. Although various Plasmodium species are responsible for the disease, Plasmodium falciparum infection accounts for most severe cases of the disease in humans. The mechanisms of cerebral malaria pathogenesis have been studied extensively in humans and animal malaria models; however, it is far from being fully understood. Recent discoveries indicate a potential role of bradykinin and the kallikrein kinin system in the pathogenesis of cerebral malaria. The aim of this review is to highlight how bradykinin is formed in cerebral malaria and how it may impact cerebral blood-brain barrier function. Areas of interest in this context include Plasmodium parasite enzymes that directly generate bradykinin from plasma protein precursors, cytoadhesion of P. falciparum infected red blood cells to brain endothelial cells, and endothelial cell blood-brain barrier disruption.

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Acute Renal Failure in Plasmodium falciparum Malaria

Canfield¹

1968

Arch Intern Med

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The Circulation in Malaria

Cited by 51 publications

References 15 publications

Childhood splenomegaly in Uganda, and its relation to malaria.

Childhood splenomegaly in Uganda, and its relation to malaria.

Is there a role for bradykinin in cerebral malaria pathogenesis?

Acute Renal Failure in Plasmodium falciparum Malaria

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