The circulating level of MMP-9 and its ratio to TIMP-1 as a predictor of severity in patients with community-acquired pneumonia

Chiang, Ting Yen; Yu, Yung Luen; Lin, Chiao‐Wen; Tsao, Shih Ming; Yang, Shun Fa; Yeh, Chao‐Bin

doi:10.1016/j.cca.2013.06.013

Cited by 23 publications

(22 citation statements)

References 33 publications

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“…We performed a zymographic analysis to determine active and inactive MMPs in the serums of CAP patients and controls. Active forms of MMP-2 and MMP-9 were 13 and 17 times higher, respectively, in CAP patients than controls, making our findings consistent with the results of previous studies (6,23,24,(26)(27)(28).…”

Section: Discussionsupporting

confidence: 92%

“…Serum levels of MMP-2, MMP-9, TIMP-1, and α-2 macroglobulin, and the ratio of MMP-9/TIMP-1 according to the some clinical criteria. (29) 191.9 ± 9.5 222. positively correlates with pneumonia severity indexes (PSI, CURB, and APACHE II) and length of hospital stay (27). Our results support this finding that patients with severe CAP have higher serum TIMP-1 levels and that protease/antiprotease imbalance is more prominent in severe CAP cases.…”

Section: Discussionsupporting

confidence: 85%

“…In contrast to these findings, however, we found no significant correlation between MMPs and leukocytes in the serum, although we did obtain similar results to those of Chiang et al (27), namely that MMP-9 and TIMP-1 serum levels and CRP, leukocyte, and neutrophil counts decreased following successful antibiotic treatment. In our study, we observed an increase in serum levels of MMP-2 in patients with CAP after successful antibiotic treatment.…”

Section: Discussioncontrasting

confidence: 58%

“…However, only a few studies in the literature have investigated the role of MMPs in pneumonia pathogenesis (6,(22)(23)(24)(26)(27)(28). These have shown that patients with hospital-acquired pneumonia (HAP) have excessive MMP-8 and -9 concentrations in plasma and mini-BAL fluids compared to healthy controls (22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

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Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Bircan¹,

Çakır²,

Kapulu³

et al. 2015

Turk J Med Sci

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Background/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP).Materials and methods: Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre-and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography.Results: MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P < 0.001 and P < 0.001, respectively). Low-risk patients had lower levels of MMP-2 and TIMP-1 than high-risk patients (P = 0.044, P = 0.001, respectively). Pretreatment serum TIMP-1 level was higher in patients with TCS of >3 days (P = 0.004) and was correlated with oxygenation and PSI scores. Posttreatment serum levels of MMP-9 and TIMP-1 were decreased after antibiotics (P = 0.0001 and P = 0.017, respectively). Conclusion:Although MMP-2, MMP-9, and TIMP-1 correlate with many poor prognostic factors, more studies are required to prove their possible role in predicting the severity of CAP.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 85%

Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

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Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Bircan¹,

Çakır²,

Kapulu³

et al. 2015

Turk J Med Sci

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“…CAP has also been associated with higher MMP-9 expression which correlated with an increase in the neutrophil count (109). This has led to the suggestion that plasma MMP-9 levels, and the molar ratio of MMP-9 to its cognate TIMP-1, could be used in the clinical evaluation of pneumonia diagnosis (115).…”

Section: Common Markers Of Copd and Pneumoniamentioning

confidence: 99%

Convergence in the Epidemiology and Pathogenesis of COPD and Pneumonia

Gautam

O’Toole

2016

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Chronic obstructive pulmonary disease (COPD) is one of the main causes of human mortalities globally after heart disease and stroke. There is increasing evidence of an aetiological association between COPD and pneumonia, the leading infectious cause of death globally in children under 5 years. In this review, we discuss the known risk factors of COPD that are also shared with pneumonia including smoking, air pollution, age and immune suppression. We review how lung pathology linked to a previous history of pneumonia may heighten susceptibility to the development of COPD in later life. Furthermore, we examine how specific aspects of COPD immunology could contribute to the manifestation of pneumonia. Based on the available evidence, a convergent relationship is becoming apparent with respect to the pathogenesis of COPD and pneumonia. This has implications for the management of both diseases, and the development of new interventions.

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Plasma MMP2/TIMP4 Ratio at Follow-up Assessment Predicts Disease Progression of Idiopathic Pulmonary Arterial Hypertension

Wetzl

Tiede

Faerber

et al. 2017

Lung

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The circulating level of MMP-9 and its ratio to TIMP-1 as a predictor of severity in patients with community-acquired pneumonia

Cited by 23 publications

References 33 publications

Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Convergence in the Epidemiology and Pathogenesis of COPD and Pneumonia

Plasma MMP2/TIMP4 Ratio at Follow-up Assessment Predicts Disease Progression of Idiopathic Pulmonary Arterial Hypertension

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