The Circular RNA circSKA3 Facilitates the Malignant Biological Behaviors of Medulloblastoma via miR-520 h/CDK6 Pathway

Liu, Xu-Chang; Wang, Fachen; Wang, Jihong; Zhao, Junyan; Ye, Si-Yong

doi:10.1007/s12033-022-00466-4

Cited by 5 publications

(12 citation statements)

References 24 publications

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“…CircSKA3 was the only circRNA found to be deregulated in more than two different studies, being analyzed in four out of the seven studies. Interestingly, circSKA3 was upregulated in all of them [31][32][33][34]. Moreover, circSMARCA5, circLPAR1, circFAM13B, and circHIPK3 were analyzed in two different studies and were found to be downregulated in the MB group compared with healthy controls in both studies [35,36] (Table 2).…”

Section: Circrnasmentioning

confidence: 98%

“…In these studies, the role of circSKA3 was studied in different cancer phenotypes through overexpression and/or silencing studies in MB cell lines. Two articles were evaluated as Q2 [31,34], while the remaining articles were evaluated as Q3 and Q1 [32,33] (Table 5). −: reduced proliferation/apoptosis/invasion/migration/cell cycle arrest rates when circSKA3 is overexpressed/knocked down; +: increased proliferation/apoptosis/invasion/migration/cell cycle arrest rates when circSKA3 is overexpressed/silenced; NA: information not available.…”

Section: Circrnasmentioning

confidence: 99%

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The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review

Martinez de Estibariz,

Jakjimovska,

Illarregi

et al. 2023

Cancers

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Medulloblastoma (MB) is the most common malignant brain tumor in childhood. Although recent multi-omic studies have led to advances in MB classification, there is still room for improvement with regard to treatment response and survival. Therefore, identification of new and less invasive biomarkers is needed to refine the diagnostic process and to develop more personalized treatment strategies. In this context, non-coding RNAs (ncRNAs) could be useful biomarkers for MB. In this article, we reviewed the role of two types of ncRNAs, long non-coding (lncRNAs) and circular RNAs (circRNAs), as biomarkers for the diagnosis, subgroup classification, and prognosis of MB. We also reviewed potential candidates with specific functions and mechanisms of action in the disease. We performed a search in PubMed and Scopus using the terms (“long non coding RNAs” OR ”lncRNAs”) and (“circular RNAs” OR ”circRNAs”) AND ”medulloblastoma” to identify biomarker discovery or functional studies evaluating the effects of these ncRNAs in MB. A total of 26 articles met the inclusion criteria. Among the lncRNAs, the tumorigenic effects of the upregulated lnc-IRX3-80 and lnc-LRRC47-78 were the most studied in MB. Among the circRNAs, the upregulation of circSKA3 and its functional impact in MB cell lines were the most consistent results, so this circRNA could be considered a potential biomarker in MB. Additional validation is required for many deregulated lncRNAs and circRNAs; therefore, further studies are warranted.

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Section: Circrnasmentioning

confidence: 98%

Section: Circrnasmentioning

confidence: 99%

The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review

Martinez de Estibariz,

Jakjimovska,

Illarregi

et al. 2023

Cancers

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“…One example is the study by Galardi et al describing the crucial role of circRNAs in pediatric tumors [42]. Among the most promising circRNAs reported, circSKA3 plays a crucial role in promoting cell proliferation in medulloblastoma, one of the most common brain tumors in children, by sponging miR-383-5p, miR-326 and miR-520 h [43][44][45]. Similarly, hsa_circ_0000527 and hsa_circ_0000034 stimulate the proliferation and invasion of retinoblastoma tumor cells by sponging miR-646 and miR-361-3p, respectively [46][47][48].…”

Section: Biological Functionmentioning

confidence: 99%

Plasma Circular RNAs as Biomarkers for Breast Cancer

Tierno,

Grassi,

Zanconati

et al. 2024

Biomedicines

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Breast cancer (BC) is currently the most common neoplasm, the second leading cause of cancer death in women worldwide, and is a major health problem. The discovery of new biomarkers is crucial to improve our knowledge of breast cancer and strengthen our clinical approaches to diagnosis, prognosis, and follow-up. In recent decades, there has been increasing interest in circulating RNA (circRNA) as modulators of gene expression involved in tumor development and progression. The study of circulating circRNAs (ccircRNAs) in plasma may provide new non-invasive diagnostic, prognostic, and predictive biomarkers for BC. This review describes the latest findings on BC-associated ccircRNAs in plasma and their clinical utility. Several ccircRNAs in plasma have shown great potential as BC biomarkers, especially from a diagnostic point of view. Mechanistically, most of the reported BC-associated ccircRNAs are involved in the regulation of cell survival, proliferation, and invasion, mainly via MAPK/AKT signaling pathways. However, the study of circRNAs is a relatively new area of research, and a larger number of studies will be crucial to confirm their potential as plasma biomarkers and to understand their involvement in BC.

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“…Last year, it was demonstrated that circ-SKA3 decoyed miR-326 to increase the ID3 expression leading to cell proliferation, migration, and invasion in MB [32]. Moreover, it was observed that circSKA3 expression in MB tissues was negatively correlated with the miR-520 expression and positively correlated with the CDK6 expression, suggesting that circSKA3 facilitates MB progression through the miR-520 h/CDK6 axis [33].…”

Section: Medulloblastomamentioning

confidence: 99%

An Update on Circular RNA in Pediatric Cancers

et al. 2022

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Circular RNAs (circRNAs) are a class of single-stranded closed noncoding RNA molecules which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, only recently there appeared an increased interest in the understanding of their regulatory importance. Among their most relevant characteristics are high stability, abundance and evolutionary conservation among species. CircRNAs are implicated in several cellular functions, ranging from miRNA and protein sponges to transcriptional modulation and splicing. Additionally, circRNAs’ aberrant expression in pathological conditions is bringing to light their possible use as diagnostic and prognostic biomarkers. Their use as indicator molecules of pathological changes is also supported by their peculiar covalent closed cyclic structure which bestows resistance to RNases. Their regulatory role in cancer pathogenesis and metastasis is supported by studies involving human tumors that have investigated different expression profiles of these molecules. As endogenous competitive RNA, circRNAs can regulate tumor proliferation and invasion and they arouse great consideration as potential therapeutic biomarkers and targets for cancer. In this review, we describe the most recent findings on circRNAs in the most common pediatric solid cancers (such as brain tumors, neuroblastomas, and sarcomas) and in more rare ones (such as Wilms tumors, hepatoblastomas, and retinoblastomas).

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The Circular RNA circSKA3 Facilitates the Malignant Biological Behaviors of Medulloblastoma via miR-520 h/CDK6 Pathway

Cited by 5 publications

References 24 publications

The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review

The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review

Plasma Circular RNAs as Biomarkers for Breast Cancer

An Update on Circular RNA in Pediatric Cancers

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