This investigation explores the evolving landscape of waste management in the hotel industry, emphasizing the pivotal role of sustainability. Smart waste management systems, powered by data analytics and IoT, revolutionize trash monitoring, enhancing operational efficiency. Blockchain ensures transparency, fostering responsibility throughout the supply chain. Material science innovations, aligned with the circular economy, drive a shift to biodegradable materials. 3D printing transforms on-site amenities, reducing packaging and transit impact. The industry, adapting to consumer sustainability preferences, promotes responsible consumption through guest empowerment and innovative engagement strategies. As hotels integrate AI for zero-waste practices, this chapter serves as a comprehensive guide for academia, policymakers, and industry experts navigating toward a more sustainable future.