The Circadian Rhythm of Osteoprotegerin and Its Association with Parathyroid Hormone Secretion

Joseph, Franklin; Chan, B.Y.; Durham, B; Ahmad, Aftab; Vinjamuri, Sobhan; Gallagher, James A.; Vora, Jiten; Fraser, William D.

doi:10.1210/jc.2006-1832

Cited by 47 publications

(38 citation statements)

References 74 publications

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“…Available information on variation of circulating OPG along the 24-h cycle is scanty and contradictory. Joseph et al [15] did find a significant rhythmicity for OPG in a group of four men and four women. In a group of six women and three men, Tarquini et al [16] found a circasemidian, rather than circadian, variation in circulating OPG, with a quite small amplitude (<5%); we failed to confirm such a circasemidian rhythm in our population.…”

Section: Discussionmentioning

confidence: 89%

“…With regard to serum levels of sRANKL and OPG, variability along the 24-h cycle should be taken into account when they are investigated as markers of skeletal or vascular diseases. Only a few studies have addressed the issue of possible rhythmicity of circulating OPG [15][16][17], whereas there are no data on serum sRANKL. The aim of the study was to assess the variability of OPG and sRANKL serum levels along the 24-h cycle in healthy women.…”

Section: Introductionmentioning

confidence: 99%

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Variations along the 24-hour cycle of circulating osteoprotegerin and soluble RANKL: a rhythmometric analysis

et al. 2007

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Summary The variability of serum osteoprotegerin (OPG) and soluble RANKL (sRANKL) along the 24-h cycle was assessed in 20 healthy women. No rhythmic variations of serum OPG, sRANKL or sRANKL/OPG ratio were detected as a group phenomenon. Timing of sampling is unlikely to influence the results of measurements of circulating OPG and sRANKL. Introduction Physiological bone turnover shows diurnal variations. The aim of the study was to assess variability of OPG and sRANKL serum levels along the 24-h cycle. Methods Blood was collected from 20 healthy women (median age 31 years, range 25-65 years) at 4-h intervals between 08:00 and 24:00 and at 2-h intervals between 24:00 and 08:00. Serum albumin, cortisol, osteocalcin (OC), Cterminal telopeptide of type I collagen (CTX), OPG and total sRANKL were measured. Temporal variations were assessed by the COSINOR model. Results Circadian rhythms of cortisol and albumin documented a normal synchronization within the circadian structure. Serum OC and CTX showed rhythmic variations, peaking at night-time. Rhythmic variations of serum OPG, sRANKL and sRANKL/OPG ratio were not detected as a group phenomenon. On an individual basis, rhythmic changes were detected in ten patients for OPG and eight patients for sRANKL, with very small amplitudes and heterogeneous acrophases. Conclusions The absence of consistent rhythmic variations of circulating OPG and sRANKL levels may reflect the absence of rhythmic variations of their expression in the bone microenvironment. Were this the case, the nocturnal rise of bone resorption should be accounted for by different, not RANKL/OPG-mediated factors. Since circulating OPG and sRANKL may derive from sources other than bone, rhythmicity could be masked by non-rhythmic or nonsynchronized rhythmic expression in these sources. Timing of sampling is unlikely to influence the results of measurements of circulating OPG and sRANKL.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Variations along the 24-hour cycle of circulating osteoprotegerin and soluble RANKL: a rhythmometric analysis

et al. 2007

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“…Most studies reported a circadian bimodal rhythm with a nocturnal acrophase, a mid-morning nadir and a smaller afternoon peak (Table 5). Peak times varied between studies and were affected by gender [75,77]. There was also interindividual variability in the return to baseline (between 06:00 and 10:00) [81,91].…”

Section: Circadian Variationmentioning

confidence: 99%

“…There was also interindividual variability in the return to baseline (between 06:00 and 10:00) [81,91]. Most studies reported a circadian amplitude amongst healthy individuals of between 0.3 and 0.8 pmol/L [64,66,68,69,72,73,75,77,79,81,82,90] although higher amplitudes of 1.2 [73] and 1.9 [68] pmol/L, respectively, were also reported. Circadian variation was absent in patients with thalassemia [70] and primary hyperparathyroidism [80,81].…”

Section: Circadian Variationmentioning

confidence: 99%

“…Logue et al [81] recommend that blood samples should be collected between 10:00 and 16:00 and results interpreted against a reference range based on this [65] 12.00-20.00 -20.00 08.00 Calvo et al [67] 02.00-04.00 18.00-20.00 18.00 and 02.00 10.00 and 20.00 Chapotot et al [68] 23.00-07.00 15.00-23.00 --El-Hajj et al [69] 01.00-03.00 17.30 03.14 10.00-11.00 Fraser et al [71] 22.00-07.00 14.00-22.00 06.12 09.30-10.30 Generali et al [72] --17.15 -Greenspan et al [74] 03.20 15.20 -12.00 Greenspan et al [75] 23.35 ± 05.25 , 20.30 ± 02.10 ---Herfarth et al [76] No night samples P.M. 14.00 09.30 Joseph et al [77] 22.00-24.00 , 24.00-02.00 14.00-17.00 09.46-13.15 , 10.45-13.25 -Jubiz et al [78] 02.00-04.00 --08.00 Kitamura et al [79] A.M. -23.00 ± 4 -Logue et al [82] 02.00-06.00 -04.05 10.00 Logue et al [81] A.M. -04.05 09.30 Markowitz et al [83] 04.00 20.00 --Nielsen et al [84] P.M. sampling time. Since the data were derived using first or second generation assays, it is possible that the reported diurnal variation of PTH could reflect differential clearance of PTH fragments over a 24 h period, e.g., with reduced renal clearance of (7-84) PTH at night reflecting decreased glomerular filtration rate at night [92].…”

Section: Circadian Variationmentioning

confidence: 99%

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Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review

Hanon

Sturgeon

Lamb

2013

Clinical Chemistry and Laboratory Medicine (CCLM)

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Parathyroid hormone (PTH) is relatively unstable: optimisation of pre-analytical conditions, including specimen type, sampling time and storage conditions, is essential. We have undertaken a systematic review of these pre-analytical conditions. An electronic search of the PubMed, Embase, Cochrane, Centre for Research and Dissemination and Bandolier databases was undertaken. Of 5511 papers identified, 96 underwent full text review, of which 83 were finally included. At room temperature PTH was stable in ethylenediaminetetraacetic acid (EDTA) preserved whole blood for at least 24 h and in EDTA plasma for at least 48 h after venepuncture. Losses were observed in clotted blood samples after 3 h and in serum after 2 h. At 4°C PTH was more stable in EDTA plasma (at least 72 h) than serum (at least 24 h). Central venous PTH concentrations were higher than peripheral venous concentrations. In the northern hemisphere, PTH concentrations were higher in winter than summer. PTH has a circadian rhythm characterised by a nocturnal acrophase and mid-morning nadir. Data related to frozen storage of PTH (−20°C and −80°C) were limited and contradictory. We recommend that blood samples for PTH measurement should be taken into tubes containing EDTA, ideally between 10:00 and 16:00, and plasma separated within 24 h of venepuncture. Plasma samples should be stored at 4°C and analysed within 72 h of venepuncture. Particular regard must be paid to the venepuncture site when interpreting PTH concentration. Further research is required to clarify the suitability of freezing samples prior to PTH measurement.

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The circadian rhythm of calcium and bone homeostasis in Maasai

Schou

Jørgensen

Maro

et al. 2022

American J Hum Biol

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Objectives: Ethnic groups differ in prevalence of calcium-related diseases. Differences in the physiology and the endogenous circadian rhythm (CR) of calcium and bone homeostasis may play a role. Thus, we aimed to investigate details of CR pattern in calcium and bone homeostasis in East African Maasai.Methods: Ten clinically healthy adult Maasai men and women from Tanzania were examined. Blood samples were collected every 2nd hour for 24 h. Serum levels of total calcium, albumin, parathyroid hormone (PTH), 25(OH)D, creatinine, C-terminal telopeptide (CTX), bone-specific alkaline phosphatase (BSAP), procollagen type 1 N-terminal propeptide (P1NP), and osteocalcin were measured. Circadian patterns were derived from graphic curves of medians, and rhythmicity was assessed with Fourier analysis. Results: PTH-levels varied over the 24 h exhibiting a bimodal pattern. Nadir level corresponded to 65% of total 24-h mean. CTX and P1NP showed 24-h variations with a morning nadir and nocturnal peak with nadir levels corresponding to 23% and 79% of the 24-h mean, respectively. Albumincorrected calcium level was held in a narrow range and alterations were corresponding to alterations in PTH. There was no distinct pattern in 24-h variations of 25(OH)D, creatinine, osteocalcin, or BSAP. Conclusions: All participants showed pronounced 24-h variations in PTH and bone turnover markers CTX and P1NP. These findings support that Maasai participants included in this study have typical patterns of CR in calcium and bone homeostasis consistent with findings from other ethnic populations.

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The Circadian Rhythm of Osteoprotegerin and Its Association with Parathyroid Hormone Secretion

Cited by 47 publications

References 74 publications

Variations along the 24-hour cycle of circulating osteoprotegerin and soluble RANKL: a rhythmometric analysis

Variations along the 24-hour cycle of circulating osteoprotegerin and soluble RANKL: a rhythmometric analysis

Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review

The circadian rhythm of calcium and bone homeostasis in Maasai

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