The circadian clock remains intact, but with dampened hormonal output in heart failure

Crnko, Sandra; Printezi, Markella I; Zwetsloot, Peter-Paul M.; Leiteris, Laurynas; Lumley, Andrew I.; Zhang, Lu; Ernens, Isabelle; Jansen, Tijn P.J.; Homsma, Lilian; Feyen, Dries; Faassen, Martijn van; Pré, Bastiaan C. du; Gaillard, Carlo A. J. M.; Kemperman, Hans; Oerlemans, M. I. F. J.; Doevendans, Pieter A.; May, Anne M.; Zuithoff, Nicolaas P.A.; Sluijter, Joost P. G.; Devaux, Yvan; Laake, Linda W. van

doi:10.1016/j.ebiom.2023.104556

Cited by 9 publications

(5 citation statements)

References 44 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…147 Additional findings based on the study of a zebrafish (Danio rerio) model of heart failure (another diurnal vertebrate) were consistent with the concept of preserved peripheral clocks during heart failure. 147…”

Section: Myocardial Infarctionsupporting

confidence: 55%

“…147 In heart failure in humans, it has been suggested that the central circadian clock may be functioning at reduced output, while peripheral clocks may be intact. 147 Additional findings based on the study of a zebrafish (Danio rerio) model of heart failure (another diurnal vertebrate) were consistent with the concept of preserved peripheral clocks during heart failure. 147…”

Section: Myocardial Infarctionmentioning

confidence: 99%

“…145 Heart failure has been linked to abnormal diurnal patterns in BP, 141,146 including a high incidence of nondipping BP. 82,147 For example, a relatively small percentage of individuals with heart failure exhibited a normal dipping pattern. In contrast, almost 60% were nondippers and 20% were reverse dippers.…”

Section: Myocardial Infarctionmentioning

confidence: 99%

“…In contrast, almost 60% were nondippers and 20% were reverse dippers. 147 During heart failure, select changes in clock gene expression and daily rhythms remained intact, despite differences in BP dipping. 147 These latter changes were associated with reduced nocturnal levels of melatonin but increased 24-hour average levels of cortisol.…”

Section: Myocardial Infarctionmentioning

confidence: 99%

“…147 During heart failure, select changes in clock gene expression and daily rhythms remained intact, despite differences in BP dipping. 147 These latter changes were associated with reduced nocturnal levels of melatonin but increased 24-hour average levels of cortisol. 147 In heart failure in humans, it has been suggested that the central circadian clock may be functioning at reduced output, while peripheral clocks may be intact.…”

Section: Myocardial Infarctionmentioning

confidence: 99%

See 4 more Smart Citations

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Faraci,

Scheer

2024

Circulation Research

View full text Add to dashboard Cite

Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of the disease, the role of circadian biology has been relatively overlooked in both preclinical models and humans. Although the presence of daily and circadian patterns has been observed from the level of the genome to the whole organism, the functional and structural impact of biological rhythms, including mechanisms such as circadian misalignment, remains relatively poorly defined. Here, we review the impact of daily rhythms and circadian systems in regulating blood pressure and the onset, progression, and consequences of hypertension. There is an emphasis on the impact of circadian biology in relation to vascular disease and end-organ effects that, individually or in combination, contribute to complex phenotypes such as cognitive decline and the loss of cardiac and brain health. Despite effective treatment options for some individuals, control of blood pressure remains inadequate in a substantial portion of the hypertensive population. Greater insight into circadian biology may form a foundation for novel and more widely effective molecular therapies or interventions to help in the prevention, treatment, and management of hypertension and its related pathophysiology.

show abstract

Section: Myocardial Infarctionsupporting

confidence: 55%