The Circadian Clock in Oral Health and Diseases

Papagerakis, Silvana; Zheng, Li; Schnell, Santiago; Sartor, MA; Somers, Emily C.; Marder, Wendy; McAlpin, Blake; Kim, D; McHugh, Jonathan B.; Papagerakis, Pétros

doi:10.1177/0022034513505768

Cited by 66 publications

(69 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The finding of "endoplasmic reticulum membrane" as the top gene set associated with severe periodontitis parallels recent emerging data on the importance of endoplasmic reticulum stress in periodontitis (Domon et al, 2009;Lee et al, 2012). "Circadian clock rhythm" was the top enriched pathway for high colonization with red complex pathogens and has gained recent attention in oral health research (Papagerakis et al, 2014). Interestingly, Keller et al (2009) recently reported that on the molecular level, >8% of the macrophage transcriptome oscillates in a circadian fashion, including many important regulators for pathogen recognition and cytokine secretion.…”

Section: Discussionmentioning

confidence: 58%

Chronic Periodontitis Genome-wide Association Studies

et al. 2014

View full text Add to dashboard Cite

Recent genome-wide association studies (GWAS) of chronic periodontitis (CP) offer rich data sources for the investigation of candidate genes, functional elements, and pathways. We used GWAS data of CP ( n = 4,504) and periodontal pathogen colonization ( n = 1,020) from a cohort of adult Americans of European descent participating in the Atherosclerosis Risk in Communities study and employed a MAGENTA approach ( i.e., meta-analysis gene set enrichment of variant associations) to obtain gene-centric and gene set association results corrected for gene size, number of single-nucleotide polymorphisms, and local linkage disequilibrium characteristics based on the human genome build 18 (National Center for Biotechnology Information build 36). We used the Gene Ontology, Ingenuity, KEGG, Panther, Reactome, and Biocarta databases for gene set enrichment analyses. Six genes showed evidence of statistically significant association: 4 with severe CP ( NIN, p = 1.6 × 10−7; ABHD12B, p = 3.6 × 10−7; WHAMM, p = 1.7 × 10−6; AP3B2, p = 2.2 × 10−6) and 2 with high periodontal pathogen colonization (red complex– KCNK1, p = 3.4 × 10−7; Porphyromonas gingivalis–DAB2IP, p = 1.0 × 10−6). Top-ranked genes for moderate CP were HGD ( p = 1.4 × 10−5), ZNF675 ( p = 1.5 × 10−5), TNFRSF10C ( p = 2.0 × 10−5), and EMR1 ( p = 2.0 × 10−5). Loci containing NIN, EMR1, KCNK1, and DAB2IP had showed suggestive evidence of association in the earlier single-nucleotide polymorphism–based analyses, whereas WHAMM and AP2B2 emerged as novel candidates. The top gene sets included severe CP (“endoplasmic reticulum membrane,” “cytochrome P450,” “microsome,” and “oxidation reduction”) and moderate CP (“regulation of gene expression,” “zinc ion binding,” “BMP signaling pathway,” and “ruffle”). Gene-centric analyses offer a promising avenue for efficient interrogation of large-scale GWAS data. These results highlight genes in previously identified loci and new candidate genes and pathways possibly associated with CP, which will need to be validated via replication and mechanistic studies.

show abstract

Section: Discussionmentioning

confidence: 58%

Chronic Periodontitis Genome-wide Association Studies

et al. 2014

View full text Add to dashboard Cite

show abstract

“…It is anticipated that circadian clock research will contribute to broader understanding of how mineralized tissues are formed. A system’s biology approach having as “skeleton” the circadian system may help us understand how mineralized tissues are developed in synchrony [17]. New inputs such as mastication or bone load could be established in the circadian system equation increasing our understanding of this complex communication between the brain and the peripheral organs.…”

Section: Discussionmentioning

confidence: 99%

“…In oral health, the possibilities of clock genes involvement into patho-physiology of oral and craniofacial tissues remain largely unexplored [17]. This review summarizes the potential roles of clock genes in dental tissues formation with a special focus on enamel development.…”

Section: Introduction To the Circadian Clockmentioning

confidence: 99%

The tick tock of odontogenesis

Zheng

Ehardt

McAlpin

et al. 2014

Experimental Cell Research

View full text Add to dashboard Cite

Although a big deal of dental research is being focused to the understanding of early stages of tooth development, a huge gap exist on our knowledge on how the dental hard tissues are formed and how this process is controlled daily in order to produce very complex and diverse tooth shapes adapted for specific functions. Emerging evidence suggests that clock genes, a family of genes that controls circadian functions within our bodies, regulate also dental mineralized tissues formation. Enamel formation, for example, is subjected to rhythmical molecular signals that occur on short (24 hour) periods and control the secretion and maturation of the enamel matrix. Accordingly, gene expression and ameloblast functions are also tightly modulated in regular daily intervals. This review summarizes the current knowledge on the circadian controls of dental mineralized tissues development with a special emphasis on amelogenesis.

show abstract

“…All circadian rhythms are directed by the biological clock located in the hypothalamus, and interfere with the salivary flow, the oral epithelium, and inflammatory response, even in the IL-6 route 122 . BMS patients have low serum IL-6 levels, which play a neuroprotective role in the trigeminal nociceptive pathway through the underlying mechanisms thereof remain to be ellucidated 117 .…”

Section: Chronobiologymentioning

confidence: 99%

Burning Mouth Syndrome –Latest update

Tomattis¹,

Munerato²

2016

Int J Dentistry Res

View full text Add to dashboard Cite

Introduction: Burning mouth syndrome (BMS) is characterized by a recurrent daily burning sensation with no evidence lesions in the oral mucosa. It is accompanied by subjective dry mouth and dysgeusia. The tongue is the most commonly affected site, but the condition also affects other sites in the mouth. Its etiopathogeny is multifactorial and its diagnosis is made by exclusion. Objective: This article reviews the literature about the epidemiology, etiopathogeny, and diagnosis of BMS in the past 15 years. Articles were selected from PubMed/MEDLINE, and included clinical assays, case reports, and reviews. We found 509 articles, and only 136 were chosen. The key words were: burning mouth syndrome (BMS), review, etiopathogeny, diagnosis. Conclusions: BMS remains an important diagnostic challenge, though the disease is considered a neuropathy characterized by damage to trigeminal peripheral nervous fibers, which triggers central sensitization. In addition to BMS and secondary BMS, it seems relevant to include complicated BMS, in which symptoms persist despite the elimination of local and systemic causes. BMS should be investigated by a transdisciplinary team that will take into account all aspects active in the mental and physical dimensions of the condition, in the most detailed way. Therefore, QST, imaging investigations, various evaluation scales of mental health and of the impact of BMS on quality of life as well as the investigation of sleep disorders and changes in circadian rhythm could be useful tools in the development of treatment strategies based on findings and observing the characteristics of each BMS patient in light of specifics of diagnosis.

show abstract

The Circadian Clock in Oral Health and Diseases

Cited by 66 publications

References 64 publications

Chronic Periodontitis Genome-wide Association Studies

Chronic Periodontitis Genome-wide Association Studies

The tick tock of odontogenesis

Burning Mouth Syndrome –Latest update

Contact Info

Product

Resources

About