The cingulum bundle: Anatomy, function, and dysfunction

Bubb, Emma J.; Metzler‐Baddeley, Claudia; Aggleton, John P.

doi:10.1016/j.neubiorev.2018.05.008

Cited by 540 publications

(477 citation statements)

References 345 publications

(587 reference statements)

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“…In addition, we observed positive associations between LMI and white matter regional volumes. These associations with white matter volume were found in regions overlapping with the following tracts: anterior thalamic radiation (eg, superior frontal gyrus), which carries fibres between prefrontal cortex and thalamus and has been related to executive function and planning complex behaviours; cingulum bundle (ie, superior fronto‐medial gyrus and medial cingulate gyrus), which interconnects frontal, parietal, and medial temporal sites and relates to emotion, reward, pain, motor, conflict, error detection and memory; inferior fronto‐occipital fasciculus (ie, middle fronto‐orbital gyrus and putamen), a long association bundle that connects occipital cortex, temporobasal areas and superior parietal lobe to the frontal lobe and seems to play a key role in visual processing, attention and reading; superior longitudinal fasciculus (eg, inferior parietal gyrus), a large bundle of association fibres connecting the temporal, occipital and parietal lobes with ipsilateral frontal cortices necessary for language, emotions, memory and attention and corticospinal (two regions within the cerebellum VIII), concerned with motor function from the motor cortex to the spinal cord …”

Section: Discussionmentioning

confidence: 99%

Lean mass index is positively associated with white matter volumes in several brain regions in children with overweight/obesity

et al. 2020

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Summary Background The relationship of obesity with grey and white matter volumes has been examined in several studies, and the results are decidedly mixed. Objective To investigate the associations of body mass index (BMI), fat mass index (FMI) and lean mass index (LMI) with total and regional grey and white matter volumes. Methods This is a cross‐sectional study involving 100 children (60% boys) with overweight/obesity. T1‐weighted images were acquired using magnetic resonance imaging. Dual energy X‐ray absorptiometry was used to measure body composition. Separate hierarchical regression analyses were performed between predictor variables (BMI, FMI and LMI) and the total brain volumes including sex, years from peak height velocity and parental education as covariates. In addition, FMI was added as a covariate when LMI was the predictor and vice versa. Statistical analyses of imaging data were performed using three whole‐brain voxel‐wise multiple regression models and adjusted by the same covariates. Results LMI was positively associated with white matter in numerous regions and to a lower extent, with grey matter regions. Further, the relationship between LMI, and grey and white matter regions was independent of FMI levels. Conclusions LMI seems to be a positive predictor of regional white matter volumes in children with overweight/obesity.

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Section: Discussionmentioning

confidence: 99%

Lean mass index is positively associated with white matter volumes in several brain regions in children with overweight/obesity

et al. 2020

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“…Our results suggest that the rCAB may play an important role in ADHD. As a whole, the cingulum bundle spans the frontal, parietal, and medial temporal areas of the brain, as well as links subcortical nuclei to the cingulate gyrus (Bubb et al, 2018). FA in this prominent white matter tract has been implicated as a factor in ADHD symptom severity, as well as a marker of individual differences in neurocognitive development (Bathelt et al, 2019;Cooper et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…This may be due to differences in DWI analyses, wherein the cingulum is not always delineated in the same way by other tract reconstruction methods. Only some connections encompass the entire length of the tract and different subdivisions of the cingulum display distinct FA measures at different mediallateral positions within the bundle, even in areas of overlap-indicating qualitative changes along the length of the tract (Bubb et al, 2018;Heilbronner and Haber, 2014;. The CAB also consists of projections from the amygdala and thalamic nuclei, and runs close to the inferior longitudinal and uncinate fasciculi.…”

Section: Discussionmentioning

confidence: 99%

White matter microstructure in attention-deficit/hyperactivity disorder: a systematic tractography study in 654 individuals

Damatac

Chauvin

Zwiers

et al. 2019

Preprint

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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by age-inappropriate levels of inattention and/or hyperactivity-impulsivity. ADHD has been related to differences in white matter microstructure, measured by diffusion-weighted imaging (DWI) and quantified by fractional anisotropy (FA). In the largest DWI analysis of ADHD to date, we systematically investigated if FA is associated with: current and lifetime diagnosis, categorical diagnosis and continuous symptom measures, and impairment in daily life.DWI data were obtained from 654 participants (322 unaffected, 258 affected, 74 subthreshold; 7-29 years of age). For each subject, we applied automated global probabilistic tractography with TRACULA on 18 major white matter pathways and linear mixed effects regression models to examine associations with overall brain and tract-specific FA.There was no significant association of FA with current diagnosis or history of ADHD diagnosis, or impairment. Lower FA was significantly associated with higher ADHD symptom severity in the right cingulum's angular bundle (rCAB; P=0.051), and this was mainly driven by hyperactivity-impulsivity symptoms (P=0.033). This is the first time global probabilistic tractography has been applied to an ADHD DWI dataset of this size. Our findings suggest that continuous symptom measures may be more sensitive to FA differences in association with ADHD than diagnostic categories. The rCAB may play an important role in hyperactivity and impulsivity in ADHD.

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“…Noninvasive imaging studies also investigated the role of cingulate regions in executive control, emotion, pain, and episodic memory, and have reported associative abnormalities in memory decline in the MCI and AD pathogenesis (Bubb, Metzler-Baddeley, & Aggleton, 2018). fMRI studies on the cognitive role of CC have shown increased activity in ACC during tasks involving cognitive controls, such as attention, executive functioning and working memory (Lenartowicz & McIntosh, 2005), while the damage of PCC was found to cause trouble with solving cognitive control tasks (Ries et al, 2006).…”

Section: Significance Of Cingulate Region In Cognitive Functioningmentioning

confidence: 99%

Quantitation of in vivo brain glutathione conformers in cingulate cortex among age‐matched control, MCI, and AD patients using MEGA‐PRESS

Shukla

Mandal

Tripathi

et al. 2019

Human Brain Mapping

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Oxidative stress (OS) plays an important role in Alzheimer's disease (AD) and glutathione (GSH) mitigates this effect by maintaining redox‐imbalance and free‐radical neutralization. Quantified brain GSH concentration provides distinct information about OS among age‐matched normal control (NC), mild cognitive impairment (MCI) and AD patients. We report alterations of in vivo GSH conformers, along with the choline, creatine, and N‐acetylaspartate levels in the cingulate cortex (CC) containing anterior (ACC) and posterior (PCC) regions of 64 (27 NC, 19 MCI, and 18 AD) participants using MEscher–GArwood‐Point‐RESolved spectroscopy sequence. Result indicated, tissue corrected GSH depletion in PCC among MCI (p = .001) and AD (p = .028) and in ACC among MCI (p = .194) and AD (p = .025) as compared to NC. Effects of the group, region, and group × region on GSH with age and gender as covariates were analyzed using a generalized linear model with Bonferroni correction for multiple comparisons. A significant effect of group with GSH depletion in AD and MCI was observed as compared to NC. Receiver operator characteristic (ROC) analysis of GSH level in CC differentiated between MCI and NC groups with an accuracy of 82.8% and 73.5% between AD and NC groups. Multivariate ROC analysis for the combined effect of the GSH alteration in both ACC and PCC regions provided improved diagnostic accuracy of 86.6% for NC to MCI conversion and 76.4% for NC to AD conversion. We conclude that only closed GSH conformer depletion in the ACC and PCC regions is critical and constitute a potential biomarker for AD.

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The cingulum bundle: Anatomy, function, and dysfunction

Cited by 540 publications

References 345 publications

Lean mass index is positively associated with white matter volumes in several brain regions in children with overweight/obesity

Lean mass index is positively associated with white matter volumes in several brain regions in children with overweight/obesity

White matter microstructure in attention-deficit/hyperactivity disorder: a systematic tractography study in 654 individuals

Quantitation of in vivo brain glutathione conformers in cingulate cortex among age‐matched control, MCI, and AD patients using MEGA‐PRESS

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