The Cimicifuga racemosa special extract BNO 1055 prevents hot flashes in ovariectomized rats

Kapur, Priya; Wuttke, W.; Seidlová-Wuttke, Dana

doi:10.1016/j.phymed.2010.06.009

Cited by 11 publications

(6 citation statements)

References 28 publications

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“…Polar and unpolar fractions of CR BNO 1055 were subdivided and tested in several animal models. The ovx rat was recently shown to experience regularly occurring temperature pulses as measured by sensitive subcutaneously implanted thermoresistors [65]. A fraction containing primarily actein and deoxyactein proved to ameliorate hot flushes in this animal model as efficiently as E2 ( Figure 5).…”

Section: Active Compounds In Cr Extractsmentioning

confidence: 95%

Plant derived alternatives for hormone replacement therapy (HRT)

Seidlová-Wuttke¹,

Jarry

Wuttke³

2013

Hormone Molecular Biology and Clinical Investigation

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Hormone replacement therapy (HRT) has undisputable positive effects on climacteric complaints, in the bone and on body weight but also several undesired side effects. Therefore, plant-derived alternatives are currently promoted. Phytoestrogens - primarily the isoflavones genistein, daidzein and coumestrol, stemming from soy (Glycine max) or red clover (Trifolium pratense) - were suggested to have the desired but not the undesired effects of estrogens. Most recently published placebo-controlled studies question the beneficial effects. When taken at the time of puberty however, phytoestrogens appear to protect against mammary cancer later in life. Extracts from the rhizome of Cimicifuga racemosa (black cohosh) have no estrogenic effects. In a narrow dose range they have beneficial effects on climacteric complaints, which are due to several compounds with dopaminergic, noradrenergic, serotoninergic and GABAergic actions that act together in the hypothalamus. Ecdysone is produced by several plants, including spinach (Spinacia oleracea) and was very early on shown to increase muscle mass. Later it became apparent that spinach extracts containing ecdysone decreased body fat load, thereby reducing secretion of proinflammatory cytokines by visceral adipocytes and oxidative stress. This had beneficial effects on body weight and serum lipids not only in obese postmenopausal but also in premenopausal women and in men. For the above-described plant extracts, solid placebo-controlled clinical trials are available. For other plant extracts claiming beneficial effects on climacteric complaints or postmenopausal diseases, no solid data are available.

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Section: Active Compounds In Cr Extractsmentioning

confidence: 95%

Plant derived alternatives for hormone replacement therapy (HRT)

Seidlová-Wuttke¹,

Jarry

Wuttke³

2013

Hormone Molecular Biology and Clinical Investigation

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“…Kapur et al [39] have shown that the skin temperature of ovx rats increases at regular intervals ( Fig. 5) and as a result of these pulses the mean skin temperature of ovx rats is significantly higher than in the intact individuals.…”

Section: Efficacy Of Cr In Climacteric Complaintsmentioning

confidence: 88%

“…Very likely the overactive pulse generator produces hot flushes also in ovx rats, similarly as in postmenopausal women. An effect of the aqueous-ethanolic BNO 1055 CR extract and of an isopropanolic CR extract on hot flushes in ovx rats has been demonstrated [39,40]. Ovx rats had a higher skin temperature than animals treated with the BNO 1055 CR extract (Fig.…”

Section: Efficacy Of Cr In Climacteric Complaintsmentioning

confidence: 94%

Black cohosh (Cimicifuga racemosa) is a non-estrogenic alternative to hormone replacement therapy

Wuttke¹,

Seidlová-Wuttke²

2015

Clin Phytosci

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Hormone replacement therapy is still a popular and most effective treatment for vasomotor symptoms and bone loss prevention in the postmenopause but it is not without risks. This has driven many climacteric women to seek for alternatives, chiefly natural products. Phytoestrogens containing soy or red clover preparations, however, when taken at the recommended daily doses, proved to be ineffective to ameliorate climacteric complaints and to prevent osteoporosis. Cimicifuga racemosa (CR) preparations, on the other hand, have been shown to ease climacteric distress. There is a widespread, but false, belief that the efficacy of CR preparations is linked to the presence of phytoestrogens in the plant. This review aims at summarizing the available in vitro and in vivo evidence showing that compounds in CR extracts do not bind to oestrogen receptors and thus do not exert any estrogenic effects in the uterus and mammary gland, as shown in vivo in experiments on ovariectomized rats and clinically in postmenopausal women. Studies in ovariectomized rats and in women suffering from climacteric complaints have indicated that substances with neurotransmitter-like activities affect beneficially postmenopausal symptoms such as hot flushes. Some of these compounds, such as actein-like triterpenes with GABA-ergic activity and a serotonin analogue, are present and have been identified in the CR extracts. We conclude that these activities explain most likely the beneficial effects of CR extracts on climacteric complaints.

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“…Recent randomized controlled studies have shown that CR consumption alleviates "hot flushes," and due to the lack of uterotropic effects, it can be a safe option to estrogen replacement therapy (Racho n et al, 2008). The CR special extract BNO 1055 prevents hot flashes in ovariectomized rats (Kapur et al, 2010). Hot flashes are a disorder of thermoregulation due to the lack of estrogens and are the most common and characteristic climacteric complaint.…”

Section: Effects On Menopausal Symptoms and Femalementioning

confidence: 99%