The "Chubby Puffer" Syndrome

Stool, Sylvan E.; Eavey, Roland D.; Stein, N.; Sharrar, William G.

doi:10.1177/000992287701600108

Cited by 34 publications

(1 citation statement)

References 17 publications

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“…[1][2][3][4][5] Currently, the most frequent indication for T&A is upper airway obstruction due to hypertrophy of the tonsils and adenoids. 5 Chronic upper airway obstruction can lead to obstructive sleep apnea syndrome (OSAS) with chronic alveolar hypoventilation, cor pulmonale, cardiac failure [6][7][8][9][10][11][12][13][14][15] sleep disor-ders, [16][17][18][19] behavioral changes, learning disability, enuresis, and retarded growth. 1,8,14,[20][21][22][23] Published data on the influence of T&A on somatic growth refer to case reports, [24][25][26][27] or include small number of patients, [6][7][8]28 younger than 3 years, primarily affected by OSAS.…”

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confidence: 99%

Improved somatic growth following adenoidectomy and tonsillectomy in young children. Possible pathogenetic mechanisms

Vontetsianos¹,

Davris²,

Christopoulos³

et al. 2005

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The effect of Adenotonsillectomy on somatic growth was studied prospectively in 57, randomly selected children (31 boys, 26 girls), aged 5.03+/-1.32 (mean+/-1SD) years. The indication for surgery was adenotonsillar hypertrophy with or without recurrent infections. Weight, height, triceps skinfold thickness, and Body Mass Index were measured prior to the operation and 6-13 months afterwards. Weight was significantly improved following T&A in all children. The improvement in height was significantly only for children under 5 years. In an attempt to uncover the pathogenetic mechanisms, lactic acid, pyruvic acid, somatomedin-C (IGF-I), growth hormone(GH), insulin, glucose, pH, hemoglobin (Hbeta). and white cell count (WBC) were also determined in the last 18 children, prior to and 6-8 months post operatively. For the comparison of pre and post operative values the paired t test was applied. Although the values of GH and IGF1 did not significantly increase post-op the IGF-1/GH ratio increased, possibly indicating improved IGF1 generation. There was also a rise in Hbeta values and a lowering of WBC, probably reflecting the lower frequency of infections. All other metabolic indices did not change. In conclusion, linear grow post-Adenotonsillectomy improved in children aged <5 years and was associated with improved with IGF-1/GH ratio, increased Hbeta values and decreased in WBC.

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