The chronic kidney disease and acute kidney injury involvement in COVID-19 pandemic: A systematic review and meta-analysis

Liu, Ya Fei; Zhang, Zhe; Pan, Xiao; Xing, Guo; Zhang, Ying; Liu, Zhang Suo; Tu, Sheng Hao

doi:10.1371/journal.pone.0244779

Cited by 49 publications

(40 citation statements)

References 20 publications

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“…In the group of patients with eGFR ≥ 60 mL/min/1.73 m 2 , the rates were 23.25% and 9.64% ( p < 0.001), respectively. Our results are consistent with observations made by other authors [ 18 , 34 , 35 , 36 ]. In a UK population-based cohort study, increased risk of death was evident from eGFR 45–59 mL/min/1.73 m 2 in people with type 1 and type 2 diabetes [ 37 ].…”

Section: Discussionsupporting

confidence: 94%

“…It is believed that there is a correlation between renal function impairment and increased risk of death in patients with COVID-19 [ 20 , 33 , 34 , 35 ]. In this study of nearly 2000 adults with COVID-19, we found that the mortality rate during hospitalization was much higher in patients with eGFR < 60 mL/min/1.73 m 2 than in patients with eGFR ≥ 60 mL/min/1.73 m 2 at admission (29.38% vs. 10.36%, respectively; p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

“…It cannot be ruled out that patients with various levels of kidney function deterioration do not display the same cytokine storm or inflammatory response implicated in diverse clinical manifestations [ 1 ]. Liu et al performed a systematic review and meta-analysis to verify if pre-existing CKD was a risk factor for severe COVID-19 [ 34 ]. According to their findings, there was no significant difference with respect to CKD between the group with critical and severe courses of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

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Kidney Dysfunction and Its Progression in Patients Hospitalized Duo to COVID-19: Contribution to the Clinical Course and Outcomes

Kiliś‐Pstrusińska

Akutko

Braksator

et al. 2021

JCM

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The disease caused by coronavirus SARS-CoV-2 (COVID-19) can affect almost all organs of the human body, including kidneys. We conducted a one-center study to comprehensively analyze the effects of kidney involvement on the course and outcomes in patients hospitalized with COVID-19, depending on the estimated glomerular filtration rate (eGFR) at admission. Out of the 1958 patients, 1342 (68.54%) had eGFR ≥ 60 mL/min/1.73 m2 (group A) and 616 (31.46%) had eGFR < 60 mL/min/1.73 m2 (group B). Group B was additionally divided into subgroups B1, B2, and B3 based on eGFR. We found that mortality rates during hospitalization, as well as after 90 and 180 days, were much higher in group B than group A. The highest mortality was observed in the B2 subgroup with eGFR of 15–29. The mortality of B patients was associated with comorbidities, respiratory dysfunction, immunological impairment, and more frequent development of AKI. AKI had a negative impact on patients’ survival, regardless of the initial renal function. At discharge, 7.4% of patients had serum creatinine levels 30% higher, or more, as compared to admission. The disease course and outcomes in COVID-19 patients are associated with baseline eGFR; however, AKI during hospitalization is a more significant predictor of poor prognosis regardless of the initial renal function.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Kidney Dysfunction and Its Progression in Patients Hospitalized Duo to COVID-19: Contribution to the Clinical Course and Outcomes

Kiliś‐Pstrusińska

Akutko

Braksator

et al. 2021

JCM

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“…Despite the described association between SARS CoV2 and acute renal damage, 37 and although the study cohort included a considerable proportion of patients with CKD, only a very small percentage developed AKI during the first days of hospitalization, concomitant to remdesivir treatment. This aspect deserves particular attention.…”

Section: Discussionmentioning

confidence: 90%

Remdesivir, Renal Function and Short-Term Clinical Outcomes in Elderly COVID-19 Pneumonia Patients: A Single-Centre Study

Biancalana¹,

Chiriacò²,

Sciarrone³

et al. 2021

CIA

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Background Remdesivir, an antiviral agent able to reduce inflammatory cascade accompanying severe, life-threatening pneumonia, became the first drug approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus 2 related severe acute respiratory syndrome (SARS CoV2). As from its previously known clinical indications, the use of remdesivir in the presence of severe renal impairment is contraindicated; however, the impact of remdesivir on renal function in aging patients has not been elucidated. Subjects and Methods This retrospective observational study involved 109 individuals consecutively admitted in internal medicine section, Azienda Ospedaliero Universitaria Pisana hospital, in November–December 2020 due to a confirmed diagnosis of SARS CoV2 and receiving remdesivir according to international inclusion criteria. Biochemical variables at admission were evaluated, together with slopes of estimated glomerular filtration rate (eGFR) built during remdesivir treatment. Participants were followed until discharge or exitus. Results Patients were stratified according to age (80 formed the study cohort and 29 served as controls); CKD stage III was present in 46% of them. No patients showed any sign of deteriorated renal function during remdesivir. Fourteen patients in the elderly cohort deceased; their eGFR at baseline was significantly lower. Recovered patients were characterized by a relevant eGFR gaining during remdesivir treatment. Conclusion We show here for the first time as remdesivir does not influence eGFR in a cohort of elderly people hospitalized for SARS CoV2, and that eGFR gain during such treatment is coupled with a better prognosis.

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“…Of note, LUS score only showed signi cant association with markers of cardiac and renal injury. Patients with COVID-19, especially those with older age included in our cohort [9], are characterized by high comorbidity burden including cardiovascular and renal diseases [19][20][21], which in turn can relate to pulmonary congestion through volume overload.…”

Section: Discussionmentioning

confidence: 99%

Lung Ultrasound in COVID-19: Clinical Correlates and Comparison With Chest Computed Tomography

Portale¹,

Ciolina²,

Arcari³

et al. 2021

Preprint

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Background: lung ultrasound (LUS) and chest computed tomography (chest-CT) are largely employed to evaluate coronavirus-disease-19 (COVID-19) pneumonia. We investigated semi-quantitative LUS and CT scoring in hospitalized COVID-19 patients.Methods: LUS and chest-CT were performed within 24 hours upon admission. Both were analyzed according to semi-quantitative scoring systems. Subgroups were identified according to median LUS score.Results: patients within higher LUS-score group were older (79 vs 60 years, p<0.001), had higher C-reactive protein (CRP) (7.2 vs 1.3 mg/dl, p<0.001) and chest-CT score (10 vs 4, p=0.027) as well as lower PaO2/FiO2 (286 vs 356, p=0.029) as compared to patients within lower scores. We found a significant correlation between scores (r=0.390, p=0.023). Both LUS and CT scores correlated directly with patients age (r=0.586, p<0.001 and r=0.399, p=0.021 respectively) and CRP (r=0.472, p=0.002 and r=0.518, p=0.002 respectively), inversely with PaO2/FiO2 (r=-0.485, p=0.003 and r=-0.440, p=0.017 respectively). LUS-score only showed significant correlation with hs-Troponin T, NT-pro-BNP and creatinine (r=0.433, p=0.019; r=0.411, p=0.027 and r=0.497, p=0.001 respectively).Conclusions: semi-quantitative bedside LUS related to the severity of COVID-19 pneumonia similarly to chest-CT. Correlation of LUS-score with markers of cardiac and renal injury suggests that LUS might contribute to a more comprehensive evaluation of this heterogeneous population.

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The chronic kidney disease and acute kidney injury involvement in COVID-19 pandemic: A systematic review and meta-analysis

Cited by 49 publications

References 20 publications

Kidney Dysfunction and Its Progression in Patients Hospitalized Duo to COVID-19: Contribution to the Clinical Course and Outcomes

Kidney Dysfunction and Its Progression in Patients Hospitalized Duo to COVID-19: Contribution to the Clinical Course and Outcomes

Remdesivir, Renal Function and Short-Term Clinical Outcomes in Elderly COVID-19 Pneumonia Patients: A Single-Centre Study

Lung Ultrasound in COVID-19: Clinical Correlates and Comparison With Chest Computed Tomography

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