The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia.

Abstract

We have examined the chromosomal location of human T cell‐specific genes which are involved in antigen recognition and of a gene which specifically rearranges in T cells. The genes encoding both the variable and constant region segments of the T cell receptor alpha chain are found on chromosome 14 while the delta chain gene of the T cell receptor‐associated T3 complex is localised to chromosome 11. Further, the two tandemly arranged T cell‐specific rearranging genes, designated gamma, were mapped to chromosome 7, but apparently not closely linked to the previously mapped T cell receptor beta‐chain gene. The locations of the three different genes, which undergo rearrangement in T cells, may correlate with the chromosomal breakpoints known to be involved in translocations within abnormal human T cells.

Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells

“…Examples include translocations t(1;14) and t (11;14), involving the genes encoding the TAL1 and LMO1/LMO2 transcription factors, respectively. 25,51 As the breakpoint regions on these chromosomes have been found to be located near RSS or RSS-like sequences, [25][26][27] it is suggestive that accessibility of the involved oncogenes to RAG protein activity might be a critical step in the formation of these chromosome aberrations as well. We therefore also studied TAL1 deletions, which are V(D)J-like rearrangements that are found exclusively in T-ALL, particularly in T-ALL with TCRD deletions.…”

Chromosomal translocation master genes, mouse models and experimental therapeutics

“…The demonstration that rearrangement of genomic fragments of the CMYC oncogene coincide with Ig gene rearrangement clinched this proposal (Dalla-Favera et al, 1982;Taub et al, 1982) and subsequent cloning of translocated CMYC revealed many features of the mechanism and consequences of chromosomal translocations (reviewed in . The association of the rearranging antigen receptor genes with chromosomal translocations in leukaemia was taken further when the T cell receptor (TCR) b chain locus was mapped to chromosome 7, band q35 (Rabbitts et al, 1985), suggesting that chromosomal translocations in T cell tumours are mediated by the intrinsic chromosomal instability of TCR genes, which undergo rearrangement in normal lymphoid lineage development. This was con®rmed by cloning of LMO1 and LMO2 at chromosomal translocation junctions with TCRd and TCRa (Boehm et al, 1988aMcGuire et al, 1989;Royer-Pokora et al, 1991) and of HOX11 and LMO2 at chromosomal translocations with TCRb Dube et al, 1991;Hatano et al, 1991;Kennedy et al, 1991;Lu et al, 1991).…”

High expression of a specific T-cell receptor γ transcript in epithelial cells of the prostate

“…The human TCR␥ locus is located on chromosome 7, p15-p14 (2,3). The TCR␥ gene is composed of variable (V), joining (J), and constant (C) gene segments that undergo a series of rearrangements to form functionally active genes in mature ␥␦ T-lymphocytes.…”