The Chromosomal Complement of Human Solid Tumors

Chromosome studies in 12 solid tumours from children

“…The bodies did not appear to be related to the chromosome set and those cells analysed with the double bodies present had 47 chromosomes and a karyotype indistinguishable from the other modal cells. Their appearance was very similar to the double bodies seen in previously published cases (Lubs and Salmon, 1965;Cox et al, 1965).…”

“…The high proportion of cases in the diploid group, with an apparently normal chromosomal complement in some instances, bears more resemblance to the situation seen in acute leukaemia. Those solid tumours from children analysed in detail by other authors (Lubs and Salmon, 1965;Miles, 1967a) similarly fall into the diploid group and Miles (1967a) recorded an apparently normal diploid karyotype in a neuroblastoma.…”

Chromosome changes in a rhabdomyosarcoma during recurrence and in cell culture.

“…The occurrence of double chromatin bodies in human tumours was first observed by Spriggs, Boddington and Clarke (1962) and reported in more detail by Lubs and Salmon (1965) and Cox et al (1965). In the latter report, 6 tumours were described including recurrence 1 of the present case, in all of which a proportion of the cells observed showed the similar phenomenon of varying numbers of very small double chromatin bodies.…”

A consideration of the aetiology of lip plug carcinoma with special reference to local geographical tumour incidence

“…b;Atkin and Ross, 1960); (3) the finding of the same marker represented twice in the same cell (Miles, 1967a, b; (4) the occasional finding of 4n or near-4n tumours (Miles et al, 1966;Spiers and Baikie, 1968;Lubs and Clark, 1963;Spriggs, Boddington and Clarke, 1962;Lubs and Salmon, 1965;Ricci et al, 1962).…”