The chromogranins A and B: The first 25 years and future perspectives

Abstract

Calcium-binding and aggregation properties of parathyroid secretory protein-1 (chromogranin A). Bone Min. 4, 17-25. GOK S. U., Hamilton J. W. and Cohn D. V. (1991) Sulfated secreted forms of bovine and porcine parathyroid chromogranin A (secretory protein-I). New suggestions for the physiological role of secretory protein-I. Bone Mm. 2, 251-255. Gorr S. U., Shioi J. and Cohn D. V. (1989) Interaction of calcium with porcine adrenal chromogranin A (secretory protein-I) and chromogranin B (secretogranin I). Am. J. Physiol. 257, E247-E254. Gowda D. C., Hogue-Angeletti R., Margolis R. K. and Margolis R. U. (1990) Chromafhn granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A. Archs Biochem. Biophys. Zsl, 219-224. . (1989) Inhibition of glucose-stimulated insulin release in the perfused rat pancreas by parathyroid secretory protein-I (chromogranin-A). Endocrinology 124, 1235-1238. Grimes M., Iacangelo A., Eiden L. E., Godfrey B. and Herbert E. (1987) Chromogranin A: the primary structure deduced from cDNA clones reveals the presence of pairs of basic amino acids. Ann. N. I'. Acad. Sci. 493, 351-378. Grino M., Woblfarter T., Fischer-Colbrie R. and Eiden L. E. (1989) Chromogranin A messenger RNA expression in the rat anterior pituitary is permissively regulated by the adrenal gland . Neuroendocrinology 49, 107-110.

An integrated genomic analysis of gene-function correlation on schizophrenia susceptibility genes

“…21,22 The CHGB gene encodes for chromogranin B, which belongs to a family of soluble proteins stored and released from large dense-core secretory vesicles at the synapse. 36,37 These granins have an important role in the sorting and aggregation of secretory products in the transGolgi network and in the subsequent formation of secretory granules. 38 A reduction of chromogranin B levels in cerebrospinal fluid (CSF), as well as chromogranin B-like immunoreactivity in distinct subregions of the hippocampus were reported in patients with SZ.…”

Chromogranin A: current status as a precursor for bioactive peptides and a granulogenic/sorting factor in the regulated secretory pathway

“…CGA is expressed in a wide variety of neuroendocrine cell types, each of which co-express a unique and cell-specific polypeptide hormone or neurotransmitter ( [1], and references therein). To achieve this co-expression the chromogranin gene must be able to respond to the wide variety of developmental and hormonal signals that drive polypeptide expression in each of these cell types (see Table 1).…”

“…[1]. There are two difficulties in the assumption that CGA, CGB, or SglI need be abundant in all regulated secretory granules in all endocrine cells in order to play a role in granulogenesis in any of them.…”

“…The chromogranin/secretogranin proteins are acidic polypeptides, of apparent molecular mass 70-120 kDa, found ubiquitously in the soluble matrix of dense-core secretory granules in neurons and endocrine cells [1]. The so-called 'granins' include chromogranins A and B and secretogranin II [2].…”

Effects of Acute Prolonged Strenuous Exercise on the Salivary Stress Markers and Inflammatory Cytokines

“…Such studies consistently revealed stress-related downregulation 14) . CgA exists in various endocrine organs and its secretion is regulated by the SAM system 15,16) . In vitro experiments have also demonstrated that CgA exhibits antifungal and antibacterial properties 17,18) .…”