The chromene sargachromanol E inhibits ultraviolet A-induced ageing of skin in human dermal fibroblasts

Abstract

This study suggests that UVA irradiation modulates MMP expression via the transcriptional activation of AP-1 signalling, whereas treatment with sargachromanol E protected cell damage caused by UVA irradiation.

Pretreatment of Ferulic Acid Protects Human Dermal Fibroblasts against Ultraviolet A Irradiation

“…These results suggest the inhibitory effects of ferulic acid against UVA-induced cellular senescence in dermal fibroblasts. Furthermore, UVA has been established as a factor that induces a decrease in type I collagen and inhibition of pro-collagen synthesis in dermal fibroblasts454647. Our results for MMP1 and MMP3 mRNA expression strongly suggest that ferulic acid not only regulates cellular senescence, but also reconstructs the ECM.…”

Photodamage attenuation effect by a tetraprenyltoluquinol chromane meroterpenoid isolated from Sargassum muticum

“…Meroterpenoids from Cystoseira and Sargassum sp. exhibited strong radical scavenging activity, protection against UV-irradiation [5,6], inhibition of lipid peroxidation and O 2 À [28], antifouling [29] and antiinflammatory properties [30].…”

“…This effect was already reported for other algal components which were recognized to have defensive or protective functions against oxidative stress and to exert a ROS scavenging effect [32,33]. Some studies have found that intracellular ROS induced by UVB radiation was reduced by the addition of phlorotannins and cell viability was dose-dependently increased [32], fucoxanthin dose-dependently protected from UVB induced cell injury in human fibroblast [34], chromenes (sargachromanol D, sargachromanol E) suppressed intracellular formation of ROS, membrane protein oxidation, lipid peroxidation and some collagenase MMP expression and improved UV-induced wrinkles without any cytotoxicity and phototoxicity [4][5][6].…”

“…8c1-3). Kim et al [6] reported that sargachromanol E isolated from S. horneri protected cells from damage caused by UVA-irradiation and suppressed morphological changes in dermal fibroblasts in a dose-dependent manner.…”

“…Several secondary metabolites in marine seaweeds offer this potential, including phlorotannins (dieckol, phloroglucinol), scytonemins, carotenoids (astaxanthin, xanthin, fucoxanthin), chromenes (sargachrome, sargachromanol D, sargachromanol E) [4][5][6], mycosporine-like amino acids, plastoquinones (sargaquinoic acid, sargachromenol) [7,3] and meroterpenoids [8].…”