The chromatin remodeling protein BRG1 regulates HSC-myofibroblast differentiation and liver fibrosis

Zhu, Yuwen; Kang, Aoqi; Kuai, Yameng; Guo, Yan; Miao, Xiulian; Zhu, Li; Kong, Ming; Li, Nan

doi:10.1038/s41419-023-06351-5

Cited by 3 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Role Of Smarca4 In Cancer Developmentmentioning

confidence: 99%

“…Moreover, BRG1 has a pivotal role in differentiating myofibroblasts derived from hepatic stellate cells (HSCs) and regulates liver fibrosis. BRG1 is elevated during myofibroblast maturation, while HSC-specific deletion of BRG1 inhibits liver fibrosis [31]. Concerning the role of SMARCA4 in cancer, BRG1 deficiency is implicated in th velopment of several malignancies, such as small-cell carcinoma of the ovary hyperc mic type (SCCOHT), SMARCA4-deficient thoracic sarcoma, colorectal cancer, and e metrial stromal sarcomas [32][33][34][35][36].…”

Section: Role Of Smarca4 In Cancer Developmentmentioning

confidence: 99%

See 1 more Smart Citation

Treatment of Thoracic SMARCA4-Deficient Undifferentiated Tumors: Where We Are and Where We Will Go

Longo,

Catino,

Montrone

et al. 2024

IJMS

View full text Add to dashboard Cite

Recently, the fifth edition of the WHO classification recognized the thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) as a separate entity from conventional non-small cell lung cancer with SMARCA4 deficiency because of the different clinicopathological characteristics of these two diseases. SMARCA4-UT mainly occurs in young to middle-aged adults and involves a large mass compressing the tissues surrounding the mediastinum and lung parenchyma. Unfortunately, SMARCA4-UT shows a high probability of recurrence after upfront surgery as well as radiotherapy resistance; moreover, chemotherapy has low efficacy. Moreover, given the recent classification of SMARCA4-UT, no data concerning specific clinical trials are currently available. However, several case reports show immunotherapy efficacy in patients with this disease not only in a metastatic setting but also in a neoadjuvant manner, supporting the development of clinical trials. In addition, preclinical data and initial clinical experiences suggest that inhibiting pathways such as CDK4/6, AURKA, ATR, and EZH2 may be a promising therapeutic approach to SMARCA4-UT.

show abstract

Section: Role Of Smarca4 In Cancer Developmentmentioning

confidence: 99%

Section: Role Of Smarca4 In Cancer Developmentmentioning

confidence: 99%

Treatment of Thoracic SMARCA4-Deficient Undifferentiated Tumors: Where We Are and Where We Will Go

Longo,

Catino,

Montrone

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Expression of insulin-like growth factor binding protein 5 in the vaginal wall tissues of older women with pelvic organ prolapse

Duan,

Chen,

et al. 2024

Sci Rep

View full text Add to dashboard Cite

This study aimed to investigate the expression and significance of insulin-like growth factor binding protein 5 (IGFBP5) and extracellular matrix (ECM) related proteins in anterior vaginal wall tissues among aged pelvic organ prolapse (POP) patients. Tissues from the anterior vaginal wall were collected from 28 patients with POP and 20 patients without POP. The expression of protein and mRNA levels of IGFBP5 and ECM related proteins were evaluated in the vaginal wall tissues using immunohistochemistry, western blotting, and RT-qPCR techniques. The expression levels were then compared with clinical parameters. The expression levels of protein and mRNA of IGFBP5, collagen I, and collagen III were significantly lower in the POP group. Protein and mRNA expression levels of MMP2 were significantly higher in the POP group. IGFBP5 protein and mRNA expression levels were negatively correlated with age and significantly lower in older POP patients (≥ 65 years old) compared to younger POP patients (< 65 years old). IGFBP5 protein and mRNA expression levels were also significantly lower in POP-Q stage IV patients compared to POP-Q stage III patients. IGFBP5 expression level is negatively correlated with the age and severity of prolapse. The significant decrease in IGFBP5 expression may play a crucial part in the aging process and the occurrence of POP.

show abstract

GSK805 inhibits alpha‐smooth muscle expression and modulates liver inflammation without impairing the well‐being of mice

Nierath,

Leitner,

Reimann

et al. 2024

The FASEB Journal

View full text Add to dashboard Cite

Cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), lead to inflammation and severe hepatic damage with limited therapeutic options. This study assessed the efficacy of the inverse RORγt agonist, GSK805, both in vitro using the hepatic stellate cell‐line LX‐2 and in vivo using male bile duct‐ligated BALB/c mice. In vitro, 0.3 μM GSK805 reduced alpha‐smooth muscle actin expression in LX‐2 cells. In vivo, GSK805 significantly decreased IL‐23R, TNF‐α, and IFN‐γ expression in cholestatic liver. Despite high concentrations of GSK805 in the liver, no significant reduction in fibrosis was noticed. GSK805 significantly increased aspartate aminotransferase and alanine aminotransferase activity in the blood, while levels of glutamate dehydrogenase, alkaline phosphatase, and bilirubin were not substantially increased. Importantly, GSK805 did neither increase an animal distress score nor substantially reduce body weight, burrowing activity, or nesting behavior. These results suggest that a high liver concentration of GSK805 is achieved by daily oral administration and that this drug modulates inflammation in cholestatic mice without impairing animal well‐being.

show abstract

The chromatin remodeling protein BRG1 regulates HSC-myofibroblast differentiation and liver fibrosis

Cited by 3 publications

References 37 publications

Treatment of Thoracic SMARCA4-Deficient Undifferentiated Tumors: Where We Are and Where We Will Go

Treatment of Thoracic SMARCA4-Deficient Undifferentiated Tumors: Where We Are and Where We Will Go

Expression of insulin-like growth factor binding protein 5 in the vaginal wall tissues of older women with pelvic organ prolapse

GSK805 inhibits alpha‐smooth muscle expression and modulates liver inflammation without impairing the well‐being of mice

Contact Info

Product

Resources

About