The chromatin factor Gon4l regulates embryonic axis extension by promoting mediolateral cell polarity and notochord boundary formation through negative regulation of cell adhesion

Abstract

Anteroposterior axis extension during vertebrate gastrulation requires cell proliferation, embryonic 13 patterning, and morphogenesis to be spatiotemporally coordinated, but the underlying genetic 14 mechanisms remain poorly understood. Here we define a role for the conserved chromatin factor Gastrulation is a critical period of animal development during which the three primordial germ layers -28 ectoderm, mesoderm, and endoderm -are specified, patterned, and shaped into a rudimentary body plan.