The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level

Chen, M. P.; Yang, Shu Hua; Chou, Chih-Hsing; Yang, Kai Chiang; Wu, Chang Chin; Cheng, Yu-Chieh; Lin, Feng Huei

doi:10.1007/s00011-010-0165-9

Cited by 62 publications

(34 citation statements)

References 38 publications

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“…Thus, the levels of TNF- α and IL-1 β in plasma may reflect the activity of inflammatory cells [25]. A previous report has indicated that FA had the ability to decrease the levels of hydrogen peroxide-induced IL-1 β , TNF- α , MMP-1, and MMP-13, thereby reducing bone destruction [26], synovitis, and the erosion of cartilage in antigen-induced arthritis [27]. Because of their purported protective effects on joints, FA and OD (which contains FA) were administered to CIA rats, and, as shown in Figures 4–10, the animals' symptoms ware ameliorated, the number of inflammatory cells decreased, and the levels of IL-1 β and TNF- α declined by day 28 and day 42.…”

Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen‐Induced Arthritis in Rats

Zhu

Xiong

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Objectives. This study aimed to identify the active compounds in Oldenlandia diffusa (OD) decoction and the compounds absorbed into plasma, and to determine whether the absorbed compounds derived from OD exerted any anti-inflammatory effects in rats with collagen induced arthritis (CIA). Methods. The UPLC-PDA (Ultra Performance Liquid Chromatography Photo-Diode Array) method was applied to identify the active compounds both in the decoction and rat plasma. The absorbable compound was administered to the CIA rats, and the effects were dynamically observed. X-ray films of the joints and HE stain of synovial tissues were analyzed. The levels of IL-1β and TNF-α in the rats from each group were measured by means of ELISA. The absorbed compound in the plasma of CIA rats was identified as ferulic acid (FA), following OD decoction administration. Two weeks after the administration of FA solution or OD decoction, the general conditions improved compared to the model group. The anti-inflammatory effect of FA was inferior to that of the OD decoction (P < 0.05), based on a comparison of IL-1β TNF-α levels. FA from the OD decoction was absorbed into the body of CIA rats, where it elicited anti-inflammatory responses in rats with CIA. Conclusions. These results suggest that FA is the bioactive compound in OD decoction, and FA exerts its effects through anti-inflammatory pathways.

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Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen‐Induced Arthritis in Rats

Zhu

Xiong

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Furthermore, NO can inhibit the synthesis of collagens and proteoglycans and can increase MMP activity in chondrocytes [24]. Pathologic changes include the decreased synthesis of ECM proteins, and the local accumulation of destructive enzymes was observed in H 2 O 2 -stimulated chondrocytes [25]. Drugs for the treatment of degenerative diseases of articular joints may be developed by increasing the synthesis of ECM molecules such as type II collagen and SOX9 and by inhibiting destructive enzymes such as MMPs [26].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Ginsenoside Rb₁on Hydrogen Peroxide-induced Oxidative Stress in Rat Articular Chondrocytes

Kim¹,

Na²,

Song³

et al. 2012

Journal of Ginseng Research

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The abnormal maturation and ossification of articular chondrocytes play a central role in the pathogenesis of osteoarthritis (OA). Inhibiting the enzymatic degradation of the extracellular matrix and maintaining the cellular phenotype are two of the major goals of interest in managing OA. Ginseng is frequently taken orally, as a crude substance, as a traditional medicine in Asian countries. Ginsenoside Rb1, a major component of ginseng that contains an aglycone with a dammarane skeleton, has been reported to exhibit various biological activities, including anti-inflammatory and anti-tumor effects. However, a chondroprotective effect of ginsenoside Rb1 related to OA has not yet been reported. The purpose of this study was to demonstrate the chondroprotective effect of ginsenoside Rb1 on the regulation of pro-inflammatory factors and chondrogenic genes. Cultured rat articular chondrocytes were treated with 100 μM ginsenoside Rb1 and/or 500 μM hydrogen peroxide (H2O2) and assessed for viability, reactive oxygen species production, nitric oxide (NO) release, and chondrogenic gene expression. Ginsenoside Rb1 treatment resulted in reductions in the levels of pro-inflammatory cytokine and NO in H2O2-treated chondrocytes. The expression levels of chondrogenic genes, such as type II collagen and SOX9, were increased in the presence of ginsenoside Rb1, whereas the expression levels of inflammatory genes related to chondrocytes, such as MMP1 and MMP13, were reduced by approximately 50%. These results suggest that ginsenoside Rb1 has potential for use as a therapeutic agent in OA patients.

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“…It has been reported to have anti-inflammation, antiapoptosis, anticancer, and antiaging properties [105, 106]. FA suppressed ROS accumulation in cultured rabbit NP cells and consequently retarded apoptosis.…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

Feng

Yang

Lan

et al. 2017

Oxidative Medicine and Cellular Longevity

279

262

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Excessive reactive oxygen species (ROS) generation in degenerative intervertebral disc (IVD) indicates the contribution of oxidative stress to IVD degeneration (IDD), giving a novel insight into the pathogenesis of IDD. ROS are crucial intermediators in the signaling network of disc cells. They regulate the matrix metabolism, proinflammatory phenotype, apoptosis, autophagy, and senescence of disc cells. Oxidative stress not only reinforces matrix degradation and inflammation, but also promotes the decrease in the number of viable and functional cells in the microenvironment of IVDs. Moreover, ROS modify matrix proteins in IVDs to cause oxidative damage of disc extracellular matrix, impairing the mechanical function of IVDs. Consequently, the progression of IDD is accelerated. Therefore, a therapeutic strategy targeting oxidative stress would provide a novel perspective for IDD treatment. Various antioxidants have been proposed as effective drugs for IDD treatment. Antioxidant supplementation suppresses ROS production in disc cells to promote the matrix synthesis of disc cells and to prevent disc cells from death and senescence in vitro. However, there is not enough in vivo evidence to support the efficiency of antioxidant supplementation to retard the process of IDD. Further investigations based on in vivo and clinical studies will be required to develop effective antioxidative therapies for IDD.

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The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level

Abstract: FA decreased the hydrogen peroxide-induced IL-1beta, TNF-alpha, MMP-1 and MMP-13 and increased SOX9 gene expression. These findings suggest that FA may prove to be important in the treatment of osteoarthritis. Further research is needed.

Cited by 62 publications

References 38 publications

Anti‐Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen‐Induced Arthritis in Rats

Anti‐Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen‐Induced Arthritis in Rats

Protective Effect of Ginsenoside Rb₁on Hydrogen Peroxide-induced Oxidative Stress in Rat Articular Chondrocytes

ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

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The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level

Abstract: FA decreased the hydrogen peroxide-induced IL-1beta, TNF-alpha, MMP-1 and MMP-13 and increased SOX9 gene expression. These findings suggest that FA may prove to be important in the treatment of osteoarthritis. Further research is needed.

Cited by 62 publications

References 38 publications

Anti‐Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen‐Induced Arthritis in Rats

Anti‐Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen‐Induced Arthritis in Rats

Protective Effect of Ginsenoside Rb1on Hydrogen Peroxide-induced Oxidative Stress in Rat Articular Chondrocytes

ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

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Protective Effect of Ginsenoside Rb₁on Hydrogen Peroxide-induced Oxidative Stress in Rat Articular Chondrocytes