The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study

Isaacs, Aaron; Sayed‐Tabatabaei, Fakhredin A.; Hofman, Albert; Oostra, Ben A.; Klungel, Olaf H.; Zee, Anke-Hilse Maitland-vander; Stricker, Bruno H. Ch.; Witteman, Jacqueline C. M.; Duijn, Cornelia M. van

doi:10.1097/hjr.0b013e32801101aa

Cited by 18 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As published previously, baseline characteristics did not differ between genotypes with respect to the CETP I405V polymorphism (20). Similarly, no differences for these traits were observed by LIPC genotype, with the exception of systolic blood pressure.…”

Section: Resultssupporting

confidence: 83%

“…Of these, some found no effect (17,18), and another observed no differences in allele frequencies between children of early MI patients and controls (19). The CETP I405V polymorphism was previously studied in the Rotterdam Study and was associated with an 0.06 mmol/liter increase in HDL-c levels in both men and women and a significant decrease in MI risk in males (20).…”

Section: Espite Considerable Progress In the Preventionmentioning

confidence: 99%

See 1 more Smart Citation

Epistatic Effect of Cholesteryl Ester Transfer Protein and Hepatic Lipase on Serum High-Density Lipoprotein Cholesterol Levels

Isaacs¹,

Aulchenko²,

Hofman³

et al. 2007

The Journal of Clinical Endocrinology & Metabolism

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 83%

Section: Espite Considerable Progress In the Preventionmentioning

confidence: 99%

Epistatic Effect of Cholesteryl Ester Transfer Protein and Hepatic Lipase on Serum High-Density Lipoprotein Cholesterol Levels

Isaacs¹,

Aulchenko²,

Hofman³

et al. 2007

The Journal of Clinical Endocrinology & Metabolism

Self Cite

View full text Add to dashboard Cite

show abstract

“…There have been conflicting results on the role of genetic variants of CETP and APOAI in modulating statin response (Isaacs et al, 2007). CETP 405I allele was shown to be associated with higher TG reduction and HDL-C elevation in response to simvastatin (Table 4) (Anagnostopoulou et al, 2007); however, this was not replicated in our study.…”

contrasting

confidence: 75%

Common Variants ofHMGCR, CETP, APOAI, ABCB1, CYP3A4, andCYP7A1Genes as Predictors of Lipid-Lowering Response to Atorvastatin Therapy

Poduri

Khullar

Bahl

et al. 2010

DNA and Cell Biology

View full text Add to dashboard Cite

There is interindividual variation in lipid-lowering response to statins. The objective of this study was to investigate whether common variation in genes involved in lipid and statin metabolism modify the effect of statins on serum total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol concentration in coronary artery disease (CAD) patients. We studied the association between 18 single-nucleotide polymorphisms (SNPs) in six genes (HMGCR, CETP, APOAI, ABCB1, CYP3A4, CYP7A1) in response to atorvastatin therapy (20 mg/day) in 265 newly diagnosed CAD patients using multivariable adjusted general linear regression. Variant alleles of ABCB1 (-41A/G), HMGCR SNP29 G/T, rs5908A/G, rs12916C/T, and CYP7A1-204A/C polymorphisms were significantly associated with attenuated LDL-C reduction and variant alleles of CETP TaqI, -629C/A, and APOAI PstI polymorphisms were associated with higher increase in high-density lipoprotein-cholesterol. A three-loci interaction model consisting of CYP7A1rs892871AA/APOAIPstIP1P1/HMGCR rs12916CT was a better predictor for LDL-C lowering, when compared with single polymorphisms analysis on statin response. Variant genotypes of APOAI -2500C/T, CETP 405I/V, and ABCB1 3435C/T showed higher risk of myocardial infarction events (p < 0.05) in a 1-year follow-up of CAD patients. These results suggest that SNPs in lipid and statin pathway genes are associated with reduced LDL-C lowering by statins and identify individuals who may be resistant to maximal LDL-C lowering by statins.

show abstract

“…rs6897932 genotyping was performed as previously described with either a Sequenom platform (16) or TaqMan assay (17). Both MS patients (p = 0.98) and HC (p = 0.89) were in Hardy-Weinberg equilibrium.…”

Section: Genotypingmentioning

confidence: 99%

The IL-7Rα Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis

Kreft

Verbraak

Wierenga‐Wolf

et al. 2012

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

The IL-7Rα single nucleotide polymorphism rs6897932 is associated with an increased risk for multiple sclerosis (MS). IL-7Rα is a promising candidate to be involved in autoimmunity, because it regulates T cell homeostasis, proliferation, and antiapoptotic signaling. However, the exact underlying mechanisms in the pathogenesis of MS are poorly understood. We investigated whether CD4 and CD8 lymphocyte subsets differed in IL-7Rα expression and functionality in 78 MS patients compared with 59 healthy controls (HC). A significantly higher frequency of IL-7Rα+ CD8 effector memory (CD8EM) was found in MS. Moreover, IL-7Rα membrane expression was significantly increased in MS in naive and memory CD8 (all p < 0.05) with a similar trend in CD8EM (p = 0.055). No correlation was found between the expression level or frequency of IL-7Rα+CD8+ and rs6897932 risk allele carriership. Upon IL-7 stimulation, MS patients had stronger STAT5 activation in CD8EM compared with HC. IL-7 stimulation had a differential effect on both mRNA and protein expression of granzyme A and granzyme B between MS and HC. Stainings of different lesions in postmortem MS brain material showed expression of IL-7 and CD8+IL-7Rα+ in preactive, but not in active, demyelinating MS lesions, indicating involvement of IL-7Rα+ lymphocytes in lesion development. The intralesional production of IL-7 in combination with the lower threshold for IL-7–induced cytotoxicity in MS may enhance the pathogenicity of these CD8 T cells. This is of special interest in light of the established demyelinating and cytotoxic actions of granzyme A.

show abstract

The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study

Abstract: This study provides additional evidence for the association of CETP with HDL levels and suggests that CETP is an atherogenic protein increasing the risk of MI.

Cited by 18 publications

References 10 publications

Epistatic Effect of Cholesteryl Ester Transfer Protein and Hepatic Lipase on Serum High-Density Lipoprotein Cholesterol Levels

Epistatic Effect of Cholesteryl Ester Transfer Protein and Hepatic Lipase on Serum High-Density Lipoprotein Cholesterol Levels

Common Variants ofHMGCR, CETP, APOAI, ABCB1, CYP3A4, andCYP7A1Genes as Predictors of Lipid-Lowering Response to Atorvastatin Therapy

The IL-7Rα Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis

Contact Info

Product

Resources

About