The Choice of Treatment Based on Turkish Hypertension Consensus Report: Do We Follow The Recommendations?

Yürüyen, Gülden; Toprak, İlkim Deniz; Toprak, Zeki; Akarsu, Murat; Demir, Pınar; Arman, Yücel; Çil, Eylem Özgün; Özcan, Mustafa; Irmak, Sedat; Altun, Özgür; Yoldemir, Şengül Aydin; Eruzun, Hasan; Tükek, Tufan

doi:10.5543/tkda.2017.86344

Cited by 2 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, unlike the guidelines according to the ATC-2 subclassification, diuretics were the fourth chosen drug whereas according to the ATC-5 subclassification a high-ceiling diuretic, furosemide was the third-chosen drug in hypertension treatment. In a study conducted in Turkey and in Nigeria, diuretics was the most preferred drugs [15,16]. In this study, it was observed that the most common prescribed diuretics were the highceiling diuretics and potassium-sparing agents.…”

Section: Pharmacotherapy Of Hypertension In North Cyprus фармакотерапmentioning

confidence: 75%

“…В дополнение к этому, в отличие от рекомендаций по подклассу АТХ-2, диуретики являлись четвертыми по частоте назначения; по подклассу АТХ-5 петлевой диуретик фуросемид был третьим по назначаемости препаратом при АГ. По данным исследований, проведенных в Турции и Нигерии, диуретики являлись наиболее предпочтительными средствами [15,16]. Настоящее исследование выявило, что назначенные диуретики в основном относились к группам петлевых и калийсберегающих, и такие результаты позволили предположить, что врачи избегают применять диуретики в качестве препаратов выбора из-за их побочного действия в виде гипокалиемии.…”

Section: Discussionunclassified

“…In this group 44.4% of the drugs belonged to the ACE-inhibitors whereas 55.6% of them belonged to the angiotensin receptor blockers (ARB). Turkish Hypertension Consensus does not distinguish ACE inhibitors from the ARBs [16]. Therefore, this could be the reason to have a tendency to prescribe an ARB, even though ACE inhibitors are more affordable.…”

Section: Pharmacotherapy Of Hypertension In North Cyprus фармакотерапmentioning

confidence: 99%

“…В этой группе 44,4% препаратов относились к ингибиторам АПФ, в то время как 55,6% являлись блокаторами рецепторов ангиотензина (БРА). Турецкий Консенсус по лечению гипертонии не выделяет ингибиторы АПФ отдельно от БРА [16], следовательно, это может служить причиной частого назначения БРА, хотя ингибиторы АПФ более доступны по цене. В отличие от нашего исследования, БРА были самыми редко назначаемыми препаратами по данным исследований, проведенных в Нигерии и Бахрейне [12,15], это может быть следствием высокой стоимости современных БРА.…”

Section: Pharmacotherapy Of Hypertension In North Cyprus фармакотерапunclassified

“…Например, ингибиторы АПФ рекомендованы для лечения пациентов с АГ, имеющих в анамнезе инфаркт миокарда и хроническую сердечную недостаточность, БРА рекомендованы в случае плохой переносимости ингибиторов АПФ [5,6]. В то же время положения Турецкого Консенсуса по гипертензии рекомендуют использование ингибиторов АПФ или БРА в качестве препаратов выбора у пациентов с сахарным диабетом и избегают использования диуретиков, которые противопоказаны [16]. Кроме того, в одном исследовании был заявлен ренопротективный эффект регулярного лечения ингибиторами АПФ или БРА [20].…”

Section: Pharmacotherapy Of Hypertension In North Cyprus фармакотерапunclassified

See 4 more Smart Citations

Antihypertensive Drug Utilization in Two Districts of Northern Cyprus

Tamirci

Demirdamar

2019

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

Aim. Since the irrational use of medicine increases the risk of morbidity and mortality in hypertension, this study was aimed to evaluate antihypertensive pharmacotherapy at two districts of Northern Cyprus (NC).Material and methods. A total of 148 prescriptions including antihypertensive drugs (n=181) were obtained by the aid of five pharmacists between November 2017 August 2018 and evaluated regarding the antihypertensive drug choices and good prescribing principles. The prescribed antihypertensive agents were classified according to the Anatomical Therapeutic Chemical Classification System (ATC) 2, 3 and 5 and the prescriptions were evaluated regarding the availability of format information.Results. The mean of antihypertensive agents per prescription was 1.2±0.6. According to the ATC-3 subclassification, beta-blockers (22.1%), angiotensin receptor blockers (ARBs) (22.1%), calcium channel blockers (20.4%), angiotensin converting enzyme inhibitor (ACE) inhibitors (17.7%), diuretics (13.8%) and anti-adrenergic drugs (3.9%) were prescribed. According to the ATC-5 subclassification, the most common prescribed antihypertensives were metoprolol (16.6%), amlodipine (16.0%), furosemide (8.8%), captopril (7.7%) and losartan (6.6%). There were no significant relation between the prescribed antihypertensive agents and gender and the physicians serving either in governmental or private hospitals. There were shortcomings in the prescriptions such as age, diagnosis and drug information which were crucial for the chosen of an appropriate antihypertensive agent.Conclusion. This first pharmacoepidemiological study about antihypertensive drug utilization in NC indicates the imperfections of physicians in terms of prescribing antihypertensive agents according to the guidelines and writing a “legible and good” prescription that contains full information. These findings underline necessity of educational interventions for physicians to disseminate rational use of medicine (RUM) in the NC.

show abstract

Section: Pharmacotherapy Of Hypertension In North Cyprus фармакотерапmentioning

confidence: 75%

Section: Discussionunclassified

Section: Pharmacotherapy Of Hypertension In North Cyprus фармакотерапmentioning

confidence: 99%

Section: Pharmacotherapy Of Hypertension In North Cyprus фармакотерапunclassified

See 3 more Smart Citations

Antihypertensive Drug Utilization in Two Districts of Northern Cyprus

Tamirci

Demirdamar

2019

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

show abstract

Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017

Şahin

Gökalp

Hocaoğlu

et al. 2021

Journal of Basic and Clinical Health Sciences

View full text Add to dashboard Cite

The purpose of our study is to reveal the demographic features, exposure routes and reasons for exposure, clinical effects and outcomes of cardiovascular drug poisonings reported to the Dokuz Eylul University Drug and Poison Information Center (DEUDPIC) between January 2014 and December 2017. Methods: This retrospective, descriptive, and cross-sectional study was approved by the Noninvasive Research Ethics Committee of Dokuz Eylül University School of Medicine. All data were recorded on standard data forms and then transferred to a software (Ruber, written by Engin Yildiztepe, 2007) for data analysis. Results: There were 43 poisonings cases were reported with cardiovascular drugs. Female cases were common (60.47%). Half of the poisoning cases were toxic (51.16%). The most common reason of poisonings was intentional (81.40%). All of cases between 13-49 age group were intentional exposures. Only single substance intakes were responsible for the most of the drug exposures (62.79%). The most common agents were beta-blockers (29.85%), medicines that affect the renin-angiotensin system (23.88 %), calcium channel blockers (11.94%) and cardiac therapy drugs such as digoxin (11.94%). Clinical signs and symptoms were classified as asymptomatic (37.21%), mild (23.26%), moderate (23.26%), and severe (4.65%). Recommended treatments were observation and supportive care (46.67%), decontamination methods (44.00%) and antidote therapy (2.67%). One fatality was reported. Conclusions: We suggest that determination of the epidemiological characteristics of cardiovascular drug exposures in our country through prospectively multi-centered studies may provide significant contributions to prevent poisonings and decrease the mortality and morbidity of the cases.

show abstract

The Choice of Treatment Based on Turkish Hypertension Consensus Report: Do We Follow The Recommendations?

Abstract: Antihypertensive therapies were individualized, as suggested by the consensus report. However, there are proposals still to be considered in special patient groups.

Cited by 2 publications

References 0 publications

Antihypertensive Drug Utilization in Two Districts of Northern Cyprus

Antihypertensive Drug Utilization in Two Districts of Northern Cyprus

Evaluation of Cardiovascular Drug Poisonings Reported to the Dokuz Eylul University Drug and Poison Information Center Between 2014 and 2017

Contact Info

Product

Resources

About