The Choice of the Treatment Method for Cerebral Aneurysms of Different Locations in the Era of Advanced Endovascular Technologies: A Meta-Analysis

Бывальцев, В. А.; Анатольевич, Бывальцев Вадим; Belykh, Evgenii; Георгиевич, Белых Евгений; Stepanov, I. A.; Андреевич, Степанов Иван

doi:10.15690/vramn615

Cited by 2 publications

(1 citation statement)

References 24 publications

(32 reference statements)

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“…One of the most serious complications of the EC-IC bypass operations is cerebral ischemia associated with vascular thrombosis. The frequency of thrombosis has been reported to be as low as 1.7% in specialized centers [ 59 ]. The presence of thrombosis cannot be estimated on a nonliving model; therefore laboratory animal models give the opportunity to identify and analyze the causes of errors and develop methods to prevent their further occurrence.…”

Section: “Wet” Training Using Live Modelsmentioning

confidence: 99%

Microvascular Anastomosis Training in Neurosurgery: A Review

Byvaltsev

Akshulakov²,

Polkin

et al. 2018

Minimally Invasive Surgery

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Cerebrovascular diseases are among the most widespread diseases in the world, which largely determine the structure of morbidity and mortality rates. Microvascular anastomosis techniques are important for revascularization surgeries on brachiocephalic and carotid arteries and complex cerebral aneurysms and even during resection of brain tumors that obstruct major cerebral arteries. Training in microvascular surgery became even more difficult with less case exposure and growth of the use of endovascular techniques. In this text we will briefly discuss the history of microvascular surgery, review current literature on simulation models with the emphasis on their merits and shortcomings, and describe the views and opinions on the future of the microvascular training in neurosurgery. In “dry” microsurgical training, various models created from artificial materials that simulate biological tissues are used. The next stage in training more experienced surgeons is to work with nonliving tissue models. Microvascular training using live models is considered to be the most relevant due to presence of the blood flow. Training on laboratory animals has high indicators of face and constructive validity. One of the future directions in the development of microsurgical techniques is the use of robotic systems. Robotic systems may play a role in teaching future generations of microsurgeons. Modern technologies allow access to highly accurate learning environments that are extremely similar to real environment. Additionally, assessment of microsurgical skills should become a fundamental part of the current evaluation of competence within a microneurosurgical training program. Such an assessment tool could be utilized to ensure a constant level of surgical competence within the recertification process. It is important that this evaluation be based on validated models.

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Section: “Wet” Training Using Live Modelsmentioning

confidence: 99%

Microvascular Anastomosis Training in Neurosurgery: A Review

Byvaltsev

Akshulakov²,

Polkin

et al. 2018

Minimally Invasive Surgery

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Role of inflammation cytokines in forming and rupture of brain arterio-venous malformations

Бывальцев¹,

Stepanov²,

Тетюшкин³

et al. 2018

ZHurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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Представлен обзор современных данных литературы по изучению роли различных цитокинов воспаления в патогенезе формирования и разрыва церебральных артериовенозных мальформаций (цАВМ). Разрыв цАВМ с формированием внутричерепного кровоизлияния - это наиболее частое и грозное клиническое проявление, приводящее к развитию стойкого неврологического дефицита, ранней инвалидизации и летальным исходам. В патогенезе развития цАВМ важнейшую роль играет воспалительный процесс, приводящий к истончению сосудистой стенки. Обнаружена зависимость между некоторыми генетическими полиморфизмами, которые усиливают экспрессию ряда ангиогенных и провоспалительных факторов, играющих ключевую роль в патогенезе разрыва цАВМ. Представлен анализ экспериментальных исследований, проводимых в мире, по влиянию генетических факторов и провоспалительных цитокинов на развитие, прогрессирование и разрыв цАВМ. Приведены современные данные о молекулярных терапевтических подходах к лечению цАВМ. Обозначены актуальные, остающиеся нерешенными вопросы, что обусловливает необходимость проведения дальнейших экспериментальных и клинических исследований при лечении данной нозологической формы. This review analyzes current reports on the pathogenetic role of inflammatory cytokines in formation and rupture of cerebral arteriovenous malformations (cAVM). The authors analyzed reports from PubMed, MedLine, and eLibrary databases that addressed the role of inflammatory cytokines in the molecular pathogenesis of cAVM formation and rupture. The cAVM rupture leading to intracranial hemorrhage is the most frequent and formidable clinical manifestation resulting in persistent neurologic deficits, early disability, and death. In the pathogenesis of cAVM development, an important role belongs to the inflammatory process, which induces thinning of the vascular wall. Relationships were found between some genetic polymorphisms that enhance expression of a number of angiogenic and proinflammatory factors that play a key role in the pathogenesis of cAVM rupture. The review presents experimental studies conducted worldwide and focusing on the influence of genetic factors and proinflammatory cytokines on cAVM development, progression and rupture. The authors provided modern molecular therapeutic approaches to the treatment of cAVM. The topical, still unsolved issues were identified, which warrant further experimental and clinical studies on the treatment of this nosological form.

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The Choice of the Treatment Method for Cerebral Aneurysms of Different Locations in the Era of Advanced Endovascular Technologies: A Meta-Analysis

Cited by 2 publications

References 24 publications

Microvascular Anastomosis Training in Neurosurgery: A Review

Microvascular Anastomosis Training in Neurosurgery: A Review

Role of inflammation cytokines in forming and rupture of brain arterio-venous malformations

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