The Choice of a Suture to Close Abdominal Incisions

Bucknall, T E; Teare, L.; Ellis, Harold

doi:10.1159/000128334

Cited by 68 publications

(31 citation statements)

References 7 publications

(7 reference statements)

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“…This relationship is frequently not addressed in the relative comparison between different suture types in vivo. Several studies have shown black braided silk to elicit a greater FBR when compared to other commonly used sutures [43][44][45]. However, a single fiber of native silk is composed of several individual fibroin filaments and a single black braided suture comprises several extracted silk fibers.…”

Section: Foreign Body Response To Silkmentioning

confidence: 99%

“…A curiosity about the study was the choice to close all the wounds of all study groups with silk suture, potentially sensitizing the animals to the silk suture under investigation. Bucknall et al [45] examined four sutures in abdominal wound closure in a rat model 10, 30, and 70 days postimplantation. Histological examination revealed silk elicited a 'moderate' zone of inflammation compared to a 'minimal response' induced by multi-and monofilament nylon and multifilament PGA (Table 3).…”

Section: Concernsmentioning

confidence: 99%

“…In a rat model with subcutaneous implantation, silk fibers lost 29% of their tensile strength at 10 days, 73% at 30 days and 83% 70 days post-implantation (Table 7) [45]. In abdominal wound closures in the rat, silk promoted a moderate foreign body response compared to mono-and multifilament nylon and polyglycolic acid (PGA) sutures [45].…”

Section: Silk Degradationmentioning

confidence: 99%

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Silk-based biomaterials

et al. 2003

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Silk from the silkworm, Bombyx mori, has been used as biomedical suture material for centuries. The unique mechanical properties of these fibers provided important clinical repair options for many applications. During the past 20 years, some biocompatibility problems have been reported for silkworm silk; however, contamination from residual sericin (glue-like proteins) was the likely cause. More recent studies with well-defined silkworm silk fibers and films suggest that the core silk fibroin fibers exhibit comparable biocompatibility in vitro and in vivo with other commonly used biomaterials such as polylactic acid and collagen. Furthermore, the unique mechanical properties of the silk fibers, the diversity of side chain chemistries for 'decoration' with growth and adhesion factors, and the ability to genetically tailor the protein provide additional rationale for the exploration of this family of fibrous proteins for biomaterial applications. For example, in designing scaffolds for tissue engineering these properties are particularly relevant and recent results with bone and ligament formation in vitro support the potential role for this biomaterial in future applications. To date, studies with silks to address biomaterial and matrix scaffold needs have focused on silkworm silk. With the diversity of silk-like fibrous proteins from spiders and insects, a range of native or bioengineered variants can be expected for application to a diverse set of clinical needs. r

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Section: Foreign Body Response To Silkmentioning

confidence: 99%

Section: Concernsmentioning

confidence: 99%

Section: Silk Degradationmentioning

confidence: 99%

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Silk-based biomaterials

et al. 2003

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“…We also observed areas of squamous metaplasia in the cervices of the Mersilene and Vicryl suture control animals, which was not seen with silk gel. It is known that Vicryl promotes a mild inflammatory response in the rat abdomen 35 and squamous metaplasia is a response to chronic inflammation. 36,37 We speculate that areas of squamous metaplasia may represent increased inflammatory responses to cervical sutures compared with the silk gel.…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility of a Sonicated Silk Gel for Cervical Injection During Pregnancy: In Vivo and In Vitro Study

et al. 2014

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Objective: To evaluate the biocompatibility of silk gel for cervical injection. Study Design: Silk gel was injected into the cervix of pregnant rats on day 13 (n ¼ 11) and harvested at day 17. Histology of silk gel was compared with suture controls. Also, human cervical fibroblasts were cultured on silk gel and tissue culture plastic (TCP) in vitro. Cell viability, proliferation, metabolic activity, gene expression (COL1A1, COL3A1, and COX2), and release of proinflammatory mediators (interleukin [IL] 6 and IL-8) were evaluated. Results: In vivo, a mild foreign body response was seen surrounding the silk gel and suture controls. In vitro, cervical fibroblasts were viable, metabolically active, and proliferating at 72 hours. Release of IL-6 and IL-8 was similar on silk gel and TCP. Collagen and COX2 gene expression was similar or slightly decreased compared with TCP. Conclusions: Silk gel was well tolerated in vivo and in vitro, which supports continuing efforts to develop silk gels as an alternative to cervical cerclage.

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“…Vários trabalhos destacam que a sutura constitui um dos fatores essenciais para uma rápida e perfeita cicatrização de feridas 3,6,10,12,13 . Entretanto, não existe nenhum relato que descreva o papel da sutura em feridas irradiadas.…”

Section: Introductionunclassified

Efeito de baixas doses de radiação X em feridas suturadas e não suturadas - estudo experimental em ratos

Bóscolo

Almeida

Vizioli

et al. 2000

Pesqui. Odontol. Bras.

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O presente trabalho avaliou o efeito de baixas doses de radiação X no processo de reparação tecidual em feridas suturadas e não suturadas em ratos. Para tanto, foi produzida nos animais uma ferida medindo 20 x 5 mm, sendo suturada ou não, dividindo-se os animais em 4 grupos: controle sem sutura, irradiado sem sutura, controle com sutura e irradiado com sutura. Os animais irradiados foram, no momento da irradiação, protegidos com um avental de chumbo de 2 mm de espessura com uma abertura, a qual permitia que fosse exposta somente a ferida cirúrgica. Cada animal sofreu 18 segundos de irradiação, totalizando 7,4 rad. O processo de reparação tecidual foi avaliado pela coloração por hematoxilina-eosina, verificando-se a morfologia do tecido de granulação e a impregnação argêntica para observação da síntese de colágeno, através da microscopia de polarização. Os resultados mostraram que a radiação, apesar de ter causado atraso, não impediu a reparação tecidual, sendo que o grupo que sofreu irradiação e não foi suturado mostrou maior retardo, quando comparado aos outros grupos.UNITERMOS: Suturas; Radiação ionizante; Cicatrização de feridas. INTRODUÇÃODescoberta há cerca de 100 anos, a radiação X continua a trazer grandes benefícios aos seus usuários. Entretanto, sabe-se da ação lesiva da radiação X sobre o tecido vivo, sendo conhecido também que baixas doses de radiação levam a um retardo no processo de reparação tecidual 1,2,14,18,19 . O retardo produzido pela radiação na cicatrização de feridas, segundo BRYANT et al. 5 (1968)

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The Choice of a Suture to Close Abdominal Incisions

Cited by 68 publications

References 7 publications

Silk-based biomaterials

Silk-based biomaterials

Biocompatibility of a Sonicated Silk Gel for Cervical Injection During Pregnancy: In Vivo and In Vitro Study

Efeito de baixas doses de radiação X em feridas suturadas e não suturadas - estudo experimental em ratos

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