The Chinese herbal medicine formula MSSM-002 suppresses allergic airway hyperreactivity and modulates TH1/TH2 responses in a murine model of allergic asthma

Alleviation of OVA-Induced Airway Inflammation by Flowers ofInula japonicain a Murine Model of Asthma

“…Since IFN-has been reported to inhibit the synthesis of IgE and the differentiation of precursor cells to Th2 cells, an increased level of IFNhas been used to explain the anti-asthmatic effect of therapeutic agents. 13,14) We have demonstrated in the present study that IFE reduced Th2 cytokine production (IL-4, IL-5, and IL-13) in cultured splenocytes, whereas it did not increase IFN-production in cultured splenocytes when compared with the OVA-induced mice (Fig. 4).…”

“…13,19,20) However, the effects of Inulae flos have not previously been elucidated in an asthma model. We have demonstrated for the first time in this study that IFE inhibited the OVA-induced airway inflammation, and that this probably occurred due to decreases in leukocyte infiltration, AHR, Th2 cytokines and IgE production, as well as to mucus secretion in a mouse model of asthma.…”

Visible-to-Near IR Quantum Dot–Based Hypermulticolor High-Content Screening of Herbal Medicines for the Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition

“…Herbal medicine is known to exhibit fewer side effects. 29 Therefore, the efforts to develop herbal-based hair loss medication have been quite active in the industry. We focused on drug development and discovery using diverse herbal medicines based on observation of upregulation/ downregulation of five proteins related to hair growth/hair loss.…”

Traditional Chinese herbal remedies for asthma and food allergy

“…[12;13] We found that ASHMI had comparable effects on AHR and eosinophilic inflammation to the classical 14-herb formulation and showed a high safety profile in an animal model of asthma. [13] Consequently, Wen et al [7] investigated the efficacy and tolerability of this formula on 91 patients in China with moderateto-severe asthma in a double-blind, randomized, placebo-controlled trial comparing ASHMI to oral prednisone therapy. Subjects in the ASHMI group received oral ASHMI capsules (4 capsules, tid, 0.3 g/capsule) and placebo tablets similar in appearance to prednisone.…”

“…While developing botanical drugs, in an attempt to improve the ease of study and quality control while simultaneously maintaining therapeutic efficacy and safety, we developed a simplified formula for the treatment of allergic asthma. [12] ASHMI, a three-herb anti-asthma formulation (Table I), is derived from a 14-herb formula, MSSM-002 [13], which was used to treat asthma in the China-Japan Friendship Hospital in Beijing. [12;13] We found that ASHMI had comparable effects on AHR and eosinophilic inflammation to the classical 14-herb formulation and showed a high safety profile in an animal model of asthma.…”