The chilean superfruit black-berry Aristotelia chilensis (Elaeocarpaceae), Maqui as mediator in inflammation-associated disorders

Cespedes‐Acuña, Carlos L.; Pavón, Natalia; Domı́nguez, Mariana; Alarcón, Julio; Balbontín, Cristián; Kubo, Isao; El-Hafidi, Mohammed; Ávila, José G.

doi:10.1016/j.fct.2016.12.036

Cited by 56 publications

(49 citation statements)

References 79 publications

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“… 98 For example, one study reported that A. chilensis fruit extracts and fractions showed hydroxyl radical-scavenging, antioxidant and anti-inflammatory activity in murine macrophage cells, by reducing lipid peroxidation and down-regulating the expression of both iNOS and COX-2. 92 Moreover, a methanol extract of maqui berries exhibited a cardioprotective effect in an ischemic/reperfusion model in rats, and this effect was associated with the observed antioxidant properties. 97 In another study, the anthocyanin-rich extract of the fruits of A. chilensis reduced the blood glucose levels in insulin-resistant obese hyperglycemic mice, and increased glucose uptake in muscle cells.…”

Section: Maqui Berrymentioning

confidence: 94%

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Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States

Benatrehina

Naman

et al. 2018

Journal of Traditional and Complementary Medicine

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In view of the continuous growth of the botanical dietary supplement industry and the increased popularity of lesser known or exotic botanicals, recent findings are described on the phytochemical composition and biological activities of five selected fruits consumed in the United States, namely, açaí, noni, mangosteen, black chokeberry, and maqui berry. A review of the ethnomedicinal uses of these plants has revealed some similarities ranging from wound-healing to the treatment of fever and infectious diseases. Laboratory studies on açaí have shown both its antioxidant and anti-inflammatory activities in vitro, and more importantly, its neuroprotective properties in animals. Anthraquinones and iridoid glucosides isolated from noni fruit induce the phase II enzyme quinone reductase (QR), and noni fruit juice exhibited antitumor and antidiabetic activities in certain animal models. Antitumorigenic effects of mangosteen in animal xenograft models of human cancers have been attributed to its xanthone content, and pure α-mangostin was shown to display antineoplastic activity in mice despite a reported low oral bioavailability. Work on the less extensively investigated black chokeberry and maqui berry has focused on recent isolation studies and has resulted in the identification of bioactive secondary metabolites with QR-inducing and hydroxyl-radical scavenging properties. On the basis of the safety studies and toxicity case reports described herein, these fruits may be generally considered as safe. However, cases of adulteration found in a commercialized açaí product and some conflicting results from mangosteen safety studies warrant further investigation on the safety of these marketed botanical dietary supplements.

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Section: Maqui Berrymentioning

confidence: 94%

“…77 Other medicinal uses include the management of migraine headaches, fever, kidney pain and ulcers. 23 , 92 In addition to their medicinal properties, the fruits of A. chilensis are consumed as fresh fruits or in the form of jams, wine, tea, and juice. Moreover, these berries represent a source of natural dye used in food coloring.…”

Section: Maqui Berrymentioning

confidence: 99%

Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States

Benatrehina

Naman

et al. 2018

Journal of Traditional and Complementary Medicine

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“…Aristotelia chilensis (Mol) Stuntz (Elaeocarpaceae), commonly known as "maqui" (MQ), is a dioecious berry fruit-bearing native Chilean shrub that thrives in the temperate forests of central to southern Chile and western Argentina. The anti-diabetic, antioxidant, cardio-protective, and anti-hemolytic activities of MQ fruit and leaves have been scientifically reported (Céspedes, El-Hafidi, Pavon, & Alarcon, 2008;Cespedes et al, 2017;Miranda-Rottmann et al, 2002;Tanaka et al, 2013). These biological properties are associated to its chemical composition.…”

Section: Introductionmentioning

confidence: 99%

Improving polyphenolic thermal stability ofAristotelia Chilensisfruit extract by encapsulation within electrospun cyclodextrin capsules

Dicastillo

López‐Carballo

Gavara

et al. 2019

J Food Process Preserv

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Aristotelia chilensis berry, also known as maqui (MQ), has received an increased interest in the last years due to its high polyphenolic content and interesting biological activities. In this work, extractions of maqui fruit were carried out under water, ethanol and ethanol 50%. The hydroalcoholic extract presented the highest polyphenolic content, antioxidant, antimicrobial, and anti‐tyrosinase properties, resulting the most promising extract to be part of a nutraceutical product. Subsequently, because some polyphenols, principally anthocyanins, are highly sensitive to thermal treatments, encapsulation of the most powerful extract was performed by electrospray. Hydroxypropyl‐β‐cyclodextrin (HPβCD) microcapsules containing increased amounts of maqui fruit extract were successfully electrosprayed. Morphological analysis revealed when maqui extract was incorporated at 30%, the distribution of particle diameters showed the most homogeneous ratio. Electrospun HPβCD capsules containing maqui extract, HPβCD/MQ, improved the thermal stability of MQ and preserved total phenolic content when exposed to high‐temperature treatments. Practical applications The interest of consumers toward the consumption of foods rich in polyphenols has grown during the last years. One of the main sources of polyphenols are berry fruits, and maqui is one of Chilean berries with highest polyphenolic content, mainly anthocyanins. This fruit has also shown interesting antioxidant, antimicrobial, and anti‐tyrosinase activities that could contribute to the preservation of foods. The protection of these maqui fruit extract polyphenols through the encapsulation in zeina microparticles broadens the range of applications of this fruit in different applications and food formulations that involve high temperature thermal treatments, such as bakery and dairy products.

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“…It is now known that the excellent properties of this fruit are due to the fact that they are an extremely rich source of bioactive compounds such as phenolic acids, tannins, stilbenes, flavonoids, and anthocyanins [6,10,11]. It is therefore not surprising that maqui has recently been recognized as a "superfruit" [5,12]. Maqui berries are being explored in the pharmaceutical, food, and cosmetics industries as a potential source of bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Microwave-Assisted Extraction for the Recovery of Bioactive Compounds from the Chilean Superfruit (Aristotelia chilensis (Mol.) Stuntz)

et al. 2018

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Maqui berry (Aristotelia chilensis) is being explored in the food industry, and is considered to be one of the healthiest berries due to its bioactive components and high commercial value. Microwave-assisted extraction (MAE) was developed for the determination of total phenolic compounds and anthocyanins from maqui. A Box–Behnken experimental design was employed in conjunction with a response surface methodology to optimize the conditions based on 27 different experiments. The extractions were carried out with four factors (i.e., methanol percentage, pH, temperature, and solvent volume:sample mass ratio), and two responses—total phenolics and anthocyanins. Temperature and methanol percentage were found to be the most influential parameters for total phenolic compounds and anthocyanins, respectively. The optimum MAE conditions were: 65% MeOH in water at pH 2, temperature of 100 °C, and a ratio of 10:0.5 for total phenolics; and 60% MeOH in water at pH 2, temperature of 50 °C, and a ratio of 14:0.5 for anthocyanins. Kinetics assays were carried out and an optimum time of only 2 min was identified for the extractions. Repeatability and intermediate precision were also evaluated, and coefficients of variation below 5% were obtained. The new methods were successfully applied to a foodstuff made with maqui.

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The chilean superfruit black-berry Aristotelia chilensis (Elaeocarpaceae), Maqui as mediator in inflammation-associated disorders

Cited by 56 publications

References 79 publications

Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States

Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States

Improving polyphenolic thermal stability ofAristotelia Chilensisfruit extract by encapsulation within electrospun cyclodextrin capsules

Optimization of Microwave-Assisted Extraction for the Recovery of Bioactive Compounds from the Chilean Superfruit (Aristotelia chilensis (Mol.) Stuntz)

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