The Children Reference Range of Thyroid Hormones in Northern Iran

Ar, Mansourian; Ar, Ahmadi; Saifi, Akhtar; Bakhshandehnosrat, S

doi:10.3923/pjbs.2010.862.865

Cited by 23 publications

(11 citation statements)

References 7 publications

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“…Zurakowski et al .,[11] also showed the indirect association between age and the mean serum levels of T3, TSH and free T4 in the study on 5,817 patients aged 1 month-20 years. However, there are exceptions such as the study conducted by Mansourian et al .,[12] on Iranian population aged 1-21 years. Except for an indirect association between serum T4 and age, they found no association between age and serum TSH and T3 levels.…”

Section: Discussionmentioning

confidence: 99%

Serum thyroid stimulating hormone, total and free T4 during the neonatal period: Establishing regional reference intervals

Sheikhbahaei

Mahdaviani

Abdollahi

et al. 2014

Indian J Endocr Metab

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Context:Congenital hypothyroidism (CH), the most common etiology of preventable mental retardation in children, is estimated to be more prevalent among Asian population.Aims:Since thyroid function tests (TFTs) varied among different ages and geographical regions, in this study, the neonatal thyroid reference intervals in a healthy neonatal population is determined for the first time in Iran.Settings and Design:A cross-sectional study performed on 246 healthy term newborns aged between 2 days and 1 month.Materials and Methods:Blood samples were obtained by venipuncture from all subjects. The median, 2.5th, 5th, 95th, and 97.5th percentile of serum thyroid-stimulating hormone (TSH), as well as the total and free T4 were assessed among different age groups.Statistical Analysis Used:Predictive Analytics Software (PASW Statistics 18) was used for the analysis.Results:Serum TSH, total and free T4 concentration peaked in 5th to 7th days of life, continued over 2 weeks, then decreased and started reaching to adult reference range. A significant negative correlation between age and serum concentration of TSH (P = 0.02), total T4 (P = 0.01) and free T4 (P = 0.01) was found.Conclusion:This study yielded fairly different values for TFTs compared compared values found in other countries and also different from values reported for laboratory kits we used. These differences were assumed to be due to variations in ethnicity, age, and laboratory methods used. Due to the lack of international standardization, conducting multicenter studies helps in making a more precise evaluation of thyroid status in neonates.

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Section: Discussionmentioning

confidence: 99%

Serum thyroid stimulating hormone, total and free T4 during the neonatal period: Establishing regional reference intervals

Sheikhbahaei

Mahdaviani

Abdollahi

et al. 2014

Indian J Endocr Metab

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“…On the other hand, when reference ranges of thyroid hormones in children established in the past, shown in Table 3, were referred to, the reference ranges were found to be rather unreliable for the definition of normal thyroids, as compared with the criteria used in our study. The reference ranges of FT3, FT4 and TSH established in our study, even though the number of subjects studied was fewer, are considered to be more reliable [2,[5][6][7][8][10][11][12][13][14][15][16][17][18][19]. We conducted this study using data accumulated over the past more than 9 years.…”

Section: Discussionmentioning

confidence: 99%

Determination of pediatric reference levels of FT3, FT4 and TSH measured with ECLusys kits

et al. 2013

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It Is essentIal to establish reference ranges for pediatric age groups to diagnose abnormalities of thyroid function in children. In Japan, reference ranges for thyroid hormones free triiodothyronine (FT3) and free thyroxine (FT4) as determined by radioimmunoassay (RIA) and reference ranges for thyroid stimulating hormone (TSH) as determined by immunoradiometric assay (IRMA) have been reported [1,2], even though they have been derived from assays of rather small sample sizes. Subsequently, a large-scale study was conducted in 1996 by a Pediatric Reference Range Study Group and reference ranges for pediatric age groups were reported [3]. More than one and half decades have elapsed since then, and reference ranges based abstract. Reference ranges for serum thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in children were set using the assay kits currently used in clinical settings. A total of 342 children (111 males and 231 females) who were negative for antithyroid antibodies (TgAb, TPOAb) and were found to have no abnormalities on ultrasonographic examination of the thyroid gland were divided into 6 age groups: 4-6 years (45 children), 7-8 years (40), 9-10 years (53), 11-12 years (65), 13-14 years (83), and 15 years (56) for the study. FT3, FT4 and TSH levels were determined by electrochemiluminescence immunoassay (ECLIA) (ECLusys FT3, FT4 and TSH).The reference range for FT3 (pg/mL) was 2.91-4.70 for the age group of 4-6 years, 3.10-5.10 for the age group of 7-8 years, 3.10-4.87 for the age group of 9-10 years, 2.78-4.90 for the age group of 11-12 years, 2.77-4.59 for the age group of 13-14 years, and 2.50-4.64 for the age group of 15 years . The reference range for FT4 (ng/dL) was 1.

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“…Other T3 and T4 play the main roles in metabolism of the thyroid hormones. Their measurement is the basis for assessment of thyroid hormones abnormalities [5,[16][17][18][19].…”

Section: Thyroid Function Testsmentioning

confidence: 99%

“…In subclinical hypothyroidism, thyroid hormones are in normal range but the serum TSH is elevated. In some clinical settings, subclinical hypothyroidism is treated as overt hypothyroidism since it is believed to be the pre-condition for hypothyroidism [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Thyroid disease may be sometimes missed in the elderly population because of the similarities between thyroid hormonesrelated clinical manifestation and normal aging physiological changes.…”

Section: Introductionmentioning

confidence: 99%

Hypothyroidism in Elderly Population: A Review

Saifi¹,

Ahmadi²,

Mansourian³

2017

jcbr

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Many metabolic disorders originate from thyroid disorders, particularly from hypothyroidism. Hypothyroidism commonly occurs in elderly subjects, particularly in women. Subclinical form of hypothyroidism can be diagnosed via laboratory testing. It is crucial to check thyroid hormone profile in elderly subjects. Subclinical hypothyroidism can eventually lead to overt hypothyroidism if left untreated. Treatment of subclinical hypothyroidism could be helpful in preventing the complications of hypothyroidism, particularly among the elderly population. The main aim of this review was to investigate subclinical hypothyroidism among elderly subjects.

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The Children Reference Range of Thyroid Hormones in Northern Iran

Cited by 23 publications

References 7 publications

Serum thyroid stimulating hormone, total and free T4 during the neonatal period: Establishing regional reference intervals

Serum thyroid stimulating hormone, total and free T4 during the neonatal period: Establishing regional reference intervals

Determination of pediatric reference levels of FT3, FT4 and TSH measured with ECLusys kits

Hypothyroidism in Elderly Population: A Review

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