The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study

Abstract

Background COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. Methods This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. Conclusion CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients.

Post-acute COVID-19 syndrome

“…Similarly, no DVT was seen in 390 participants (selected using a stratified sampling procedure to include those with a higher severity of acute COVID-19) who had ultrasonography of lower extremities in the post-acute COVID-19 Chinese study 5 . Larger ongoing studies, such as CORONA-VTE, CISCO-19 and CORE-19, will help to establish more definitive rates of such complications 86,87 .…”

Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART—a UK, multicentre, observational study

“…As part of the patient consent process, it will be explicitly requested that anonymised data and images can be shared with other national and global research initiatives, for efficiency in data collection and sharing across other nationally prioritised UK COVID studies (e.g. C-MORE, P-HOSP-COVID and CISCO-19 [Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19]) [ 47 ], as well as with other international CMR studies and registries e.g. the international SCMR COVID-19 registry.…”

Cardiovascular and Renal Risk Factors and Complications Associated With COVID-19

“…Microvascular thrombosis has previously been demonstrated at autopsy within pulmonary tissue and this may also be a cause of coronary microvascular necrosis or dysfunction (147). The results of mechanistic imaging studies which feature assessment of coronary microvascular perfusion and myographic vascular function following SARS-CoV-2 infection in patients with concomitant coronary assessment are awaited (148).…”