The Chemotherapy of Helminth Infestations

Lamson, Paul D.; Ward, Charlotte B.

doi:10.2307/3271811

Cited by 20 publications

(6 citation statements)

References 6 publications

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“…Historically, thymol (found in oil of thyme), santonin (derived from buds of the local Artemisia spp.) and ascaridol (isolated from Chenopodium oil) were used in the late nineteenth and early twentieth century for the treatment of ascarids and hookworms in humans (Ferrell, 1914; Kaplan et al, 2014; Lamson and Ward, 1932). Terpene and terpenoid biomolecules, particularly monoterpenes and sesquiterpenes, found in essential oils have been identified as promising anthelmintic compounds and are of great pharmaceutical interest (Jaradat et al, 2016; Katiki et al, 2011; Lei et al, 2010; Pessoa et al, 2002; Squires et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors

Choudhary

Marjianović

Wong

et al. 2019

International Journal for Parasitology: Drugs and Drug Resistan

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The ongoing and widespread emergence of resistance to the existing anti-nematodal pharmacopeia has made it imperative to develop new anthelminthic agents. Historically, plants have been important sources of therapeutic compounds and offer an alternative to synthetic drugs. Monoterpenoids are phytochemicals that have been shown to produce acute toxic effects in insects and nematodes. Previous studies have shown nicotinic acetylcholine receptors (nAChRs) to be possible targets for naturally occurring plant metabolites such as carvacrol and carveol. In this study we examined the effects of monoterpenoid compounds on a levamisole sensitive nAChR from Oesophagostomum dentatum and a nicotine sensitive nAChR from Ascaris suum. We expressed the receptors in Xenopus laevis oocytes and used two-electrode voltage-clamp to characterize the effect of various compounds on these cys-loop receptors. At 100 μM the majority of these compounds acted as antagonists. Interestingly, further experiments revealed that both 0.1 μM and 10 μM menthol potentiated acetylcholine and levamisole responses in the levamisole sensitive receptor but not the nicotine sensitive receptor. We also investigated the effects of 0.1 μM menthol on the contractility of A. suum somatic muscle strips. Menthol produced significant potentiation of peak contractions at each concentration of acetylcholine. The positive allosteric modulatory effects of menthol in both in vivo and in vitro experiments suggests menthol as a promising candidate for combination therapy with cholinergic anthelmintics.

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Section: Introductionmentioning

confidence: 99%

Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors

Choudhary

Marjianović

Wong

et al. 2019

International Journal for Parasitology: Drugs and Drug Resistan

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“…Numerous alkaloids, including pelletierine, eserine, morphine, quinine and strychnine, have at one time or another been credited with nematocidal properties (see the table given by Lamson & Ward, 1932). According to our results, however, simple derivatives of these and a number of other alkaloids are devoid of action upon nematodes (see Fig.…”

Section: Results and Interpretationsmentioning

confidence: 52%

“…to produce the same effect. Lamson & Ward (1932) were of opinion that hexylresorcinol acts primarily upon the nematode cuticle, since worms that have been killed by means of this drug show cuticular blistering. Our observations, however, show that the worm fragments are completely paralysed long before any blistering can be detected, and we cannot agree that hexylresorcinol owes its powerful nematocidal efficiency to its action upon the cuticle.…”

Section: Results and Interpretationsmentioning

confidence: 99%

An in vitro method for the chemotherapeutic investigation of anthelminthic potency

Baldwin

1943

Parasitology

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A method is described for the detection of anthelminthic potency. The procedure does not call for exceptional technical skill, is relatively economical of drugs and living material alike, and is rapid and convenient in application. It has certain limitations such as are inherent in any in vitro method, and a special limitation in that it is not applicable to the study of drugs which act otherwise than on the neuro-muscular mechanisms of nematodes. Within these limitations it responds to compounds of known anthelminthjc efficiency and shows little or no response to compounds known to be devoid of anthelminthie value. Approximate quantitative data can be obtained with its aid, the reactions provoked by a given drug are substantially the same in different individuals, and each test provides a visible record of the influence of the drug under examination.We do not claim that this procedure can in any sense replace experiments upon infested hosts, but must rather be followed up by such experiments when a promising degree of anthelminthie potency has been detected with its aid. We do, however, believe that it has a very real usefulness within the field to which its application is limited. As a preliminary device which allows the selection of promising compounds from large groups of new synthetic products it has already demonstrated its value in tests carried out in this laboratory on a series of about fifty new compounds prepared by Prof. Friedmann.

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“…PROCEDURE Different anthelminthics undoubtedly act in different ways. Lamson and Ward (1932) have divided anthelminthics into five groups according to whether they (i) cause temporary narcosis or paralysis followed by recovery, (ii) narcosis or paralysis followed by death, (iii) injury to the cuticle, (iv) digestion of the parasites, or (v) unexplained death. All the drugs in general use have one property in common when applied to our test preparations :.…”

Section: Choice Of a M Ethodmentioning

confidence: 99%

Untitled

1948

British Journal of Pharmacology and Chemotherapy

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The Chemotherapy of Helminth Infestations

Cited by 20 publications

References 6 publications

Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors

Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors

An in vitro method for the chemotherapeutic investigation of anthelminthic potency

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