The Chemopreventive Effect of Taxifolin Is Exerted through ARE-Dependent Gene Regulation

Lee, Saet Byoul; Hyun, Kwang; Dangaa, Selenge; Solongo, Amgalan; Nho, Chu Won

doi:10.1248/bpb.30.1074

Cited by 90 publications

(51 citation statements)

References 30 publications

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“…Both pinocembrin and pinobanksin possess antimutagenic properties, in particular against ofloxacin-induced mutagenicity in Euglena gracilis; whereas pinobanksin is able to inhibit the peroxidation of low density lipoprotein and to scavenge peroxyl radicals (Ondrias et al 1997;Neacsu et al 2007). Taxifolin exerts a number of protective and anticancer effects (Lee et al 2007;Luo et al 2008;Rogovskii et al 2010), and enhances the antibiotic activity in combined therapies . Antimicrobial activity (Ango et al 2012), the ability to reduce reactive oxygen species (ROS) formation in polymorphonuclear cells (Kang et al 2010), and activity to reduce lipid peroxidation (Redzynia et al 2009) have been reported for dihydrokaempferol.…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble Components of Pinus pinaster Wood

Conde¹,

Fang²,

Hemming³

et al. 2013

BioResources

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Aqueous fractionation of wood has been proposed as a suitable processing method for biorefineries. When treatments are performed under low severity conditions, water-soluble components (which could be detrimental in further processing stages) are removed, whereas polysaccharides, lignin, and other water-insoluble constituents remain in solid phase with little alteration. In order to explore the presence of added-value products in aqueous extracts from Pinus pinaster wood, different samples (heartwood and sapwood with and without knots) were extracted with water at 130 to 140 ºC, and the resulting solutions were assayed for yield and composition (by GC-FID, GC-MS, and HPLC). The major extract components, such as polysaccharide-derived products, simple phenolics, stilbenes, lignans, flavonoids, organic acids, jubaviones, steryl esters, and triglycerides, were identified and quantified. In order to assess a possible application of the extracts, their antioxidant activity was measured using the Trolox Equivalent Antioxidant Capacity assay.

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Section: Introductionmentioning

confidence: 99%

Water-Soluble Components of Pinus pinaster Wood

Conde¹,

Fang²,

Hemming³

et al. 2013

BioResources

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“…Taxifolin, a flavanolol that is also present in silymarin extract, is thought to play a role in the anti-tumor activity of this mixture and has been reported to inhibit ovarian cancer cell growth in a dose-dependent fashion and as a preventative measure against skin carcinogenesis [7][8][9]. The remainder of the silymarin extract has yet to be fully characterized but is believed to be comprised of polymeric and oxidized polyphenols [10].…”

Section: Introductionmentioning

confidence: 99%

A sensitive LC–MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma

Brinda

Zhu

Markowitz

2012

Journal of Chromatography B

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“…EROD activity was measured as previously described with minor modifications, 15,16) and QR activity was measured as described previously, also with slight modifications. [17][18][19] Hepa1c1c7 cells (1ϫ10 4 cells per well) were plated onto 96-well plates and incubated for 24 h prior to treatment. Media containing various concentrations of youngiasides was then added and incubated for an additional 24 h. The absorbance at 610 nm was measured five times at 50 s intervals using a Synergy HT Multi-microplate reader.…”

Section: Chemicalsmentioning

confidence: 99%

Bi-Functional Induction of the Quinone Reductase and Cytochrome P450 1A1 by Youngiasides via Nrf2-ARE and AhR-XRE Pathways

Yun

Lee

et al. 2010

Biological & Pharmaceutical Bulletin

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Cancer chemoprevention is defined as the use of phytochemicals (naturally occurring compounds or their synthetic derivatives) from dietary foods or natural products to inhibit, delay or reverse carcinogenesis or prevent the development of cancer.1,2) The important strategy of cancer chemoprevention aims to reduce the risk of cancer through modulation of detoxification enzymes involved in metabolic activation. The detoxification/excretion of carcinogens is one of the representative mechanisms of action of chemopreventive agents. 3)Dietary phytochemicals can be classified into two groups, termed mono-and bi-functional inducers. Mono-functional inducers upregulate a number of phase II detoxification enzymes, including quinone reductase (QR, also known as NAD(P)H: quinone oxidoreductase, NQO1) and glutathione S-transferases (GSTs). The bi-functional inducers upregulate a similar array of phase II enzymes as well as a number of phase I enzymes including cytochrome P450 1A1 (CYP1A1). 4) Since phase I enzymes are involved in both bioactivation and detoxification of carcinogens, the monofunctional inducers, which upregulate only phase II enzymes, are thought to be more closely associated with chemoprevention than are bi-functional inducers that upregulate both phase I and II enzymes. However, the bi-functional inducers can in some cases exert synergistic effects in cancer chemoprevention. Oltpraz, a plant-derived compound, is a promising bi-functional inducer and is found to increase levels of not only phase II, but also phase I, enzymes. 5)These inducers are known to regulate genes that encode detoxification enzymes and which involve two important promoter sites. One site is known as the antioxidant response element (ARE) associated with induction of phase II detoxification enzymes (mono-functional induction), 6,7) while the second is the xenobiotic response element (XRE) located in the promoters of genes encoding phase II, and some phase I, cytochrome P450 enzymes (bi-functional induction). 8) AREand XRE-containing promoters can be activated by binding of specific transcription factors such as nuclear factor E2 (NF-E2) p45-Nrf2 and AhR, respectively. Nrf2 is a member of the CNC (cap'n'collar) basic leucine zipper (bZIP) transcription factor family and AhR is a member of the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family. 9) Nrf2 is known to translocate into the nucleus and recruit Maf proteins, which is followed by the activation of transcription of ARE-dependent genes.10) The ligand-bound AhR translocates into the nucleus where it binds as a heterodimer with the AhR nuclear translocator (Arnt) and activates the transcription of XRE-dependent genes.11) In addition, it was recently revealed that Nrf2 is one of the AhR target genes. 12,13) In Korea, early sprouts have been used of the compositae plant Crepidiastrum denticulatum (HOUTT.) PAK & KAWANO; however, induction of QR by this plant has not yet been reported. Further, the chemical structures of youngiaside A, B, and C isolated from C. denticulatum have been...

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The Chemopreventive Effect of Taxifolin Is Exerted through ARE-Dependent Gene Regulation

Cited by 90 publications

References 30 publications

Water-Soluble Components of Pinus pinaster Wood

Water-Soluble Components of Pinus pinaster Wood

A sensitive LC–MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma

Bi-Functional Induction of the Quinone Reductase and Cytochrome P450 1A1 by Youngiasides via Nrf2-ARE and AhR-XRE Pathways

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