The Chemistry of the Benzimidazoles.

Bis[2,6-bis(1-methyl-1H-benzimidazol-2-yl-κN3)pyridine-κN]zinc dipicrate methanol disolvate

“…For the applications of benzimidazole derivatives, see : Horton et al (2003); Wang et al (1994); Cowan (1998); Liu et al (2004Liu et al ( , 2011Wright (1951). For a related crystal structure, see: Huang et al (2010).…”

Diphosphorus Tetraiodide (P2I4): An Efficient Catalyst for Synthesis of 2-Aryl-1,3-benzazoles via Cyclocondensation of o-Amino/Mercaptan/Hydroxy Anilines with Aryl Acids

“…There are several classical methods in the literature to obtain 1,3-benzazoles which involves the condensation reactions of either o-phenylenediamine, o-aminobenzenethiol, or o-aminophenol with substituted carboxylic acids, aldehydes, acyl chlorides, or nitriles [9][10][11][12][13][14][15]. Alternatively, benzimidazoles have also been synthesized using transition-metal catalyzed amination followed by condensation [16] and cyclization of o-nitroaniline derivatives with aryl isothiocyanates [17].…”

A novel approach to synthesis of flibanserin

“…A variety of benzimidazoles are in used, like Thiabendazole, Flubendazole (antihelminthic), Omeprazole, Lansoprazole (anti-ulcerative) and Astemizole (anti-histaminic). The chemistry and pharmacology of benzimidazoles have been of great interest to medicinal chemistry [7,8] , because of its derivatives possessed various biological activities such as anti-oxidant [9,10], anti-microbial [11][12][13][14][15][16] , antihelmentic [17][18][19], anti-cancer [20], anti-hypertensive [21], anti-neoplastic [22], anti-inflammatory [23,24], analgesic [25], anti-protozoal [26,27], anti hepatitis activities [28] and also shows anti-depressant activity [29].…”