The chemistry of rhenium in nuclear medicine

Blower, Philip J.; Prakash, S.

doi:10.1016/s1062-239x(99)80029-7

Cited by 44 publications

(45 citation statements)

References 76 publications

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“…No further changes were observed in the 1 H NMR spectra of 1 when the temperature was lowered to below -10°C. The several CH 2 resonances in the spectra of 1 were assigned based on 2D homonuclear [ 1 H, 1 H] gradient COSY (gCOSY) and heteronuclear [ 1 H, 13 C] gradient heteronuclear single quantum correlation (gHSQC) experiments, which were run at -10°C and 60°C. The 13 C NMR spectrum of 1 recorded at 60°C also showed only one peak for each CH 2 carbon, although they are relatively broad and the CH 2 (a) and CH 2 (d) peaks overlap.…”

Section: Nmr Studiesmentioning

confidence: 99%

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^99mTc^I/Re^I Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation

Moura¹,

Gano²,

Santos³

et al. 2011

Eur J Inorg Chem

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Tricarbonyl MI (M = Re, 99mTc) complexes of a new tridentate cysteamine based chelator have been synthesized and fully characterized. To gain an insight into the usefulness of this new chelator for labeling biomolecules with a fac‐[M(CO)3]+ core, the ligand framework has been functionalized with a N‐(dialkylaminoalkyl) pharmacophore. The corresponding 99mTcI complexes showed moderate affinity for melanin and moderate cell uptake by B16F1 murine melanoma cells, and therefore deserve further evaluation in vivo as radioactive probes for the detection of melanomas.

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Section: Nmr Studiesmentioning

confidence: 99%

“…[1] Moreover, nonradioactive Re complexes are often used as reference compounds for the assignment of the chemical identity of the 99m Tc congeners. For radiopharmaceutical research, Re and Tc offer the possibility of exploring a large variety of oxidation states, metallic cores, and bifunctional chelators.…”

Section: Introductionmentioning

confidence: 99%

^99mTc^I/Re^I Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation

Moura¹,

Gano²,

Santos³

et al. 2011

Eur J Inorg Chem

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“…Recrystallization of 1 from methanol and acetonitrile yields [Re(CO) 3 (MeOH) 2 Br] (2) and [Re(CO) 3 -(CH 3 CN) 2 Br] (3), respectively. As shown in Fig.…”

Section: (H 2 O) 3 ]Br Ae 2h +mentioning

confidence: 99%

“…The recent significant expansion of the chemistry of technetium and rhenium reflects in part their applications to diagnostic and therapeutic nuclear medicine, respectively [1,2]. The chemistry of these Group 7 congeners is characterized by stable compounds in oxidation states ranging from -1 to +7.…”

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confidence: 99%

A convenient synthesis, chemical characterization and reactivity of [Re(CO)3(H2O)3]Br: the crystal and molecular structure of [Re(CO)3(CH3CN)2Br]

Lazarova

James

Babich³

et al. 2004

Inorganic Chemistry Communications

135

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“…Once delivered to the bone surface and incorporated selectively into bone mineral in skeletal metastases the radioactive rhenium complex irradiates the area causing pain relief. Neither the cause of pain nor the mechanism of its relief by irradiation are well understood yet (Blower & Prakash, 1999).…”

Section: B Group 7 Metals Relevant To Nm: Technetium and Rheniummentioning

confidence: 99%

Contribution of electrospray mass spectrometry for the characterization, design, and development of nitrido technetium and rhenium heterocomplexes as potential radiopharmaceuticals

Tisato

Bolzati

Porchia

et al. 2004

Mass Spectrometry Reviews

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Diagnostic nuclear medicine (NM) is among the imaging procedures (together with X-ray, computerized tomography, magnetic resonance, and echography) the clinicians can routinely adopt to image organs or tissues and related disorders. (99m)Tc-based agents are the radiopharmaceuticals of election in diagnostic NM because of the ideal physical properties of the 99mTc nuclide (t1/2 6.01 hr; Egamma 142 keV), low cost, and easy availability through the commercial 99Mo/99mTc generator, and chemical versatility of the element. In the last two decades the synergistic work of clinics, pharmacologists, and coordination chemists has had a tremendous impact in the development of new 99mTc-based radiopharmaceuticals through the recognition of the structure at the molecular level of the agent utilized. This has been achieved by studying the physico-chemical properties of the long-lived 99gTc (t1/2 2.11 x 10(5) year; Ebeta 292 keV) and third-row congener Re isostructural compounds. Electrospray ionization mass spectrometry (ESI-MS) and collision experiments (MS/MS) represent valuable analytical techniques suitable for the characterization of both technetium and rhenium complexes relevant to NM. Unequivocal structural identification of these bioinorganic compounds, either simple coordination complexes ("essential radiopharmaceuticals") or more sophisticated structures carrying bioactive fragments ("receptor-specific" radiopharmaceuticals), can be realized in combination with multinuclear NMR spectroscopy. MS/MS experiments provide useful information on the different metal-ligand bond strength, and comparison of the fragmentation profiles of isostructural technetium and rhenium compounds give additional details on the role played by the metal in determining preferred decomposition channels. The analysis of these data contribute to design novel synthetic strategies for the obtainment of technetium and rhenium compounds relevant to NM. The chemistry underlying the production of a new class of potential radiopharmaceuticals including a terminal nitrogen bond and a mixed coordination sphere comprising heterodiphosphines and/or dithiocarbamates (DTC) is presented in detail together with the ESI-MS and MS/MS investigations.

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The chemistry of rhenium in nuclear medicine

Cited by 44 publications

References 76 publications

^99mTc^I/Re^I Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation

^99mTc^I/Re^I Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation

A convenient synthesis, chemical characterization and reactivity of [Re(CO)3(H2O)3]Br: the crystal and molecular structure of [Re(CO)3(CH3CN)2Br]

Contribution of electrospray mass spectrometry for the characterization, design, and development of nitrido technetium and rhenium heterocomplexes as potential radiopharmaceuticals

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The chemistry of rhenium in nuclear medicine

Cited by 44 publications

References 76 publications

99mTcI/ReI Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation

99mTcI/ReI Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation

A convenient synthesis, chemical characterization and reactivity of [Re(CO)3(H2O)3]Br: the crystal and molecular structure of [Re(CO)3(CH3CN)2Br]

Contribution of electrospray mass spectrometry for the characterization, design, and development of nitrido technetium and rhenium heterocomplexes as potential radiopharmaceuticals

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^99mTc^I/Re^I Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation

^99mTc^I/Re^I Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation