The Chemistry of Quinolines.

Facile synthesis of 2-substituted quinolines and 3-alkynyl-2-aryl-2H-Indazole via SnCl2-mediated reductive cyclization

“…5 Skraup reaction, Combes synthesis, Friedländer synthesis, Pfitzinger reaction and Doebner-Miller reaction 6 are some of the well-known synthetic methods for the synthesis of quinoline derivatives. Though many of these methods are effective they often require longer reaction time.…”

First Examples of Doebner-Miller Reaction in Flow: Efficient Production of 2-Methylquinoline Derivatives in Water

“…Quinoline analogues are also a building block for the preparation of a wide range of value-added products used in various industries such as food, pharmaceuticals, and cosmetics. Various conventional reactions such as Skraup reaction [1], Doebner-Miller reaction [2], Friedlander reaction [3], Pfitzinger reaction [4], Conrad-Limpach reaction [5], and Combes reaction [6] were reported depending on the substitution of the target compound. A large number of quinoline derivatives, 2-methylquinoline (quinaldine) for example, have showed significant biological activities, such as antimalarial [7], analgesic [8], anti-inflammatory [9], anticancer [10], antibacterial [11], and antifungal [12].…”

Synthesis of Novel Quinoline‐substituted 1,4‐dihydropyridine Derivatives via Hantzsch Reaction in Aqueous Medium: Potential Bioactive Compounds

“…Remarkable pharmacological properties have been associated with quinoline derivatives. As a consequence, research on diverse aspects of quinolines has attracted much attention . These compounds have displayed many applications in medicinal chemistry such as antimicrobial, antivirus, anti‐inflammatory, antimalarial, antitumor, and antiparasitic activities .…”

“…As a consequence, research on diverse aspects of quinolines has attracted much attention [1][2][3][4][5][6][7]. These compounds have displayed many applications in medicinal chemistry such as antimicrobial, antivirus, anti-inflammatory, antimalarial, antitumor, and antiparasitic activities [1][2][3][4][5][6][7]. On the other hand, 2-chloroquinoline-3-carbaldehydes have been used as highly diverse starting materials in the synthesis of a wide variety of quinoline derivatives [8,9].…”