The Chemistry of N-Hydroxyamidoximes, N-Aminoamidoximes, and Hydrazidines

An Ion‐Crosslinked Supramolecular Hydrogel for Ultrahigh and Fast Uranium Recovery from Seawater

“…However, the proven uranium ore reserves on land are limited, and can only provide for about 70 years of consumption of global nuclear energy . To efficiently recover uranium from seawater, for the long‐term sustainable development of nuclear power, many types of uranium adsorbents have been developed, such as inorganic materials, synthetic organic and polymeric materials, various nanostructured adsorbents including grafted polymeric porous supports, metal–organic frameworks, covalent organic frameworks, porous carbons, porous aromatic frameworks, porous‐organic polymers, and recent protein/biomass‐based materials . For all this, a great number of technical difficulties are associated with massive uranium extraction from seawater, because of the ultralow concentrations of uranium and the severe interference of massive coexisting ions, as well as the complicated biological environment which can corrode/destroy the adsorbents and devices .…”

“…However, the proven uranium ore reserves on land are limited, and can only provide for about 70 years of consumption of global nuclear energy. [2] To efficiently recover uranium from seawater, for the long-term sustainable development of nuclear power, many types of uranium adsorbents have been developed, such as inorganic materials, [3][4][5] synthetic organic and polymeric materials, [6][7][8] various nanostructured adsorbents [9][10][11][12][13][14][15] including grafted polymeric porous supports, [9] metal-organic www.advmat.de www.advancedsciencenews.com or good selectivity, [18,40] amidoxime-functionalized hydrogels have both. [41,42] However, to improve the hydrophilicity of the poly(amidoxime) (PAO) and other amidoxime-functionalized polymers, additional hydrophilic hydrogel 3D networks are commonly introduced.…”

Bioactive heterocycles containing endocyclic N-hydroxy groups

“…All these effects were found to be potentially useful in the treatment of various pathologies, such as cancer, viral infections, rheumatoid arthritis and multiple sclerosis [12-20]. Furthermore, N -hydroxyamidoximes and N -hydroxyureas also showed antiprotozoal, antibacterial, anti-human immunodeficiency virus (HIV) and anti-leishmania activity [21,22]. In particular, several compounds belonging to these classes proved to be useful drugs in clinical or preclinical studies, such as the HDAC inhibitors suberoylanilide hydroxamic acid (SAHA, Vorinostat, 12 in Fig.…”

Synthesis and Characterization of para‐Substituted N,N′‐Dihydroxybenzamidines and Their Derivatives as Model Compounds for a Class of Prodrugs

“…Katritzky et al stated that derivative 7d was more stable, [21] basing this on a 1914 publication by Ley et al [17] Unfortunately, Ley never studied the stability of the pure substance at room temperature but analyzed complex salts of 7/7Јd with metals. However, there is a slight tendency for O-monomethylated derivatives predominantly to contain tautomers of type 5, whereas in O-monobenzylated derivatives tautomers 7Ј prevail (Scheme 4).…”

“…However, there is a slight tendency for O-monomethylated derivatives predominantly to contain tautomers of type 5, whereas in O-monobenzylated derivatives tautomers 7Ј prevail (Scheme 4). [21] NMR measurements in DMSO display NH groups (large splitting of signals, of the order of 80-90 Hz, in the decoupled HMBC spectrum), showing the presence of one NH group for each tautomeric structure ( Figure 2, Table 3). Moreover, Katritzky et al misunderstood the abbreviation "Me" used by Ley et al for metal and not for methyl.…”