The Chemistry of Blood Coagulation

A Brief Historical Review of the Waterfall/Cascade of Blood Coagulation

“…This pathway had been proposed in the early 1900s by Morawitz, who described thrombokinase as a coagulant activity from platelets or damaged tissue (39). Howell (40) called the clot-accelerating activity from tissue, thromboplastin, a complex that converted prothrombin to thrombin.…”

Purification of Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase

“…Upon addition to blood, the proteases of the intrinsic coagulation cascade are slowly neutralized by antithrombin (AT) 1 (reviewed in Ref. 1).…”

“…1). This inhibition is due to the formation of 1:1 enzyme⅐AT complexes whose production is greatly accelerated by the mast cell product, heparin (2).…”

Physiology of Hemostasis

“…Later, Rudolph Virchow in 1860 described clots and their tendency to embolize [ 8 ]. Based on these developments, Paul Morawitz in 1905 proposed the classic theory of coagulation in which prothrombin by calcium activation caused the generation of thrombin which transformed fi brinogen to fi brin [ 9 ]. 1.…”