The chemistry and utility of hexafluoroisobutylene (HFIB) and hexafluoroisobutylene oxide (HFIBO)

Hexafluoroisobutylation of enolates through a tandem elimination/allylic shift/hydrofluorination reaction

“…12-15 Nevertheless, this elimination reaction remains the main obstacle for effective synthesis of trifluoromethylated compounds using α-CF 3 -vinyl group or more generally α-CF 3 carbanion chemistry (Scheme 1, top). 16,17 Another disadvantage, is that hexafluoroisobutene is a gas at room temperature 18 and applying this method would require specific safety equipment and make the measurement of small quantities inaccurate.…”

“…1, top). 16,17 Another disadvantage is that hexauoroisobutene is a gas at room temperature 18 and applying this method would require specic safety equipment and make the measurement of small quantities inaccurate.…”