“…12-15 Nevertheless, this elimination reaction remains the main obstacle for effective synthesis of trifluoromethylated compounds using α-CF 3 -vinyl group or more generally α-CF 3 carbanion chemistry (Scheme 1, top). 16,17 Another disadvantage, is that hexafluoroisobutene is a gas at room temperature 18 and applying this method would require specific safety equipment and make the measurement of small quantities inaccurate.…”
Section: This Workmentioning
confidence: 99%
“…1, top). 16,17 Another disadvantage is that hexauoroisobutene is a gas at room temperature 18 and applying this method would require specic safety equipment and make the measurement of small quantities inaccurate.…”
The isobutyl side chain is a highly prevalent hydrophobic group in drugs, and it notably constitutes the side chain of leucine. Its replacement by a hexafluorinated version containing two CF3...
“…12-15 Nevertheless, this elimination reaction remains the main obstacle for effective synthesis of trifluoromethylated compounds using α-CF 3 -vinyl group or more generally α-CF 3 carbanion chemistry (Scheme 1, top). 16,17 Another disadvantage, is that hexafluoroisobutene is a gas at room temperature 18 and applying this method would require specific safety equipment and make the measurement of small quantities inaccurate.…”
Section: This Workmentioning
confidence: 99%
“…1, top). 16,17 Another disadvantage is that hexauoroisobutene is a gas at room temperature 18 and applying this method would require specic safety equipment and make the measurement of small quantities inaccurate.…”
The isobutyl side chain is a highly prevalent hydrophobic group in drugs, and it notably constitutes the side chain of leucine. Its replacement by a hexafluorinated version containing two CF3...
The Chemistry and Utility of Hexafluoroisobutylene (HFIB) and Hexafluoroisobutylene Oxide (HFIBO) -[121 refs.]. -(MURPHY, P. M.; J. Fluorine Chem. 156 (2013) 345-362, http://dx.
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