The chemistry and biology of vanadium compounds in cancer therapeutics

Kioseoglou, Efrosini; Petanidis, Savvas; Gabriel, Catherine; Salifoglou, Athanasios

doi:10.1016/j.ccr.2015.03.010

Cited by 227 publications

(114 citation statements)

References 126 publications

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“…In addition to the widely known therapeutic properties of oxidovanadium(V) compounds, such as their insulin-mimetic activity, there is a growing interest in vanadium compounds as potential therapeutic agents for the treatment of cancer [15][16][17]. A complex of this metal with an o-HVa-derived Schiff base ligand has been determined to bind to CT-DNA in a nonclassical intercalative mode and to possess a strong affinity with the BSA protein, inducing conformational changes [18].…”

Section: Scheme 1 Inhovamentioning

confidence: 99%

A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand. A combined experimental and theoretical study and cytotoxity against K562 cells

et al. 2017

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A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand. A combined experimental and theoretical study and cytotoxity against K562 cells. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Scheme 1 Inhovamentioning

confidence: 99%

A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand. A combined experimental and theoretical study and cytotoxity against K562 cells

et al. 2017

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“…In contrast, high levels Vitamin Cof ROS are cytotoxic to the cells and trigger apoptotic mechanisms. Therefore, it has been proposed that the cytotoxic efects of vanadium compounds should be used to generate ROS and reactive nitrogen species to combat cancer cell lines [48,49]. Of all the proposed mechanisms of V(V) toxicity, the induction of oxidative stress is of particular importance for biological systems [50,51].…”

Section: Protective Efects Of Vitamin C Against Genotoxic Damage Frommentioning

confidence: 99%

The Role of Vitamin C in the Protection and Modulation of Genotoxic Damage Induced by Metals Associated with Oxidative Stress

2017

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This chapter reviews the efects of vitamin C on metal-induced genotoxicity. By focusing on cuting-edge studies, including our own results in experiments with vanadium(V) and chromium(VI), the suggestion that vitamin C can be used efectively to protect against or reduce the genotoxic efects induced by metal exposure by suppressing oxidative stress is particularly explored. After explaining the chemical mechanisms involved in oxidative stress associated with heavy metals, this chapter discusses the various proposals regarding the physiological processes of vitamin C at the molecular level, its relationship with oxidative stress, levels of 8-hydroxydeoxyguanosine 7, and apoptosis, and its role in the protection and modulation of DNA damage, as well as how they it with our own results that showed an increase in apoptosis and 8-OH-dG when vitamin C was administered in addition to the metallic compounds. The relevant gaps in our understanding of the role of vitamin C with regard to these issues are highlighted, as well as the key importance of its clinical use, and ultimately, human health.

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“…[9,17,18] Additionally, oxidovanadium (also known as "oxovanadium") complexes exhibited apoptosisinducing ability together with increased cytotoxicity relative to those of the free ligands, emphasizing the importance of the metal core. [16,19] For example, complexation of flavonoid ligands with oxidovanadium cores improved the cytotoxic activity relative to that of the starting materials, mainly due to generation of reactive oxygen species.…”

Section: Introductionmentioning

confidence: 99%

“…The biological role of vanadium includes influencing diverse signaling pathways, depending on the oxidation state of the metal, the structure of the complex, and the nature of its ligands. [8][9][10] Clinical trials of several vanadium compounds found no significant side effects, and although mild toxicity was revealed at high doses, it was reversible. [11] These characteristics led to increased interest in vanadium compounds as therapeutic agents for diverse diseases, including diabetes mellitus, hypertension, hyperlipidemia, and cancer.…”

Section: Introductionmentioning

confidence: 99%

“…[11] These characteristics led to increased interest in vanadium compounds as therapeutic agents for diverse diseases, including diabetes mellitus, hypertension, hyperlipidemia, and cancer. [9,12] Regarding the latter, vanadium complexes have demonstrated encouraging cytotoxic activity against a broad range of human cancer cells lines, some of which are cisplatin-resistant. [13][14][15][16] For instance, vanadocene di-structures of the complexes featured octahedral geometry for both.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic Vanadium Complexes of Branched [ONNO]‐Type Diamine Bis(phenolato) Ligands

et al. 2017

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Vanadium complexes are attractive potential alternatives to platinum-based anticancer drugs. Two vanadium(V) complexes, based on a common chelating tetradentate diaminobis(phenolato) ligand featuring a branched connectivity but differing in their labile ligands, were synthesized and characterized. Whereas the isopropoxido complex was obtained as a mixture of cis and trans isomers with regard to the orientation of the labile group vs. the amine sidearm, the salicylato-containing complex was obtained as a single trans isomer. X-ray

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The chemistry and biology of vanadium compounds in cancer therapeutics

Cited by 227 publications

References 126 publications

A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand. A combined experimental and theoretical study and cytotoxity against K562 cells

A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand. A combined experimental and theoretical study and cytotoxity against K562 cells

The Role of Vitamin C in the Protection and Modulation of Genotoxic Damage Induced by Metals Associated with Oxidative Stress

Cytotoxic Vanadium Complexes of Branched [ONNO]‐Type Diamine Bis(phenolato) Ligands

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