The chemistry and biological activities of Peperomia pellucida (Piperaceae): A critical review

Alves, Nayara Sabrina F.; Setzer, William N.; Silva, Joyce Kelly R. da

doi:10.1016/j.jep.2018.12.021

Cited by 37 publications

(31 citation statements)

References 86 publications

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“…Arora, Kumar, Agarwal, Reeta, and Gupta (2018) have suggested the synergistic interaction between triterpenes and flavonoids in the methanol extract of C. asiatica could enhance enzymatic antioxidant activity in rat. A similar observation was reported on the anti‐radical activities of superoxide dismutase and catalase in diabetic rat fed with P. pellucida (Alves et al., 2019). This has provided further evidence to support C. asiatica and P. pellucida as strong potential candidates for therapeutic drug development (Dewi & Maryani, 2015; Kartika, Insanu, Safitri, Putri, & Adnyana, 2016).…”

Section: Resultssupporting

confidence: 85%

“…This finding may suggest the different types of phenolic compounds presented in M. acuminata and P. tetragonolobus when compared to those found in P. pellucida and C. asiatica . For instance, kaempferol and quercetin were identified as the major phenolic compounds in C. asiatica ethyl acetate extract (Dewi & Maryani, 2015), while P. pellucida water extract contained diterpenes, alkaloids, tannins, steroids, saponins, and flavonoids such as flavone glycosides (Alves et al., 2019). The n ‐hexane extract of M. acuminata flower mainly consisted of condensed tannin, saponins, flavonoids, and carbohydrate complexes (Mathew & Negi, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…The major phytochemicals found in P. pellucida consists of alkaloids, flavonoids, sterols, tannins, saponins, terpenoids, phenols, carotenoids, and quinones with anti‐microbial, antihypercholesterolemia, immunomodulatory, and analgesic properties (Mun'im, Nurpriantia, Setyaningsih, & Syahdi, 2017). This herbaceous plant is mainly used to treat malaria, eye disease, gout, gastrointestinal, and renal disorders (Alves, Setzer, & da Silva, 2019). P. tetragonolobus is an underutilized legume vegetable popular in the supporting human immune system and bone health through the protein, vitamins, and secondary metabolites including phenolic and flavonoids (Singh et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

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The antioxidant index and chemometric analysis of tannin, flavonoid, and total phenolic extracted from medicinal plant foods with the solvents of different polarities

Samsuri

Yong

2020

J Food Process Preserv

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This study aimed to evaluate the effect of four solvents (water, methanol, ethyl acetate, and n‐hexane) on the extraction of total phenolic content (TPC), tannin, flavonoid, ferric reducing power (FRAP), and radical scavenging activity from Centella asiatica, Musa acuminata, Peperomia pellucida, and Psophocarpus tetragonolobus. The extraction of TPC, tannin, flavonoid, and antioxidant activity varied significantly according to solvent polarity and plant species. The strong linear correlation found between solvent polarity index and TPC, tannin, FRAP as well as radical scavenging activity indicated solvents with increasing polarity favored the extraction of phenolic antioxidants. Plant species and extraction solvents contributed to 51.7% and 21.8% of total activity variation, respectively. C. asiatica, M. acuminata flower, and P. pellucida were best extracted with 80°C distilled water for a short duration, while methanol was preferred for P. tetragonolobus. The antioxidant index could be a potential ranking tool to identify the ideal extraction solvent for medicinal plants. Practical applications Considering the high commercial and health‐oriented values of natural phenolic antioxidants such as tannin and flavonoid, efficient extraction of these phytochemicals from different plant sources remains a challenging task due to their varying physicochemical characteristics and solubility. This study has addressed that the choice of solvents and types of plant species are critical extraction parameters for natural plant products. Comparison of tannin and flavonoid content among the different solvent extracts could reveal the ideal solvent which maximizes the extraction of phenolic antioxidants from different medicinal plants. The finding in this study may inspire nutraceutical, pharmaceutical, and cosmetic industries to re‐evaluate their procedure in selecting the optimal extraction solvent and condition for different plant materials. The proposed antioxidant index in this study could serve as a potential tool to rank extraction solvents based on the antioxidant values extracted from different medicinal plants.

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Section: Resultssupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The antioxidant index and chemometric analysis of tannin, flavonoid, and total phenolic extracted from medicinal plant foods with the solvents of different polarities

Samsuri

Yong

2020

J Food Process Preserv

View full text Add to dashboard Cite

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“…Traditionally, PP has been used in the treatment of a wide variety of diseases. Local communities of the pantropical have been using PP to treat several types of pain [4]. The areal parts of the plant have been described to treat various kidney diseases and decoction of the entire plant is used against poisonous animal bites by the Miskitu indigenous group of eastern Nicaragua [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Local communities of the pantropical have been using PP to treat several types of pain [4]. The areal parts of the plant have been described to treat various kidney diseases and decoction of the entire plant is used against poisonous animal bites by the Miskitu indigenous group of eastern Nicaragua [4,5]. In Brazil, local communities have used PP in the treatment of abscesses, furuncles, inflammation in general, and hypertension [4].…”

Section: Introductionmentioning

confidence: 99%

Pellucidin A promotes antinociceptive activity by peripheral mechanisms inhibiting COX-2 and NOS: In vivo and in silico study

et al. 2020

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Peperomia pellucida (PP) belongs to the Peperomia genus, which has a pantropic distribution. PP is used to treat a wide range of symptoms and diseases, such as pain, inflammation, and hypertension. Intriguingly, PP extract is used by different tropical countries for its anti-inflammatory and antinociceptive effects. In fact, these outcomes have been shown in animal models, though the exact bioactive products of PP that exert such results are yet to be discovered. To determine and elucidate the mechanism of action of one of these compounds, we evaluated the antinociceptive effect of the novel dimeric ArC2 compound, Pellucidin A by using in vivo and in silico models. Animals were then subjected to chemical, biphasic and thermal models of pain. Pellucidin A induced an antinociceptive effect against chemical-induced pain in mice, demonstrated by the decrease of the number of writhes, reaching a reduction of 43% and 65% in animals treated with 1 and 5 mg/kg of Pellucidin A, respectively. In the biphasic response (central and peripheral), animals treated with Pellucidin A showed a significant reduction of the licking time exclusively during the second phase (inflammatory phase). In the hot-plate test, Pellucidin A did not have any impact on the latency time of the treated animals. Moreover, in vivo and in silico results show that Pellucidin A's mechanism of action in the inflammatory pain occurs most likely through interaction with the nitric oxide (NO) pathway. Our results demonstrate that the antinociceptive activities of Pellucidin A operate under mechanism(s) of peripheral action, involving inflammatory mediators. This work provides insightful novel evidence of the biological properties of

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Peperomia pellucida (L.) Kunth suppresses glycation‐induced inflammatory response in human retinal pigment epithelial cell line ARPE‐19 via JAK‐STAT3 signaling

Ho,

Yong,

Lim

et al. 2024

Archiv der Pharmazie

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The formation of advanced glycation end product (AGE) is a risk factor for diabetic retinopathy. Since the current treatment for diabetic retinopathy is accompanied by side effects, preliminary findings have suggested Peperomia pellucida (L.) Kunth as a potential alternative therapeutic option for diabetic retinopathy. This study aimed to elucidate the anti‐inflammatory mechanism of P. pellucida in the AGE‐stimulated human retinal pigment epithelial cell line ARPE‐19. Phytochemical analysis revealed phenylpronanoids, terpenes, and fatty acids in P. pellucida. Through in vitro cell viability assay, the P. pellucida methanolic extract (IC50 = 8.70 mg/mL) and ethyl acetate fraction (IC50 = 7.34 mg/mL) were considered as non toxic for ARPE‐19. AGE induced an inflammatory response in ARPE‐19 by upregulating the gene (2.4–5.8‐fold) and protein (1.4–2.3‐fold) expression of signal transducer and activator of transcription 3 (STAT3), interleukin‐8 (IL‐8), monocyte chemoattractant protein‐1, matrix metalloproteinase 2, and vascular endothelial growth factor. At 1.5 mg/mL, P. pellucida methanolic extract suppressed IL‐8 expression (p < 0.05), implying its anti‐inflammatory action at the early inflammatory stage through the Janus kinase (JAK)‐STAT3 pathway. The methanolic extract also restored the ARPE‐19 viability under AGE‐induced inflammatory stress. The downregulation of inflammatory biomarkers along the JAK‐STAT3 pathway suggested P. pellucida as a promising anti‐inflammatory source for diabetic retinopathy.

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The chemistry and biological activities of Peperomia pellucida (Piperaceae): A critical review

Cited by 37 publications

References 86 publications

The antioxidant index and chemometric analysis of tannin, flavonoid, and total phenolic extracted from medicinal plant foods with the solvents of different polarities

The antioxidant index and chemometric analysis of tannin, flavonoid, and total phenolic extracted from medicinal plant foods with the solvents of different polarities

Pellucidin A promotes antinociceptive activity by peripheral mechanisms inhibiting COX-2 and NOS: In vivo and in silico study

Peperomia pellucida (L.) Kunth suppresses glycation‐induced inflammatory response in human retinal pigment epithelial cell line ARPE‐19 via JAK‐STAT3 signaling

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