The chemical metamorphosis of taxane diterpenes by synthetic design

Abstract

The construction of molecular carbon frameworks stands as the fundamental objective of organic chemistry. The carbon skeleton of each organic molecule serves as the foundation for its three-dimensional structure, playing a pivotal role in determining its physical and biological properties. Within the realm of synthesis, the ability to access complex molecules while prioritizing skeletal diversification serves as a crucial factor in advancing the frontiers of efficient synthetic design. In line with this pursuit, our team has developed a versatile synthetic strategy. This strategy not only enables structural diversification but also facilitates the metamorphosis of complex molecular frameworks, such as the taxane diterpenes, into one another. Through our innovative approach, we have unlocked the transformative power to interconvert and manipulate these intricate structures. The implications of our findings extend beyond conventional synthetic chemistry, presenting exciting opportunities for creating a diverse array of molecules with unparalleled flexibility. This achievement opens new avenues for exploration and holds promise for future advancements and applications in this dynamic scientific field.