The Chemical Formulation of Gene Structure and Gene Action

Gulick, Addison

doi:10.1002/9780470122495.ch1

Cited by 5 publications

(2 citation statements)

References 176 publications

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“…should result in a specialization of genes, when each then fulfills only one function which is strictly limited and important for the life of the organism" (cited in Taylor and Raes 2004, 617). The first ideas regarding the molecular nature of genes emerged in the 1940s, when the "Possible Significance of Duplication in Evolution," which is the title of a paper by Stephens (1951), was revisited (Beadle 1945;Gulick 1944). Stephens concluded that the duplication-divergence mechanism is a very attractive possible mechanism, but that no fully compelling evidence for it existed at that time.…”

Section: Evolution By Gene Duplicationmentioning

confidence: 97%

The Discovery of De Novo Gene Evolution

Tautz¹

2014

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Genes can evolve via duplication and divergence mechanisms, but also de novo out of non-coding intergenic sequences. This latter mechanism has only recently become fully appreciated, while the former mechanism was an almost exclusive dogma for quite some time. This essay explores the history of this development: why a view developed, with the alternative hardly being explored. Because of the prevailing view, an important aspect of the nature of genes and their evolutionary origin escaped our attention. Evidence is now rapidly accumulating that de novo evolution isa very active mechanism for generating novelty in the genome, and this will require anew look at how genes arise and become functional.

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Section: Evolution By Gene Duplicationmentioning

confidence: 97%

The Discovery of De Novo Gene Evolution

Tautz¹

2014

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“…Goldschmidt (41), who focused on the role of chromosome repatterning in macroevolution, did not believe that human and amoeba were connected by mutations of the same genes. In 1944, Gulick (46) argued, "The whole history of many-celled organisms must undoubtedly have called for frequent increases in gene count as the organism advanced toward great complexity. "…”

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confidence: 99%

Duplication and Divergence: The Evolution of New Genes and Old Ideas

2004

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Over 35 years ago, Susumu Ohno stated that gene duplication was the single most important factor in evolution. He reiterated this point a few years later in proposing that without duplicated genes the creation of metazoans, vertebrates, and mammals from unicellular organisms would have been impossible. Such big leaps in evolution, he argued, required the creation of new gene loci with previously nonexistent functions. Bold statements such as these, combined with his proposal that at least one whole-genome duplication event facilitated the evolution of vertebrates, have made Ohno an icon in the literature on genome evolution. However, discussion on the occurrence and consequences of gene and genome duplication events has a much longer, and often neglected, history. Here we review literature dealing with the occurrence and consequences of gene duplication, beginning in 1911. We document conceptual and technological advances in gene duplication research from this early research in comparative cytology up to recent research on whole genomes, "transcriptomes," and "interactomes."

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A Study of Pleiotropic Genes in Maize

Tulpule

1954

American J of Botany

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The Chemical Formulation of Gene Structure and Gene Action

Cited by 5 publications

References 176 publications

The Discovery of De Novo Gene Evolution

The Discovery of De Novo Gene Evolution

Duplication and Divergence: The Evolution of New Genes and Old Ideas

A Study of Pleiotropic Genes in Maize

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