The Chemical Estimation of Catecholamines and their Metabolites in Body Fluids and Tissue Extracts

Weil‐Malherbe, H.

doi:10.1002/9780470110409.ch5

Cited by 69 publications

(9 citation statements)

References 85 publications

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“…was collect ed every day and compounded with HC1 and frozen at -40 "C until determination. NE and E was determined according to Weil-Malherbe (1971).…”

Section: Patients Controls and Methodsmentioning

confidence: 99%

MHPG Excretion during Sleep Deprivation in Endogenous Depression

Matussek¹,

Römisch²,

Ackenheil³

1977

Neuropsychobiology

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MHPG excretion of 14 endogenously depressive patients and 5 healthy controls was investigated before, during and after a night of sleep deprivation (SD). Patients having a minimum improvement of 40 % in the Cronholm-Ottoson rating scale had shown a significantly higher MHPG excretion in the night before SD (p < 0.02) as compared to the non-improved group. The MHPG excretion of the night before SD shows a significant negative correlation, both with the depression score according to Cronholm-Ottoson (p < 0.05) and with the self-rating score according to von Zerssen (p < 0.005), on the day after SD. No correlation was found between the motor activity measured by pedometer and MHPG excretion. The results are discussed in connection with values found in controls.

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“…was collect ed every day and compounded with HC1 and frozen at -40 "C until determination. NE and E was determined according to Weil-Malherbe (1971).…”

Section: Patients Controls and Methodsmentioning

confidence: 99%

MHPG Excretion during Sleep Deprivation in Endogenous Depression

Matussek¹,

Römisch²,

Ackenheil³

1977

Neuropsychobiology

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“…Red blood cells (RBCs) were separated within 1 h of collection of blood for the estimation of membrane Na þ , K þ -ATPase. Serotonin was estimated by the method of Curzon et al and catecholamines by the method of Well-Malherbe et al [14,15]. Plas-ma=serum was used for the estimation of the other parameters.…”

Section: Methodsmentioning

confidence: 99%

The Isoprenoid Pathway and the Pathogenesis of Reye's Syndrome

Kurup¹,

Kurup²

2003

Pediatric Pathology & Molecular Medicine

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u The isoprenoid pathway produces three key metabolites: endogenous digoxin (regulator of neurotransmitter uptake), dolichol, and ubiquinone (free radical scavenger). Since a mitochondrial dysfunction has been described in Reye' s syndrome, it was considered pertinent to assess the pathway in this disease. Since endogenous digoxin can regulate neurotransmitter transport, the pathway was also assessed in patients with right hemispheric, left hemispheric, and bihemispheric dominance to ¢nd out the role of hemispheric dominance in its pathogenesis. The plasma=serum activity of hydroxy methyl glutaryl (HMG) coenzyme A (CoA) reductase, magnesium, digoxin, dolichol, ubiquinone, tryptophan=tyrosine catabolic patterns, and free radical and lipid levels, as well as RBC Na þ , K þ -ATPase activity, were measured in the groups mentioned. Results: In the patient group as well as in individuals with right hemispheric dominance similar patterns were obtained. There was elevated digoxin and dolichol levels with low levels of ubiquinone in patients with Reye' s syndrome as well as in those with right hemispheric dominance.The serum magnesium and RBC Na þ , K þ -ATPase activity were reduced. There was also an increase in tryptophan catabolites and a reduction in tyrosine catabolites as well as increased free radical levels. Reye' s syndrome is associated with an upregulated isoprenoid pathway, elevated hypothalamic digoxin secretion, and right hemispheric chemical dominance.

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“…40 filter paper into 50 m] glass stoppered tubes containing 0.35 g A1208 which was prepared according to Weil-Malherbe (1971). Striata of one rat and pooled forebrain cortices of 4 rats were homogenized in 10 ml 0.4 N perchloric acid containing 0.5 ~ EDTA and 0.05 ~ Na~S~Os.…”

Section: Assays and Statisticsmentioning

confidence: 99%

Effect of morphine on dopaminergic neurons in the rat basal forebrain and striatum

Moleman

Bruitivels

1979

J. Neural Transmission

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Administration of morphine (20 mg/kg i.p.) resulted in an increase in the rate of dopamine (DA) loss by ca. 40% in the forebrain cortex of rats, when the drug was administered 30 min after treatment with the synthesis inhibitor alpha-methyl-para-tyrosine methylester (alpha-MpT). This effect was specific as it was antagonized by naloxone. In the same rats the rate of DA loss in the striatum was unaltered. It was shown that this differential effect was not due to a delayed inhibition of DA synthesis in the forebrain cortex when compared with the striatum. When morphine, on the other hand, was administered before inhibition of DA biosynthesis (30 min before alpha-MpT) an increase in the rate of DA loss was also observed in the striatum and a more marked increase was seen in the forebrain cortex. Sub-dissection of the forebrain cortex showed that most of the DA (80%) was present in basal parts of the forebrain and not in the frontal or cingulate cortex. The results suggest, therefore, that morphine administration results in DA release in basal parts of the forebrain, but not in the striatum.

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The Chemical Estimation of Catecholamines and their Metabolites in Body Fluids and Tissue Extracts

Cited by 69 publications

References 85 publications

MHPG Excretion during Sleep Deprivation in Endogenous Depression

MHPG Excretion during Sleep Deprivation in Endogenous Depression

The Isoprenoid Pathway and the Pathogenesis of Reye's Syndrome

Effect of morphine on dopaminergic neurons in the rat basal forebrain and striatum

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