The Chemical Constituents and the Cytotoxicity, Antioxidant and Antibacterial Activities of the Essential Oil of<i>Graptophyllum pictum</i>(L.) Griff.

Jiangseubchatveera, Nadechanok; Liawruangrath, Boonsom; Liawruangrath, Saisunee; Teerawutgulrag, Aphiwat; Santiarworn, Dammrong; Korth, Jurgen; Pyne, Stephen G.

doi:10.1080/0972060x.2014.935036

Cited by 20 publications

(26 citation statements)

References 11 publications

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“…Although several ethnobotanical reports have emphasized the pharmacological importance of this species for conditions that appear to be associated with microbial infections, there is very limited literature concerned with the identification of the antimicrobial compounds from this plant. However, a few reports on the in vitro antimicrobial activity of plants have been published [ 14 , 15 ]. The objective of this investigation was to evaluate the antimicrobial activities of flavonoid glycosides from G. grandulosum , as well as to determine their mechanism of action using lysis, leakage, and osmotic stress assays.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activities of flavonoid glycosides from Graptophyllum grandulosum and their mechanism of antibacterial action

Tagousop

Tamokou

Ekom

et al. 2018

BMC Complement Altern Med

119

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BackgroundThe search for new antimicrobials should take into account drug resistance phenomenon. Medicinal plants are known as sources of potent antimicrobial compounds including flavonoids. The objective of this investigation was to evaluate the antimicrobial activities of flavonoid glycosides from Graptophyllum grandulosum, as well as to determine their mechanism of antibacterial action using lysis, leakage and osmotic stress assays.MethodsThe plant extracts were prepared by maceration in organic solvents. Column chromatography of the n-butanol extract followed by purification of different fractions led to the isolation of five flavonoid glycosides. The antimicrobial activities of extracts/compounds were evaluated using the broth microdilution method. The bacteriolytic activity was evaluated using the time-kill kinetic method. The effect of extracts on the red blood cells and bacterial cell membrane was determined by spectrophotometric methods.ResultsChrysoeriol-7-O-β-D-xyloside (1), luteolin-7-O-β-D-apiofuranosyl-(1 → 2)-β-D-xylopyranoside (2), chrysoeriol-7-O-β-D-apiofuranosyl-(1 → 2)-β-D-xylopyranoside (3), chrysoeriol-7-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-(4"-hydrogeno sulfate) glucopyranoside (4) and isorhamnetin-3-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (5) were isolated from G. grandulosum and showed different degrees of antimicrobial activities. Their antibacterial activities against multi-drug-resistant Vibrio cholerae strains were in some cases equal to, or higher than those of ciprofloxacin used as reference antibiotic. The antibacterial activities of flavonoid glycosides and chloramphenicol increased under osmotic stress (5% NaCl) whereas that of vancomycin decreased under this condition. V. cholerae suspension treated with flavonoid glycosides, showed a significant increase in the optical density at 260 nm, suggesting that nucleic acids were lost through a damaged cytoplasmic membrane. A decrease in the optical density of V. cholerae NB2 suspension treated with the isolated compounds was observed, indicating the lysis of bacterial cells. The tested samples were non-toxic to normal cells highlighting their good selectivity index.ConclusionsThe results of the present study indicate that the purified flavonoids from G. glandulosum possess antimicrobial activities. Their mode of antibacterial activity is due to cell lysis and disruption of the cytoplasmic membrane upon membrane permeability.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial activities of flavonoid glycosides from Graptophyllum grandulosum and their mechanism of antibacterial action

Tagousop

Tamokou

Ekom

et al. 2018

BMC Complement Altern Med

119

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“…in Asian folk medicine as anthelmintic and syphilis infection. A study by (Jiangseubchatveera et al, 2015) demonstrated that G. pictum inhibited S. aureus and E. coli with MIC values of 11.75 and 35.25 µg/disc (Jiangseubchatveera et al, 2015). The ethanol extract of P. cattleianum showed higher antimicrobial activity against Gram-positive and harmful bacteria tested when compared to the aqueous extract (Scur et al, 2016).…”

Section: Resultsmentioning

confidence: 98%

Antibacterial activity of several Indonesian plant extracts and combination of antibiotics with Syzygium malaccense extract as the most active substance

Yuniarni¹,

Sukandar²,

Fidrianny³

2020

ijrps

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Natural products have an important role in the development of drugs, especially as an antibacterial. Some plant extracts in Indonesia such as Syzygium (Myrtaceae) and Graptophyllum (Acanthaceae) have been used empirically for the treatment of non-infectious diseases, and are also for management infections such as throat, mouth and vaginal infections, dysentery and diarrhea. The objectives of this study are to investigate antibacterial activity of 11 extracts from ten plants which were used in traditional medicine in Indonesia to treat infection disease and to evaluate interaction between potential antibacterial extract and antibiotics. Antibacterial activity and combination extract with antibiotics were evaluated using agar diffusion method on Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. Among the ten plants, Syzygium malaccense leaves extract, and Nephelium lappaceum peel and leaves extracts showed significant antibacterial activity. They have antibacterial activity against Gram positive and Gram negative. S. malaccense extract had better antibacterial activity against P. aeruginosa compared to the other tested bacteria and provided better activity compared to N. lappaceum leaves extract. Phytochemical screening showed that S. malaccense leaves extract contained flavonoid, tannin, quinone, phenol and triterpenoid/steroid. The combination of S. malaccense extract with antibiotics showed that the usage of S. malaccense extract together with ciprofloxacin gave antagonistic result, so the usage of S. malaccense extract together with ciprofloxacin needs caution because it can reduce the effect of ciprofloxacin.

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“…(Hossain et al, 2014;Parveen et al, 2019;Nugroho et al, 2014) (Khoo et al, 2018;Kamarudina et al, 2017;Tsai et al, 2016) ALP assay result shows that nbutanol and water fractions of G. pictum has signi icant stimulating activity of ALP (112% and 122% respectively) against MC3T3-E1. (Jiangseubchatveera et al, 2017(Jiangseubchatveera et al, , 2015Widyowati, 2011) chloride (CCL 4 ) -induced hepatic microsomal lipid peroxides but not by the andrographolide phyto compound. This indicates hepatoprotective properties of the plant (Hossain et al, 2014) .Research of (Parveen et al, 2019) reported that hot aqueous and methanol aerial extract of the plant show the remarkable decreases in the Human Immunode iciency Viruses (HIV) antigen-positive H9 cell percentage this proof that plant have an anti-viral effect.…”

Section: A Paniculatamentioning

confidence: 99%

“…For cytotoxic activity of the plant, they took 3 cancerous human cell lines, KB (epidermoid carcinoma), MCF-7 (breast adenocarcinoma) and NCI-H187 (small cell lung carcinoma) and treated with different solvent fractions, with the use of Resazurin microtitre assay (REMA) they determined that 3 fractions (hexane, ethyl acetate and aqueous ) has the highest capacity of cytotoxic against MCF-7 growth cell lines (with the IC 50 values of 38.66, 26.01 and 20.41µg/ml respectively) and there is no cytotoxic action of fractions against Vero cells is seen. In-vitro, disc diffusion assay, examined by (Jiangseubchatveera et al, 2015) to determine antibacterial properties of the plant, reveals that the oil extract of leaves has a strong antibacterial activity against Escherichia coli and Staphylococcus aureus with MIC values (11.75 and 35.25µg/disc) respectively. ALP marker of osteoblast differentiation is evaluated by (Widyowati, 2011), by using 70% Ethanol-water extract with sequential fractions (n-butanol, ethyl acetate and water solvent) against MC3T3-E1 osteoblast cell.…”

Section: G Pictummentioning

confidence: 99%

Review on biological activities in medicinal plants of acanthaceae family

Manjula¹,

Sankar²

2021

ijrps

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Acanthaceae is popularly known as acanthus family which belong to mint order – lamiales. They are distributed from tropics to a temperate region such as India, Malaysia, Brunei, Indonesia, Brazil, Central America and Africa. Most members of this family are therapeutically important since they are in the up to date usage by ethnic communities. Andrographis paniculata, Clinacanthus nutans, Graptophyllum pictum, Hemigraphis alternata, Justicia gendarussa and Strobilanthes Crispus are some of the medicinal plants of Acanthaceae family. These plants are recognized for their biopharmaceutical potential usage in traditional medicine. These plants have a plethora of phytochemical compounds such as flavonoids, phenolic compounds, glycosides, terpenoids, benzenoids, quinine, triterpenoids and naphthoquinone present in various parts of the plant that plays a vital role in drug industries. The pharmacological properties of these plants such as anti-bacterial, anti-diabetic, anti-cancer, anti-oxidant, anti-inflammatory, anti-arthritis, hepatoprotective, anti-viral and anti-hypertensive are in general practice as an alternative and complementary medicine in both ethnobotanical and pharmacological fields. This article encompasses not only the comprehensive survey based on the electronic resources, scientific journals but also the books that summarize the botanical, phytochemical properties of these plants and also accentuate their significant role in both ethnobotanical and pharmacological fields. It is felt that this article would provide more insight into the health benefits of some plants of the Acanthaceae family.

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The Chemical Constituents and the Cytotoxicity, Antioxidant and Antibacterial Activities of the Essential Oil ofGraptophyllum pictum(L.) Griff.

Cited by 20 publications

References 11 publications

Antimicrobial activities of flavonoid glycosides from Graptophyllum grandulosum and their mechanism of antibacterial action

Antimicrobial activities of flavonoid glycosides from Graptophyllum grandulosum and their mechanism of antibacterial action

Antibacterial activity of several Indonesian plant extracts and combination of antibiotics with Syzygium malaccense extract as the most active substance

Review on biological activities in medicinal plants of acanthaceae family

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