The chemical constituents and diverse pharmacological importance of Tinospora cordifolia

Abstract

Tinospora cordifolia is a popular medicinal plant which is used in several traditional medicines to cure various diseases. The common names are Amrita and Guduchi and belong to the family of Menispermaceae. It is considered an essential herbal plant of Indian system of medicine (ISM) and has been used in the treatment of fever, urinary problem, dysentery, skin diseases leprosy, diabetes, and many more diseases. The plant reported containing chemical compound including Alkaloids, Terpenoids, Lignans, Steroids and others that establish the phytochemistry and pharmacological activity of Tinospora cordifolia. The present review highlights the pharmacological importance viz antioxidant activity, antimicrobial activity, antibacterial activity, antifungal activity, anti-diabetic activity, antistress activity, hypolipidaemic effect, hepatic disorder, anticancer anti HIV potential, antiosteoporotic effects, antitoxic effects, wound healing, anticomplementary activity, and immunomodulating activity, systemic infection and Parkinson's disease.

Traditional herbal healing practices for the treatment of Malaria and associated symptoms by Miju-Mishmi tribe of Lohit district, Arunachal Pradesh, Northeast India

“…H. pubescens along with antidiabetic activity [54]. In T. cordifolia, pharmacological activities of phenolic compounds have shown antifungal, anticancer, antioxidant, and antimicrobial properties [55]. It is considered that because of the presence of these essential secondary metabolites, most of the plants are widely used in the Indian system of medicine (ISM) since long and hence also popularity re ex among the ethnic tribe of different corners of India.…”

Computationally approached inhibition potential of Tinospora Cordifolia towards COVID-19 targets

“…The same is also reported to induce immunomodulatory effect [28][29][30] in human immuno-deficiency virus positive patients. [31] Tinospora cordifolia is known to exhibit a broad spectrum of therapeutic activities [32].…”

Efficacy of natural compounds from Tinospora cordifolia against SARS-CoV-2 protease, surface glycoprotein and RNA polymerase.

“…[11][12][13][14][15] Besides this, the plant extract is also shown to have wound healing, and immunomodulating properties. [15,16] The leaf extract of TC is reported to have antimicrobial activity against grampositive and gram-negative bacteria, clinically relevant fungal infections and malarial parasites. [13,15,16] The antimicrobial properties of TC extracts is attributed to its phytoconstituents such as furanolactone, tinosporon, jateorine and columbin.…”

“…[15,16] The leaf extract of TC is reported to have antimicrobial activity against grampositive and gram-negative bacteria, clinically relevant fungal infections and malarial parasites. [13,15,16] The antimicrobial properties of TC extracts is attributed to its phytoconstituents such as furanolactone, tinosporon, jateorine and columbin. [15][16][17] The silver nanoparticles from Tinospora cordifolia were reported to be effective against chikungunya virus.…”

“…[13,15,16] The antimicrobial properties of TC extracts is attributed to its phytoconstituents such as furanolactone, tinosporon, jateorine and columbin. [15][16][17] The silver nanoparticles from Tinospora cordifolia were reported to be effective against chikungunya virus. [17] Phytochemicals from TC are also reported be effective inhibitors of H1N1 viral proteins.…”