The chemical constituents and biological activity of some sponges in Northern Vietnam: A review

Abstract

Chemical composition and biological activity of sponges have been studied by the authors since 2006. So far, the authors have studied about 30 species of sponges, mainly collected cross in the sea of Northern Vietnam. Over 250 compounds have been isolated and elucidated their chemical structures. Among them, there are more than 50 compounds with new chemical structures. In addition to NMR and HRMS spectra, many compounds with an unequal chemical structure are also determined by Circular Dichroism spectrometry. Some isolated compounds exhibited outstanding potential for cancer cytotoxicity and anti-inflammatory effects. Keywords. Sponge chemical constituent, Porifera, Vietnam marine natural product. composition and in reserves. there are seabirds. However, researches on chemistry and compounds Vietnam Journal of Chemistry Phan Van Kiem et al.

Xestospongia muta Fraction-7 and Linoleic Acid: Effects on SR-BI Gene Expression and HDL Cholesterol Uptake

“…According to the Natural Product Report, about 300 novel compounds were determined from sponges in the decade 2001-2010 and estimated in the decade 2011-2020 on average each year. In addition, novel compounds from sponges have increased even more [14][15][16]. The chemical structure of the compounds from sponges is also diverse, such as fatty acids, glycolipids, macrolide, peptides, peroxide, polyketide, quinone, steroids, terpenoids, and alkaloids.…”

“…The chemical structure of the compounds from sponges is also diverse, such as fatty acids, glycolipids, macrolide, peptides, peroxide, polyketide, quinone, steroids, terpenoids, and alkaloids. Their fatty acids and ester derivatives exhibit anti-inflammatory activity, quinone derivatives are characterized by anti-malarial and anti-HIV properties, polyketides, polybrominated peptides, and macrolactam have anti-microbial properties, and dihydropyridine alkaloids have a protective effect on nerve cells [14,17]. Xestospongia muta (Schmidt, 1870; family Petrosiidae), commonly called the giant barrel sponge, is the largest species of sponge found growing in the Caribbean coral reef.…”

Diversity of prokaryotic communities associated with sponges in Vietnam and their secondary metabolite biosynthetic potential

“…Along with studies on sponge taxonomy, investigations of bioactive compounds from marine sponges in Vietnam have received considerable attention since 2006. So far, more than 250 natural products have been isolated and their chemical structures elucidated from about 30 sponge species, mainly collected in the sea of Northern Vietnam, including more than 50 new compounds (Kiem et al, 2019). Vietnamese sponge-derived compounds have diverse structures and include various classes such as steroids, sesquiterpenes, triterpenes, alkaloids, and other compounds.…”

“…Vietnamese sponge-derived compounds have diverse structures and include various classes such as steroids, sesquiterpenes, triterpenes, alkaloids, and other compounds. These compounds have been targeted for evaluation of their anticancer and anti-inflammatory activities, many of which exhibited outstanding anticancer and antiinflammatory effects (Kiem et al, 2019), whereas their pharmacological properties e.g., antibacterial, antifungal, antivirus, etc. have not been studied yet.…”

“…Taxonomic investigations on several shallow sea areas of Vietnam, i.e., Nha Trang Bay, Con Co island, limestone island, and coastal regions of North-Central Vietnam, have revealed a high diversity of marine sponges, with more than 229 identified sponge species belonging to 124 genera, 65 families, 18 orders, and 4 classes (Thai, 2013;Calcinai et al, 2020;Huong et al, 2020;Do Cong, 2022). Subsequent studies on Vietnamese sponge-derived natural products have led to the isolation of more than 250 natural products from about 30 sponge species, including more than 50 new compounds (Kiem et al, 2019), many of which exhibited outstanding anticancer and antiinflammatory effects (Kiem et al, 2019).…”